What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Halaven (Eribulin)

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Brand

Halaven (Eribulin)

Prescription Required

Strength
Qty
1mg / 2ml

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  • Product Details

    Description

    Your doctor may prescribe Halaven for the treatment of metastatic breast cancer and advanced liposarcoma. It is typically prescribed for patients who have previously received other chemotherapy treatments.

    Eribulin belongs to a class of drugs known as microtubule dynamics inhibitors. It prevents the growth and replication of cancer cells, leading to their death.

    Fact Table

    Formula

    C40H59NO11

    License

    US FDA, EMA

    Bioavailability

    Not applicable (intravenous administration)

    Legal status

    Prescription only (?)

    Chemical Name

    (2S)-11-[(2R)-2-[(2S,3R)-3-[(2S,3R)-3-[(1S,2S)-2-[(2R,3S)-3-[(2R,3S)-3-Isopropyl-5-oxotetrahydrofuran-2-yl]pyrrolidin-2-yl]cyclopropyl]tetrahydrofuran-2-yl]-1-methoxyethyl]-3-methoxypropyl]-3-isopropoxy-4,5-dimethylpyrrolidin-2-yl]methoxy]-15-oxabicyclo[9.3.1]pentadec-9-ene-2-carboxylic acid

    Elimination half-life

    40 hours

    Dosage (Strength)

    0.88 mg/mL solution for injection

    Pregnancy

    Contraindicated

    Brands

    Halaven

    Protein binding

    49-65%

    PubChem CID

    16720671

    MedlinePlus

    a611049

    ChEBI

    CHEBI:71161

    ATC code

    L01XX41

    DrugBank

    DB04845

    KEGG

    D08997

    Routes of administration

    Intravenous

    Directions

    Halaven is administered via intravenous injection. The usual dosage is based on the patient's body surface area and is typically given on days 1 and 8 of a 21-day cycle. A healthcare professional administers the injection in a clinical setting.

    Ingredients

    The active ingredient in Halaven is eribulin.

    Interactions

    Common drug-drug interactions may include:

    • Adagrasib
    • Amiodarone
    • Amisulpride
    • Anagrelide
    • Apomorphine
    • Aripiprazole
    • Aripiprazole Lauroxil
    • Arsenic Trioxide
    • Atazanavir
    • Azithromycin
    • Bepridil
    • Buprenorphine
    • Buserelin
    • Ceritinib
    • Chloroquine
    • Cisapride
    • Citalopram
    • Clarithromycin
    • Clofazimine
    • Clothiapine
    • Clozapine
    • Crizotinib
    • Dabrafenib
    • Dasatinib
    • Degarelix
    • Delamanid
    • Deslorelin
    • Deutetrabenazine
    • Dexmedetomidine
    • Domperidone
    • Donepezil
    • Dronedarone
    • Efavirenz
    • Encorafenib
    • Entrectinib
    • Escitalopram
    • Etrasimod
    • Fexinidazole
    • Fingolimod
    • Fluconazole
    • Fluoxetine
    • Formoterol
    • Foscarnet
    • Fostemsavir
    • Gepirone
    • Givinostat
    • Glasdegib
    • Gonadorelin
    • Goserelin
    • Histrelin
    • Hydroxychloroquine
    • Hydroxyzine
    • Iloperidone
    • Inotuzumab Ozogamicin
    • Itraconazole
    • Ivabradine
    • Ivosidenib
    • Ketoconazole
    • Lefamulin
    • Lenvatinib
    • Leuprolide
    • Levofloxacin
    • Levoketoconazole
    • Lofexidine
    • Macimorelin
    • Mesoridazine
    • Methadone
    • Metronidazole
    • Mirtazapine
    • Mobocertinib
    • Moxifloxacin
    • Nafarelin
    • Nilotinib
    • Olanzapine
    • Ondansetron
    • Osilodrostat
    • Osimertinib
    • Oxaliplatin
    • Ozanimod
    • Pacritinib
    • Panobinostat
    • Paroxetine
    • Pasireotide
    • Pazopanib
    • Phenobarbital
    • Pimavanserin
    • Pimozide
    • Piperaquine
    • Pitolisant
    • Ponesimod
    • Posaconazole
    • Primidone
    • Quetiapine
    • Quizartinib
    • Relugolix
    • Ribociclib
    • Saquinavir
    • Selpercatinib
    • Sertraline
    • Sevoflurane
    • Siponimod
    • Solifenacin
    • Sotalol
    • Sparfloxacin
    • Sulpiride
    • Sunitinib
    • Tacrolimus
    • Terfenadine
    • Thioridazine
    • Trazodone
    • Triclabendazole
    • Triptorelin
    • Vandetanib
    • Vardenafil
    • Vemurafenib
    • Venlafaxine
    • Vilanterol
    • Vinflunine
    • Voclosporin
    • Ziprasidone
    • Zuclopenthixol

    Cautions

    Before starting Halaven, tell your doctor if you have a history of heart disease, liver disease, kidney problems, or low blood cell counts.

    Halaven can cause neuropathy in some patients.

    Pregnant or breastfeeding women should not use Halaven due to the potential fetal risk.

    Side Effects

    Common side effects can include:

    • Alopecia
    • Anemia, All grades
    • Anemia, Grade 3 or greater
    • Constipation
    • Fatigue
    • Febrile neutropenia
    • Hypocalcemia
    • Hypokalemia
    • Nausea
    • Neutropenia, All grades
    • Neutropenia, Grade 3 or greater
    • Peripheral neuropathy
    • Prolonged QT interval
    • Sepsis
    • Neutropenic sepsis
    • Thrombocytopenia, Grade 3 or greater

    References

    Halaven [package insert]. Nutley, NJ: Eisai; September 2022.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14615

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