Description
Your doctor may prescribe Halaven for the treatment of metastatic breast cancer and advanced liposarcoma. It is typically prescribed for patients who have previously received other chemotherapy treatments.
Eribulin belongs to a class of drugs known as microtubule dynamics inhibitors. It prevents the growth and replication of cancer cells, leading to their death.
Fact Table
|
Formula
|
C40H59NO11
|
License
|
US FDA, EMA
|
Bioavailability
|
Not applicable (intravenous administration)
|
Legal status
|
Prescription only (?)
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Chemical Name
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(2S)-11-[(2R)-2-[(2S,3R)-3-[(2S,3R)-3-[(1S,2S)-2-[(2R,3S)-3-[(2R,3S)-3-Isopropyl-5-oxotetrahydrofuran-2-yl]pyrrolidin-2-yl]cyclopropyl]tetrahydrofuran-2-yl]-1-methoxyethyl]-3-methoxypropyl]-3-isopropoxy-4,5-dimethylpyrrolidin-2-yl]methoxy]-15-oxabicyclo[9.3.1]pentadec-9-ene-2-carboxylic acid
|
Elimination half-life
|
40 hours
|
Dosage (Strength)
|
0.88 mg/mL solution for injection
|
Pregnancy
|
Contraindicated
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Brands
|
Halaven
|
Protein binding
|
49-65%
|
PubChem CID
|
16720671
|
MedlinePlus
|
a611049
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ChEBI
|
CHEBI:71161
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ATC code
|
L01XX41
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DrugBank
|
DB04845
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KEGG
|
D08997
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Routes of administration
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Intravenous
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Directions
Halaven is administered via intravenous injection. The usual dosage is based on the patient's body surface area and is typically given on days 1 and 8 of a 21-day cycle. A healthcare professional administers the injection in a clinical setting.
Ingredients
The active ingredient in Halaven is eribulin.
Interactions
Common drug-drug interactions may include:
- Adagrasib
- Amiodarone
- Amisulpride
- Anagrelide
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Atazanavir
- Azithromycin
- Bepridil
- Buprenorphine
- Buserelin
- Ceritinib
- Chloroquine
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clothiapine
- Clozapine
- Crizotinib
- Dabrafenib
- Dasatinib
- Degarelix
- Delamanid
- Deslorelin
- Deutetrabenazine
- Dexmedetomidine
- Domperidone
- Donepezil
- Dronedarone
- Efavirenz
- Encorafenib
- Entrectinib
- Escitalopram
- Etrasimod
- Fexinidazole
- Fingolimod
- Fluconazole
- Fluoxetine
- Formoterol
- Foscarnet
- Fostemsavir
- Gepirone
- Givinostat
- Glasdegib
- Gonadorelin
- Goserelin
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Iloperidone
- Inotuzumab Ozogamicin
- Itraconazole
- Ivabradine
- Ivosidenib
- Ketoconazole
- Lefamulin
- Lenvatinib
- Leuprolide
- Levofloxacin
- Levoketoconazole
- Lofexidine
- Macimorelin
- Mesoridazine
- Methadone
- Metronidazole
- Mirtazapine
- Mobocertinib
- Moxifloxacin
- Nafarelin
- Nilotinib
- Olanzapine
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Pacritinib
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Phenobarbital
- Pimavanserin
- Pimozide
- Piperaquine
- Pitolisant
- Ponesimod
- Posaconazole
- Primidone
- Quetiapine
- Quizartinib
- Relugolix
- Ribociclib
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Siponimod
- Solifenacin
- Sotalol
- Sparfloxacin
- Sulpiride
- Sunitinib
- Tacrolimus
- Terfenadine
- Thioridazine
- Trazodone
- Triclabendazole
- Triptorelin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vilanterol
- Vinflunine
- Voclosporin
- Ziprasidone
- Zuclopenthixol
Cautions
Before starting Halaven, tell your doctor if you have a history of heart disease, liver disease, kidney problems, or low blood cell counts.
Halaven can cause neuropathy in some patients.
Pregnant or breastfeeding women should not use Halaven due to the potential fetal risk.
Side Effects
Common side effects can include:
- Alopecia
- Anemia, All grades
- Anemia, Grade 3 or greater
- Constipation
- Fatigue
- Febrile neutropenia
- Hypocalcemia
- Hypokalemia
- Nausea
- Neutropenia, All grades
- Neutropenia, Grade 3 or greater
- Peripheral neuropathy
- Prolonged QT interval
- Sepsis
- Neutropenic sepsis
- Thrombocytopenia, Grade 3 or greater
References
Halaven [package insert]. Nutley, NJ: Eisai; September 2022.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 14615