Prescription Required
September 11, 2021 by Erin C. (Texas, United States)
“Very easy to use. Great value for the money.”
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Estrogel (Estradiol Gel)
Also Known as Oestrogel
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Product Details
Description
Benefits and Use of Estrogel
Estradiol gel is a synthetic female hormone and is absorbed through the skin and enters the bloodstream. It is used by women to help reduce vaginal symptoms such as burning, itching or vaginal dryness. Estrogel helps in reduction of menopause symptoms.
When treating only vaginal symptoms using Estrogel, it is better to apply products directly inside the vagina or around it as estrogen taken orally may get absorbed through the skin and increase the risk of side effects due to more estrogen being absorbed.
You can buy Estrogel from Canada Pharmacy. Make sure to use Estrogel coupons to enjoy great discounts.
Directions
Once you are prescribed and buy Estradiol gel, the gel is applied to clean and dry skin on the upper thigh area or as directed by your physician. It is usually applied once daily. You can switch between the left and right thigh with each application.
Do not apply this gel to the breast or face or in or around the vagina.
Avoid applying Estrogel to the broken or irritated skin.
Do not allow others to help you apply this medication.
The dosage of this drug depends on the severity of your medical condition and your response to treatment.
After using this medication, make sure that your hands are washed thoroughly with soap to avoid the risk of accidentally spreading it from your hands to someone else. Wait a few minutes after the application of this drug; let it dry and then dress and cover yourself up. Make sure to cover this application site with a cloth to prevent others from touching it.
Wait at least 1 hour to allow others to touch your skin and if they do accidentally touch the area of the drug, have them wash their hands right away. Use this drug regularly to get more benefits.
Ingredients
The main ingredients include Estradiol, purified water, alcohol, triethanolamine, and carbomer 934P.
Cautions
- Let your physician know about the medical treatments and medicines you are using.
- Let your doctor know if you have any allergies before using it.
- Tell your doctor about the medical history of the family including vaginal bleeding of unknown causes, hormone problems, or blood disorders.
Side Effects
Some common side effects of this drug include:
- Headache
- Breast pain
- Irregular vaginal bleeding or spotting
- Stomach/abdominal cramps, bloating
- Nausea and vomiting
- Hair loss
However, if you undergo any serious side effects as mentioned below then notify your doctor immediately.- Breast lumps
- Unusual vaginal bleeding
- Dizziness and faintness
- Changes in speech
- Severe headaches
- Chest pain
- Shortness of breath
- Pain in your legs
- Changes in vision
- Vomiting
Some very rare but more serious side effects include:- Breast cancer
- Cancer of the uterus
- Stroke
- Heart attack
- Blood clots
- Gallbladder disease
- Ovarian cancer
Notify your doctor right away if you undergo any side effects.Fact Table
Formula
C18H24O2
License
EU EMA
Bioavailability
Oral: less than 5%
Legal status
RX Only
Chemical Name
Estradiol
Elimination half-life
Oral: 13–20 hours, Sublingual: 8–18 hours, Topical (gel): 36.5 hours
Dosage (Strength)
0.06% get (80 grams)
Pregnancy
Consult a doctor
Brands
Estrogel, Estradiol Transdermal Cream
Protein binding
98%
PubChem CID
5757
MedlinePlus
a601121
ChEBI
16469
ATC code
G03CA03
DrugBank
DB00783
KEGG
D00105
Routes of administration
Inserted
Popular Questions
Estrogel can be applied either in the morning or at night, as long as you choose a consistent time each day to maintain stable hormone levels. It's best to follow your healthcare provider's specific instructions regarding the timing of application.
The best place to apply estradiol gel is typically on clean, dry, and intact skin on the upper arm, shoulder, or thigh. It is important to follow your healthcare provider's instructions and avoid applying the gel to areas where it can be rubbed off easily or where it might come into contact with other people.
The formula of the main ingredient, Estradiol, is C18H24O2. Understanding the chemical formula can help users and healthcare providers understand the composition and structure of the active ingredient, which is crucial for ensuring compatibility with other medications and understanding its pharmacological effects.
The elimination half-life of Estrogel when used topically is 36.5 hours. The elimination half-life indicates how long the drug stays active in the body, which helps in determining dosing schedules and ensuring consistent therapeutic effects.
The protein binding percentage of Estradiol in Estrogel is 98%. High protein binding indicates that most of the drug is bound to plasma proteins, affecting its distribution and elimination in the body.
Estradiol gel, used for hormone replacement therapy, may cause weight changes in some individuals, but weight gain is not a universal side effect. The impact on weight can vary, with some users experiencing weight gain, weight loss, or no change at all, influenced by factors such as dosage, individual metabolism, and lifestyle. Always consult a healthcare provider for personalized advice and monitoring.
Estrogel is licensed under the EU EMA. This license indicates that the product has been reviewed and approved by the European Medicines Agency, ensuring it meets high standards for safety, efficacy, and quality.
The KEGG identifier for Estradiol is D00105. This identifier can be used to access comprehensive information about the drug's metabolic pathways and interactions.
Estrogel should be applied to clean and dry skin on the upper thigh area, usually once daily, alternating between the left and right thigh. Proper application ensures maximum absorption and effectiveness while minimizing side effects.
View allThe bioavailability of Estrogel when taken orally is less than 5%. This low bioavailability means that very little of the drug is absorbed into the bloodstream when taken orally, which is why it is applied topically to be effective.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9863
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Product Reviews
5Out of 5.0
Overall Rating100%of customers that
buy this product give
it a 4 or 5-Star rating.July 15, 2021 by Paula K. (California, United States)“Excellent price compared to stats.”May 16, 2019 by Janis R. (TX, United States)“Easy to apply, and works beautifully”February 21, 2019 by A Reviewer (NM, United States)“Great product”
