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Tretinoin cream is used to treat photodamaged skin (skin that has been damaged by the sun). Tretinoin is a natural form of vitamin A that works by increasing the thickness and collagen level of the skin and by exfoliating the skin's outer layer.
In the long-term clinical trial with tretinoin cream, erythema and peeling/dryness were the most reported side effects in the tretinoin cream group with only 5 of 110 patients from this group withdrawing because of adverse events (erythema and peeling).
The skin of certain sensitive individuals, particularly those with fair complexions, may become excessively red, edematous, blistered or crusted when exposed to tretinoin cream. Pain, burning sensation, tenderness, irritation or pruritus have also been occasionally reported. If any of these effects occur, the medication should be discontinued until the integrity of the skin has been restored or the treatment schedule adjusted to the level the patient can tolerate. Temporary hyper- or hypopigmentation has been reported with repeated application of tretinoin. To date, all adverse clinical effects of tretinoin encountered have been reversible upon discontinuance of therapy. In many instances, reinstitution of therapy with tretinoin failed to produce the adverse effect previously experienced.
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Only available by prescription.
