What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Evista (Raloxifene)
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Product Details
Description
EVISTA (Raloxifene) is a medication prescribed for one or more of the following:
- Treat or prevent osteoporosis in women who have gone through menopause.
- Reduce the risk of invasive breast cancer in women who have gone through menopause and have osteoporosis.
- Reduce the risk of invasive breast cancer in women who have gone through menopause and are at risk of developing invasive breast cancer.
EVISTA is an estrogen agonist and antagonist, meaning it activates or deactivates certain estrogen receptors based on their location in the body. EVISTA is also known as a selective estrogen receptor modulator (SERM).
EVISTA agonizes estrogen receptors in the bone, causing a reduction in the normal breakdown of bone that happens during bone turnover. By decreasing the breakdown of bone, EVISTA increases bone mineral density.
EVISTA helps to prevent invasive breast cancer because it blocks the actions of estrogen in certain breast tissue that may become cancerous when exposed to high levels of estrogen over time.
Fact Table
Formula
C28H27NO4S
License
EU EMA, US FDA
Bioavailability
2%
Legal status
RX Only
Chemical Name
Raloxifene
Elimination half-life
Single dose: 28 hours, Multi-dose: 33 hours
Dosage (Strength)
60mg (28 or 84 tablets)
Pregnancy
Consult a doctor
Brands
Evista
Protein binding
Greater than 95%
PubChem CID
5035
MedlinePlus
a698007
ChEBI
8772
ATC code
G03XC01
DrugBank
DB00481
KEGG
D08465
Routes of administration
By mouth (tablets)
Directions
The normal EVISTA dosage is a 60 mg tablet by mouth once daily.
Ingredients
The active ingredient in EVISTA generic is raloxifene.
Cautions
Your doctor should not prescribe EVISTA for the treatment of invasive breast cancer, to reduce the recurrence of breast cancer, or to reduce the risk of noninvasive breast cancer.
Do not use EVISTA if you have a history of clotting disorders, including venous thromboembolism (VTE), pulmonary embolism (PE), or retinal vein thrombosis.
EVISTA should not be used by women who are pregnant, trying to become pregnant or mothers who are nursing. EVISTA should not be used in women who have not undergone menopause.
EVISTA should not be used along with systemic estrogen therapy.
Side Effects
Some of the most common adverse reactions that can occur when taking EVISTA include:
- Arthralgia
- Flu-like symptoms
- Hot flashes
- Leg cramps
- Peripheral edema
- Sweating
Speak with your doctor or pharmacist before starting EVISTA to learn about the full list of side effects that may apply to you.References
- Evista [package insert]. Indianapolis, IN 46285: Eli Lilly; 2007.
- Mayo Clinic, Osteoporosis, Retrieved April 2020
- Hopkins Medicine, Arthralgia, Retrieved April 2020
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1516
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