What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Letairis (Ambrisentan)
Prescription Required
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Product Details
Description
Your healthcare provider may prescribe Letairis to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that supply the lungs. It belongs to a class of drugs known as endothelin receptor antagonists, which block the effects of endothelin, a substance that narrows blood vessels.
Letairis helps to relax and widen the blood vessels in the lungs by inhibiting the action of endothelin. This reduces the strain on the heart and improves exercise capacity in individuals with PAH.
Fact Table
Formula
C22H22N2O4
License
US FDA, EU EMA
Bioavailability
Undetermined
Legal status
Rx-Only
Chemical Name
Ambrisentan
Elimination half-life
15 hours (terminal)
Dosage (Strength)
10mg
Pregnancy
Consult Doctor
Brands
Letairis
Protein binding
99%
PubChem CID
6918493
MedlinePlus
a612023
ChEBI
135949
ATC code
C02KX02
DrugBank
C02KX02
KEGG
D07077
Routes of administration
By mouth
Directions
The usual dosage is 5 mg by mouth once daily. The dosage can be increased every four weeks.
Letairis is typically taken orally once daily, with or without food. The dosage may vary depending on the individual's response to treatment and other factors, as determined by a healthcare professional.
Take this drug exactly as prescribed. If a dose is missed, it should be taken as soon as possible unless it is close to the next scheduled dose.
Ingredients
The active ingredient in Letairis is ambrisentan.
Interactions
The most common drug-drug interactions may include:
- CycloSPORINEs
- Darolutamide
- Eltrombopag
- Encorafenib
- Gemfibrozil
- Leflunomide
- Leniolisib
- Pretomanid
- Sparsentan
- Teriflunomide
- Trofinetide
- Voclosporin
Cautions
Tell your healthcare team if you are pregnant or plan to become pregnant. Do not take this drug during pregnancy, as it may cause harm to the fetus. Women of childbearing age should use contraception while taking Letairis and for a certain period after stopping the medication.
Letairis can cause severe liver injury, so regular monitoring of liver function is necessary during treatment.
Individuals with pre-existing liver disease or elevated liver enzymes should inform their healthcare provider before starting Letairis.
Letairis may cause fluid retention or swelling. Tell your doctor if you have a history of heart failure.
Side Effects
Common side effects may include:
- Anemia
- Bronchitis
- Cardiac failure
- Cough
- Decreased hematocrit
- Decreased hemoglobin
- Dizziness
- Dyspepsia
- Fatigue
- Flushing
- Fluid retention
- Headache
- Hypersensitivity
- Hypotension
- Increased liver enzymes
- Nasal congestion
- Nausea
- Oligospermia
- Peripheral edema
- Sinusitis
- Vomiting
- Weakness
References
Letairis [package insert]. Foster City, CA: Gilead; 2019.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13858
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