What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Jakafi(Ruxolitinib)
Also Known as Jakavi
Prescription Required
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Product Details
Description
Jakafi is a medication prescribed to treat certain blood disorders. It is indicated for myelofibrosis, a rare bone marrow disorder, and polycythemia vera, a condition characterized by the overproduction of red blood cells.
Myelofibrosis is a chronic condition where the bone marrow is replaced by fibrous tissue, disrupting the production of blood cells. Polycythemia vera involves an abnormal increase in the production of red blood cells, which can cause complications such as blood clots.
Jakafi works by inhibiting specific enzymes called Janus kinases, which are involved in the abnormal signaling pathways associated with these blood disorders. By targeting these enzymes, Jakafi helps to reduce symptoms such as enlarged spleen, anemia, and constitutional symptoms, improving the overall quality of life.
Fact Table
Formula
C17H18N6
License
EU EMA
Bioavailability
95%
Legal status
Rx-Only
Chemical Name
Ruxolitinib
Elimination half-life
2.8-3 hours
Dosage (Strength)
5mg, 15mg, 20mg
Pregnancy
Consult Doctor
Brands
Jakafi
Protein binding
97%
PubChem CID
25126798
MedlinePlus
a612006
ChEBI
66919
ATC code
L01EJ01
DrugBank
DB08877
KEGG
D09959
Routes of administration
By mouth
Directions
Your healthcare provider determines the dosage of Jakafi. Take it exactly as directed.
Ingredients
The active ingredient in Jakafi is ruxolitinib.
Interactions
Common drug-drug interactions may include:
- 5-Aminosalicylic Acid Derivatives
- Abrocitinib
- Antithymocyte Globulin (Equine)
- Azithromycin
- Baricitinib
- BCG Products
- Brincidofovir
- Brivudine
- Chloramphenicol (Ophthalmic)
- Cladribine
- Clofazimine
- CloZAPine
- Coccidioides immitis Skin Test
- COVID-19 Vaccine
- Deferiprone
- Dengue Tetravalent Vaccine (Live)
- Denosumab
- Deucravacitinib
- Dipyrone
- Fexinidazole
- Filgotinib
- Fluconazole
- Fusidic Acid
- Inebilizumab
- Influenza Virus Vaccines
- Leflunomide
- Mumps- Rubella- or Varicella-Containing Live Vaccines
- Nadofaragene Firadenovec
- Natalizumab
- Ocrelizumab
- Ofatumumab
- Olaparib
- Pidotimod
- Pimecrolimus
- Pneumococcal Vaccines
- Poliovirus Vaccine
- Polymethylmethacrylate
- Promazine
- Rabies Vaccine
- Ropeginterferon Alfa-2b
- Sipuleucel-T
- Sphingosine 1-Phosphate (S1P) Receptor Modulator
- Tacrolimus (Topical)
- Talimogene Laherparepvec
- Tertomotide
- Tofacitinib
- Typhoid Vaccine
- Ublituximab
- Upadacitinib\
Cautions
Your risk of infection may increase while taking Jakafi.
Your doctor should monitor for the development of skin cancer during treatment.
Ask your doctor and pharmacist about all precautions.
Side Effects
Common side effects are:
- Anemia
- Basal cell carcinoma of the skin
- Bruise
- Constipation
- Cough
- Diarrhea
- Dyspnea
- Dizziness
- Edema
- Exacerbation of hepatitis B
- Fatigue
- Fever
- Flatulence
- Headache
- Hemorrhage
- Herpes simplex infection
- Herpes zoster infection
- Hypercholesteremia
- Hypertriglyceridemia
- Increased LDL cholesterol
- Increased serum alanine aminotransferase
- Increased serum aspartate aminotransferase
- Infection
- Insomnia
- Merkel cell carcinoma
- Muscle spasm
- Musculoskeletal pain
- Nausea
- Neutropenia
- Progressive multifocal leukoencephalopathy
- Serious infection
- Squamous cell carcinoma of the skin
- Thrombocytopenia
- Tuberculosis
- Urinary tract infection
- Viral infection
- Weight gain
References
Jakafi [package insert]. Wilmington, DE: Incyte Corporation; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13846
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