What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Lialda (Mesalamine)

Also Known as Mezavant

Sezzle
Brand

Lialda (Mesalamine)

Prescription Required

Strength
Qty
1200mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

Generic Equivalent - Lialda (Mesalamine)

Prescription Required

Strength
Qty
1200mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details

    Description

    LIALDA (Mesalamine) is a prescription medication prescribed to treat Crohn's disease and Ulcerative Colitis. Both of these conditions fall under the term Inflammatory Bowel Disease (IBD).

    IBD is a disease that affects the gastrointestinal tract, which includes the esophagus, stomach, small intestine, and large intestine. Crohn's disease typically affects both the small and large intestines, while Ulcerative Colitis affects only the large intestine.

    People with IBD have chronic inflammation in either the large intestine or both the large and small intestines. During inflammation, cells become swollen and enlarged, causing pain and reducing the ability of these organs to absorb nutrients from food. LIALDA blocks certain chemicals that intestinal cells use to signal inflammation, including cyclooxygenase and prostaglandins. By inhibiting these chemicals, LIALDA reduces inflammation for people with IBD and helps to treat and prevent symptoms.


    Fact Table

    Formula

    C7H7NO3

    License

    FDA approved

    Bioavailability

    Orally: 20–30% (delayed-release tablets), varies by formulation

    Legal status

    Prescription drug

    Chemical Name

    Mesalamine

    Elimination half-life

    0.5–1.5 hours (mesalamine), 5–10 hours (N-acetyl-5-aminosalicylic acid)

    Dosage (Strength)

    Tablets (1.2 g), Suppositories (500 mg, 1 g), Enema (4 g/60 mL)

    Pregnancy advice

    Consult a doctor – Category B (US)

    Brands

    Lialda, Asacol, Pentasa, Apriso, others

    Protein binding

    43%

    PubChem CID

    4075

    MedlinePlus

    a688021

    ChEBI

    CHEBI:6775

    ATC code

    A07EC02

    DrugBank

    DB00244

    KEGG

    D00377

    Routes of administration

    Oral, Rectal

    Directions

    The dose of LIALDA can vary based on what is being treated. Take LIALDA exactly as prescribed by your doctor.

    The usual dosage is 2.4 g to 4.8 g once daily by mouth with food. The length of treatment is typically 8 weeks to induce remission.

    Ingredients

    The active ingredient in LIALDA is mesalamine.

    LIALDA generic cannot always be interchanged with other brand names since they each contain different amounts of the active ingredient and were studied under different conditions. Speak with your doctor or pharmacist before switching brands.

    Cautions

    Tell your doctor if you have a history of cardiovascular disease. Some patients have experienced myocarditis and pericarditis while taking LIALDA.

    Some patients may experience acute intolerance syndrome that is difficult to distinguish from an IBD flare-up. Symptoms include abdominal pain, cramping, diarrhea, fever, headache, and rash. If you start taking LIALDA and experience a new onset of these symptoms, tell your doctor and you may need to stop LIALDA.

    Side Effects

    Some of the most common adverse reactions that people experience when they take LIALDA include:

    • Alopecia
    • Headache
    • Increase liver enzymes
    • Pancreatitis
    • Pruritus
    • Worsening of Ulcerative Colitis

    All of the above-listed side effects occurred in greater than 1% of people who took LIALDA during the clinical trials in which the drug gained approval. For a full list of side effects, speak with your doctor or pharmacist.

    References

    1. Lialda [package insert]. Wayne, PA: Shire; 2009.
    2. Mayo Clinic, Inflammatory bowel disease (IBD), March 03, 2020, Retrived April 2020
    3. Mayo Clinic, Itchy skin (pruritus), Dec, 2018, Retrived April 2020


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9630

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