What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Aubagio (Teriflunomide)
Prescription Required
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Product Details
Description
Aubagio is a specialty medication for the treatment of Multiple Sclerosis (MS). MS is a chronic, debilitating condition that affects the nervous system. It can cause symptoms throughout the entire body. When someone has MS, their immune system attacks their nervous system and causes permanent damage.
It is not known exactly what causes MS. However, there are likely various factors, including genetic and environmental causes. Aubagio works by decreasing the activity of the immune system, and protecting the nerve cells.
Fact Table
Formula
C12H9F3N2O2
License
US FDA, EU EMA
Bioavailability
100%
Legal status
Rx-only
Chemical Name
Teriflunomide
Elimination half-life
2 weeks
Dosage (Strength)
7mg, 14mg
Pregnancy
Consult Doctor
Brands
Aubagio
Protein binding
More than 99.3%
PubChem CID
54684141
MedlinePlus
a613010
ChEBI
68540
ATC code
L04AA31
DrugBank
DB08880
KEGG
D10172
Routes of administration
By mouth
Directions
The dosage of Aubagio is 7-14 mg by mouth once daily with or without food. Take this medication exactly as prescribed by your doctor.
Ingredients
The active ingredient in this drug is teriflunomide.
Interactions
Common drug-drug interactions may include:
- Abrocitinib
- Alpelisib
- Amodiaquine
- Asunaprevir
- Atogepant
- BCG Products
- Bendamustine
- Berotralstat
- Bile Acid Sequestrants
- Brincidofovir
- Charcoal, Activated
- Cladribine
- Coccidioides immitis Skin Test
- COVID-19 Vaccine
- Dengue Tetravalent Vaccine
- Denosumab
- Elagolix
- Elagolix, Estradiol, and Norethindrone
- Elbasvir and Grazoprevir
- Eluxadoline
- Erlotinib
- Influenza Virus Vaccines
- Leflunomide
- Live Vaccine
- Natalizumab
- PAZOPanib
- Pimecrolimus
- Poliovirus Vaccine
- Polymethylmethacrylate
- Rabies Vaccine
- Revefenacin
- Rosuvastatin
- Rubella- or Varicella-Containing Live Vaccines
- Ruxolitinib
- Selexipag
- Sipuleucel-T
- Tacrolimus
- Talimogene Laherparepvec
- Tertomotide
- Topotecan
- Typhoid Vaccine
- Ubrogepant
- Vaccines, Inactivated
- Voxilaprevir
- Yellow Fever Vaccine
Cautions
Do not take this drug if you are taking cholestyramine or activated charcoal.
Your doctor should monitor your blood cell counts while you take this drug.
Stop the drug immediately and call your doctor if you develop a rash.
Side Effects
Tell your doctor if you have any of the following adverse reactions while taking this drug:
- Acute hepatic failure
- Alopecia
- Anaphylaxis
- Angioedema
- Arthralgia
- Colitis
- Cytomegalovirus disease
- Diarrhea
- Drug reactions with eosinophilia and systemic symptoms
- Exacerbation of psoriasis
- Headache
- Hepatic injury
- Hypersensitivity reaction
- Hypertension
- Hypophosphatemia
- Increased serum alanine aminotransferase
- Interstitial pulmonary disease
- Jaundice
- Lymphocytopenia
- Nail disease
- Nausea
- Neutropenia
- Pancreatitis
- Paresthesia
- peripheral neuropathy
- Psoriasis
- Pustular psoriasis
- Stevens-Johnson syndrome
- Thrombocytopenia
- Toxic epidermal necrolysis
- Tuberculosis
References
- Aubagio [package insert]. Cambridge, MA: Genzyme Corporation; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13217
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