What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Exforge (Amlodipine / Valsartan)
Prescription Required
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Product Details
Description
Exforge (amlodipine and valsartan) is a prescription medication used to treat high blood pressure in patients whose blood pressure is not controlled with only one medication and as starting therapy in patients who will most likely need more than one medication to lower their blood pressure.
Fact Table
Formula
C20H25ClN2O5•C6H6O3S
License
EU EMA, US DailyMed
Bioavailability
25%
Legal status
Rx-Only
Chemical Name
Amlodipine/valsartan
Elimination half-life
6 hours
Dosage (Strength)
5/160mg, 10/160mg, 10/320 mg
Pregnancy
Consult Doctor
Brands
Exforge
Protein binding
Over 95%
PubChem CID
11354874
MedlinePlus
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ChEBI
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ATC code
C09DB01
DrugBank
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KEGG
D09745
Routes of administration
By mouth
Directions
Exforge (amlodipine/valsartan) comes in 5 mg/160 mg, 10 mg/160 mg, 5 mg/320 mg, and 10 mg/320 mg oral tablets.
Your doctor will recommend an appropriate dose. Follow your doctor instructions on how to take Exforge and carefully read the information that comes with your prescription. If you have any questions or concerns, don't hesitate to reach out to your doctor or pharmacist.
Ingredients
Exforge contains amlodipine, a dihydropyridine calcium channel blocker, and valsartan, an angiotensin II receptor blocker. All Exforge tablets also contain inactive ingredients such as colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose. The 5 mg/320 mg and 10 mg/320 mg tablets also contain iron oxide yellow and sodium starch glycolate. Hypromellose, iron oxides, polyethylene glycol, talc, and titanium dioxide make up the film coating.
Contraindications
Do not take Exforge if you are allergic to valsartan, amlodipine, or any of its other ingredients or excipients.
If you have diabetes, do not take Exforge with aliskiren.
Cautions
WARNING: FETAL TOXICITY
See full prescribing information for complete boxed warning.
- When pregnancy is detected, discontinue Exforge as soon as possible.
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
- Before you start treatment with Exforge medication, the following should be discussed with your doctor:
- Your medications
- Your allergies
- Your medical history and current health problems
- If you are pregnant or plan to become pregnant
- If you are breastfeeding or plan to breastfeed
- Exforge can cause low blood pressure, especially in those who are volume depleted.
- Exforge can worsen chest pain and a heart attack can occur with initiation or dosage increase. The risk is greater in patients who have severe obstructive coronary artery disease.
- Exforge can cause kidney problems.
- Exforge can cause elevated potassium levels.
Side Effects
Contact your doctor right away if you experience bothersome or persistent side effects. Exforge side effects include peripheral edema, nasopharyngitis, upper respiratory tract infection, and dizziness; these are not all the side effects that can occur with Exforge use.
Reference:
Exforge (amlodipine and valsartan) tablets, for oral use. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9877
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