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Estalis (Estradiol / Norethindrone)

Brand

Estalis (Estradiol / Norethindrone)

Prescription Required

Strength
Qty
50 / 140mcg
50 / 250mcg

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  • Product Details

    Description

    Estalis is a prescription medication that treats menopausal symptoms in women. It is a combination of two hormones, estradiol and norethindrone acetate, which help replace the hormones the body stops making during and after menopause.

    Estradiol is a synthetic estrogen replacement, and norethindrone is a synthetic progesterone.


    Fact Table

    Formula

    C22H28O3.C18H24O2

    License

    US DailyMed

    Bioavailability

    50% - 100%

    Legal status

    Rx-Only

    Chemical Name

    Estradiol/norethisterone acetate

    Elimination half-life

    12-14 hours

    Dosage (Strength)

    LD 0.5/0.1mg 3 months, LD 1.0/0.5mg 1 month, 1.0/0.5mg 3 months

    Pregnancy

    Consult Doctor

    Brands

    Estalis

    Protein binding

    37- 61%

    PubChem CID

    none

    MedlinePlus

    a601041

    ChEBI

    -

    ATC code

    G03FA01

    DrugBank

    -

    KEGG

    -

    Routes of administration

    By mouth

    Directions

    Estalis is a patch that is applied to the skin. Your doctor determines the dose based on your needs and treatment response.

    The dosage forms include:

    • Estalis 140/50
    • Estalis 250/50

    Estalis patches are typically applied twice a week, and the patch should be left on the skin for 3-4 days of the seven-day cycle. Alternate application sites each time.

    Ingredients

    The active ingredients in Estalis are estradiol and norethindrone acetate.

    Interactions

    Common interactions with Estalis may include the following:

    • Anastrozole
    • Cosyntropin
    • Dehydroepiandrosterone
    • Exemestane
    • Fexinidazole
    • Fusidic Acid (Systemic)
    • Growth Hormone Analogs
    • Hemin
    • MetyraPONE
    • Ospemifene

    Cautions

    Do not use Estalis if you have a history of breast cancer, blood clots, or liver disease. The medication can increase the risk of these conditions.

    Tell your doctor if you experience any side effects while using Estalis, including breast lumps, unusual vaginal bleeding, or mood changes. Estalis can also increase the risk of certain cancers, such as ovarian and endometrial cancer.

    Side Effects

    Common adverse reactions may include:

    • Abdominal pain
    • Abnormal pap smear
    • Acne vulgaris
    • Application site reaction
    • Arthralgia
    • Back pain
    • Breast hypertrophy
    • Bronchitis
    • Constipation
    • Depression
    • Diarrhea
    • Dizziness
    • Dysmenorrhea
    • Dyspepsia
    • Emotional lability
    • Endometrial hyperplasia
    • Flatulence
    • Flu-like symptoms
    • Gastroenteritis
    • Headache
    • Hypermenorrhea
    • Infection
    • Insomnia
    • Leukorrhea
    • Limb pain
    • Mastalgia
    • Menstrual disease
    • Nasopharyngitis
    • Nausea
    • Nervousness
    • Ovarian cyst
    • Pain
    • Peripheral edema
    • Pharyngitis
    • Postmenopausal bleeding
    • Respiratory tract disease
    • Rhinitis
    • Sinusitis
    • Skin rash
    • Upper respiratory tract infection
    • Uterine fibroids
    • Vaginal hemorrhage
    • Vaginitis
    • Viral infection
    • Vulvovaginal candidiasis
    • Weakness
    • Weight gain

    References

    1. Estalis[package insert]. Dorval, Quebec: Novartis; 2014.


    Questions & Answers
    avatar
    Popular Questions

    1 month ago
    1 month ago
    While taking estradiol, it's generally advisable to avoid grapefruit and grapefruit juice, as they can interfere with the metabolism of the medication, potentially leading to increased side effects. Additionally, it's wise to limit alcohol consumption, as it can exacerbate estradiol's effects on the liver and increase the risk of side effects. Always consult your healthcare provider for personalized advice regarding diet and medication interactions.
    1 month ago
    1 month ago
    Estalis treats menopausal symptoms in women, helping alleviate discomfort such as hot flashes and mood swings by replacing hormones that the body stops producing. This is valuable for providing relief during menopause and improving overall quality of life.
    1 month ago
    1 month ago
    The formula for Estalis is C22H28O3.C18H24O2. This chemical structure is essential for the effective delivery of hormone therapy, ensuring precise hormone replacement.
    1 month ago
    1 month ago
    Estalis is available in different dosages: LD 0.5/0.1mg for 3 months, LD 1.0/0.5mg for 1 month, and 1.0/0.5mg for 3 months. These options provide flexibility to meet individual treatment needs and response.
    1 month ago
    1 month ago
    Estalis contains estradiol, a synthetic estrogen replacement, and norethindrone acetate, a synthetic progesterone. These hormones work together to balance hormone levels, which can help reduce menopausal symptoms.
    1 month ago
    1 month ago
    The bioavailability of Estalis ranges from 50% to 100%. This indicates how much of the drug reaches systemic circulation, which is crucial for ensuring the medication's effectiveness in treating symptoms.
    1 month ago
    1 month ago
    The elimination half-life of Estalis is 12-14 hours. This means it takes this amount of time for half of the drug to be cleared from the body, which is important for understanding dosing schedules and maintaining hormone levels.
    1 month ago
    1 month ago
    Estalis is administered as a patch applied to the skin, typically twice a week. This method offers a convenient and non-invasive way to deliver hormone therapy, with patches left on the skin for 3-4 days, ensuring consistent hormone delivery.
    1 month ago
    1 month ago
    Estalis has a protein binding percentage of 37-61%. This affects how the drug is distributed in the body and its duration of action, which is important for achieving the desired therapeutic effect.
    1 month ago
    1 month ago
    The active ingredients in Estalis are estradiol and norethindrone acetate. These ingredients are crucial for providing hormone replacement therapy to alleviate menopausal symptoms effectively.
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    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 11729

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