What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Letairis (Ambrisentan)

Sezzle
Brand

Letairis (Ambrisentan)

Prescription Required

Strength
Qty
10mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

Generic Equivalent - Letairis (Ambrisentan)

Prescription Required

Strength
Qty
10mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details

    Description

    Your healthcare provider may prescribe Letairis to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that supply the lungs. It belongs to a class of drugs known as endothelin receptor antagonists, which block the effects of endothelin, a substance that narrows blood vessels.

    Letairis helps to relax and widen the blood vessels in the lungs by inhibiting the action of endothelin. This reduces the strain on the heart and improves exercise capacity in individuals with PAH.


    Fact Table

    Formula

    C22H22N2O4

    License

    US FDA, EU EMA

    Bioavailability

    Undetermined

    Legal status

    Rx-Only

    Chemical Name

    Ambrisentan

    Elimination half-life

    15 hours (terminal)

    Dosage (Strength)

    10mg

    Pregnancy

    Consult Doctor

    Brands

    Letairis

    Protein binding

    99%

    PubChem CID

    6918493

    MedlinePlus

    a612023

    ChEBI

    135949

    ATC code

    C02KX02

    DrugBank

    C02KX02

    KEGG

    D07077

    Routes of administration

    By mouth

    Directions

    The usual dosage is 5 mg by mouth once daily. The dosage can be increased every four weeks.

    Letairis is typically taken orally once daily, with or without food. The dosage may vary depending on the individual's response to treatment and other factors, as determined by a healthcare professional.

    Take this drug exactly as prescribed. If a dose is missed, it should be taken as soon as possible unless it is close to the next scheduled dose.

    Ingredients

    The active ingredient in Letairis is ambrisentan.

    Interactions

    The most common drug-drug interactions may include:

    • CycloSPORINEs
    • Darolutamide
    • Eltrombopag
    • Encorafenib
    • Gemfibrozil
    • Leflunomide
    • Leniolisib
    • Pretomanid
    • Sparsentan
    • Teriflunomide
    • Trofinetide
    • Voclosporin

    Cautions

    Tell your healthcare team if you are pregnant or plan to become pregnant. Do not take this drug during pregnancy, as it may cause harm to the fetus. Women of childbearing age should use contraception while taking Letairis and for a certain period after stopping the medication.

    Letairis can cause severe liver injury, so regular monitoring of liver function is necessary during treatment.

    Individuals with pre-existing liver disease or elevated liver enzymes should inform their healthcare provider before starting Letairis.

    Letairis may cause fluid retention or swelling. Tell your doctor if you have a history of heart failure.

    Side Effects

    Common side effects may include:

    • Anemia
    • Bronchitis
    • Cardiac failure
    • Cough
    • Decreased hematocrit
    • Decreased hemoglobin
    • Dizziness
    • Dyspepsia
    • Fatigue
    • Flushing
    • Fluid retention
    • Headache
    • Hypersensitivity
    • Hypotension
    • Increased liver enzymes
    • Nasal congestion
    • Nausea
    • Oligospermia
    • Peripheral edema
    • Sinusitis
    • Vomiting
    • Weakness

    References

    Letairis [package insert]. Foster City, CA: Gilead; 2019.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13858

  • Product Reviews

Processing..

Please wait while the page is loading. Do not hit refresh or the browser back button to avoid any loss of information.

If you have any questions or concerns, please contact our Customer Service team via the chat option on our website or calling us toll free at: 1-800-891-0844