What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Breo Ellipta (Fluticasone Furoate & Vilanterol Trifenatate)
Also Known as Relvar Ellipta
Prescription Required
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Product Details
Description
BREO ELLIPTA (Umeclidinium) is a prescription that contains a combination of medications and is prescribed to treat asthma and chronic obstructive pulmonary disease (COPD). Asthma and COPD are diseases of the lungs that make it difficult for a person to breathe. BREO ELLIPTA is a daily medication that helps to reduce some of the symptoms like shortness of breath, coughing, and wheezing.
Directions
The usual dosage is one inhalation once daily when using BREO ELLIPTA for cough and the reduction of other symptoms.
After inhalation, rinse the mouth with water and do not swallow. If the mouth is not rinsed after use, the risk of oropharyngeal candidiasis (oral thrush) may increase.
BREO ELLIPTA should be taken every day. It is not a rescue medication and should not be used for the relief of acute bronchospasm. In the case of acute symptoms like shortness of breath, an inhaled medication like albuterol should be used for relief instead of a maintenance inhaler like BREO ELLIPTA.
If used regularly, BREO ELLIPTA will reduce the severity of asthma and COPD symptoms and reduce the need for a rescue inhaler.
Fact Table
Formula
C51H62Cl2F3NO11S
License
EU EMA
Bioavailability
15.2%
Legal status
US: RX Only
Chemical Name
Fluticasone Furoate & Vilanterol Trifenatate
Elimination half-life
24 hours
Dosage (Strength)
184/22mcg(200/25mcg) (30 doses/inhaler), 92/22mcg(100/25mcg) (30 doses/inhaler)30 days 100-25mcg 30 (1 inhaler), INST 14days 100-25mcg 28 (1 inhaler)
Pregnancy
Consult a doctor
Brands
Breo Ellipta
Protein binding
93%
PubChem CID
71306415
MedlinePlus
a603017
ChEBI
75043
ATC code
R03AK10
DrugBank
DB08906, DB09082
KEGG
D10501
Routes of administration
Inhaled
Ingredients
Fluticasone furoate
Fluticasone is an inhaled corticosteroid medication (ICS). Corticosteroids are signaling molecules that reduce inflammation. During bronchospasms, the airways of the lungs are often swollen and inflamed, and regular usage of an ICS decreases this.
Vilanterol
Vilanterol is a long-acting beta2-agonist (LABA). Beta receptors are present on the surface of muscle cells in the lungs. By activating these receptors, vilanterol relaxes the muscles of the airway, making it easier to breathe.
Cautions
The usage of BREO ELLIPTA may increase the risk of pneumonia and other bronchial infections in certain patients.
BREO ELLIPTA may rarely cause a paradoxical reaction where the airways spasm, making it harder to breathe. If this happens while taking BREO ELLIPTA, stop the medication and tell your physician.
BREO ELLIPTA should be used with caution in patients with a history of cardiovascular disorders.
BREO ELLIPTA should be used with caution in diabetic patients or those with a history of hypokalemia.
Speak with your physician for a full list of warnings and precautions.
Side Effects
Common adverse effects of BREO ELLIPTA include:
- Arthralgia
- Back pain
- Bronchitis
- Cough
- Dysphonia
- Headache
- Hypertension
- Influenza
- Nasopharyngitis
- Oral candidiasis
- Oropharyngeal pain
- Pharyngitis
- Pneumonia
- Pyrexia
- Sinusitis
- Upper respiratory tract infection
References
- Breo Ellipta [package insert].Research Triangle Park, NC: GlaxoSmithKline, 2019
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13156
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