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(Also known as Karvezide,Coaprovel)
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Chemical Name Irbesartan (ir-be-SAR-tan)/HCTZ (hye-droe-klor-oh-THYE-a-zide)
AVALIDE is a combination of irbesartan and hydrochlorothiazide that is used to treat high blood pressure. Irbesartan is in a class of medications called angiotensin II antagonists. It works by blocking the action of certain natural chemicals that tighten the blood vessels, making blood flow more smoothly. Hydrochlorothiazide is in a class of medications called diuretics (water pills). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
Take AVALIDE as exactly as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results. Take this medication with a full glass (8 ounces) of water.
It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medication even if you feel fine. High blood pressure often has no symptoms.
The following patients should not use this medication:
- those who are allergic to irbesartan or hydrochlorothiazide
- those who are unable to urinate
- patients who are pregnant or planning on becoming pregnant
In rare cases, AVALIDE can cause a condition that result in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine. Also, contact your doctor immediately if you experience signs of an allergic reaction (hives, difficulty breathing and/or swelling of your face, lips, tongue, or throat).
Additional serious side effects may include:
- feeling light-headed or faintness
- chest pain
- shortness of breath, even with mild exertion
- swelling, rapid weight gain
- urinating more or less than usual, or not at all
- dry mouth, increased thirst
- drowsiness, restless feeling
- rapid heart rate
- seizure (convulsions)
- stomach pain, heartburn
- muscle pain
- dizziness, drowsiness
- runny or stuffy nose, sore throat
- dry cough
Product Code: 1359
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.