What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Jadenu (Deferasirox)
Prescription Required
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Product Details
Description
If you have experienced high iron in your blood then you may have received a blood transfusion. After receiving the infusion of red blood cells, your healthcare team may prescribe you to buy Jadenu. Jadenu should only be prescribed by healthcare providers specially trained in the management of chelating agents.
Symptoms of iron overload may include:
- Abnormal heart rhythm
- Darkening of the skin
- Fatigue
- Joint pain
- Stomach pain
Iron overload is also called hemochromatosis and is a chronic condition. If left untreated, it can damage several organs.
Fact Table
Formula
C21H15N3O4
License
EU EMA, US FDA
Bioavailability
70%
Legal status
Rx Only
Chemical Name
Deferasirox
Elimination half-life
8 to 16 hours
Dosage (Strength)
90mg, 180mg, 360mg
Pregnancy
No known Risks
Brands
Exjade, Jadenu
Protein binding
99%
PubChem CID
214348
MedlinePlus
a606002
ChEBI
49005
ATC code
V03AC03
DrugBank
DB01609
KEGG
D03669
Routes of administration
By mouth
Directions
Take Jadenu exactly as prescribed by your doctor. Do not change the dose without speaking with them first. Your dose may be adjusted every 3-6 months based on lab readings of blood iron content.
Ingredients
The active ingredient in Jadenu is deferasirox, which is an iron-chelating agent.
Interactions
Tell your doctor and pharmacist about all medications you are taking before you buy Jadenu and begin on this medication. It has many potential drug interactions, including:
- Aluminum Hydroxide
- Amodiaquine
- Alosetron
- Bendamustine
- Bile Acid Sequestrants
- Busulfan
- Fosphenytoin
- Phenytoin
- Phenobarbital
- Rasagiline
- Ritonavir
- Rifampin
- Selexipag
- Theophylline
- Tizanidine
Do not start any over-the-counter medications (OTC), herbals, or supplements while on Jadenu without first speaking with your healthcare team.Cautions
Tell your doctor if you have a history of ear or ear disorders since Jadenu can worsen these problems.
Use caution if you have a history of kidney or liver problems. These effects may happen more frequently in older adults.
Stop using Jadenu immediately if a skin rash develops or if you experience breathing difficulties.
Your doctor should monitor your blood cells while taking this drug.
Side Effects
Common Jadenu side effects may include:
- Abdominal pain
- Acute pancreatitis
- Anxiety
- Cholelithiasis
- Diarrhea
- Dizziness
- Duodenal ulcer
- Dyschromia
- Edema
- Fanconi's Syndrome
- Fatigue
- Gastrointestinal hemorrhage
- Gastritis
- Increased liver enzymes
- Nausea
- Proteinuria
- Serum creatinine increase
- Skin rash
- Sleep disorder
- Vomiting
References
Jadenu [package insert]. East Hanover, NJ: Novartis; 2020.
Frequently Asked Questions about Jadenu (Deferasirox)
What is Jadenu (Deferasirox)?
Jadenu is a medication used for the treatment of chronic iron overload in patients who receive regular blood transfusions, such as those with thalassemia or sickle cell disease. It helps remove excess iron from the body.
How does Jadenu work?
Jadenu is an iron chelator, which means it binds to excess iron in the body and helps the body eliminate it through urine and stool. This reduces the risk of iron-related complications.
When is Jadenu prescribed?
Jadenu is typically prescribed when a patient has received multiple blood transfusions and has accumulated excess iron in their body, which can lead to organ damage if left untreated.
What are the common side effects of Jadenu?
Common side effects of Jadenu may include nausea, vomiting, diarrhea, abdominal pain, skin rashes, and headache. It's essential to report any side effects to your healthcare provider.
How is Jadenu taken?
Jadenu is usually taken once daily as a tablet or as an oral suspension. Your healthcare provider will determine the appropriate dose for your specific condition.
Are there any special precautions or considerations when taking Jadenu?
Yes, there are several precautions to be aware of, such as regular monitoring of your iron levels and kidney function while taking Jadenu. It's crucial to follow your healthcare provider's instructions and discuss any concerns or changes in your health.
Can Jadenu interact with other medications?
Yes, Jadenu may interact with other medications, so it's essential to inform your healthcare provider about all the medications, supplements, and herbal products you are taking to prevent potential interactions.
How long do I need to take Jadenu?
The duration of Jadenu treatment depends on your individual circumstances and the underlying condition. Your healthcare provider will determine how long you should continue taking the medication.
Can I drink alcohol while taking Jadenu?
It's generally advisable to limit or avoid alcohol consumption while taking Jadenu, as alcohol can affect your liver and may interact with the medication. Always consult your healthcare provider for specific guidance.
What should I do in case of an overdose or severe side effects?
If you suspect an overdose or experience severe side effects such as difficulty breathing, severe allergic reactions, or severe abdominal pain, seek immediate medical attention or contact a poison control center.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13225
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