What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Jentadueto (Linagliptan / Metformin)
Also Known as Trajentamet
Prescription Required
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Product Details
Description
Jentadueto may be prescribed by your doctor for the treatment of type 2 diabetes mellitus. It cannot be used by people with type 1 diabetes. This drug should only be used in combination with diet and exercise.
Type 2 diabetes is a chronic condition where the blood sugar is too high because the body gradually becomes resistant to insulin over time. Symptoms may include:
- Increased thirst
- Increased urination
- Unexplained weight loss
- Vision changes
- Wounds that are slow to heal
- Fatigue
Fact Table
Formula
Linagliptin: C25H28N8O2 Metformin: C4H11N5
License
US DailyMed
Bioavailability
30% - 60%
Legal status
Rx-Only
Chemical Name
Linagliptan / Metformin
Elimination half-life
4-12 hours
Dosage (Strength)
2.5mg / 500mg, 2.5mg / 850mg, 2.5mg / 1000mg
Pregnancy
Consult Doctor
Brands
Jentadueto
Protein binding
99%
PubChem CID
Linagliptin: 10096344 Metformin: 4091
MedlinePlus
a612032
ChEBI
Linagliptin: 65369 Metformin: 6801
ATC code
A10BD11
DrugBank
Linagliptin: DB08882 Metformin: DB00331
KEGG
Linagliptin: D09566 Metformin: D04966
Routes of administration
Oral
Directions
Once you are prescribed then buy Jentadueto, take it twice daily as directed by your doctor. There are different dosages for this medication based on how well it is working.
Ingredients
The active ingredients in Jentadueto are linagliptin and metformin. There is no Jentadueto generic available.
Linagliptin works by shutting down an enzyme called DPP4, which is responsible for recycling certain hormones in the gastrointestinal tract. By shutting down this enzyme, the amount of insulin and glucose in the blood is rebalanced.
Metformin works by reducing the amount of glucose produced in the liver and by making the body more sensitive to insulin.
Interactions
Common drug-drug interactions may include:
- Alcohol
- Apalutamide
- Carbamazepine
- Clotrimazole
- Dexamethasone
- Dolutegravir
- Enzalutamide
- Fosamprenavir
- Fosphenytoin
- Glimepiride
- Glipizide
- Glyburide
- Indinavir
- Insulins
- Iodinated Contrast Agents
- Lumacaftor-ivacaftor
- Mitotane
- Morphine
- Nelfinavir
- Phenobarbital
- Phenothiazines
- Phenytoin
- Prazosin
- Primidone
- Ranolazine
- Retinoic acid
- Rifampin (rifampicin)
- Ritonavir
- Saquinavir
- Spironolactone
- St. John's Wort
Cautions
Tell your doctor if you have a history of lactic acidosis, pancreatitis, or vitamin b12 deficiency.
Tell your doctor if you suddenly develop arthritis pain in one or more joints.
This is not a full list of precautions.
Side Effects
Common Jentadueto side effects can include:
- Abdominal distress
- Abdominal pain
- Asthenia
- Cough
- Diarrhea
- Dyspepsia
- Flatulence
- Flushing
- Headache
- Increased serum lipase
- Increased uric acid
- Low blood sugar
- Low vitamin B12
- Nasopharyngitis
- Nausea
- Palpitations
- Vomiting
References
Jentadueto [package insert]. Indianapolis, IN: Boehringer; 2016.
Frequently Asked Questions about Jentadueto (Linagliptin / Metformin)
What is Jentadueto (Linagliptin / Metformin)?
Jentadueto is a combination medication used to treat type 2 diabetes. It contains two active ingredients, Linagliptin and Metformin, which work together to help control blood sugar levels.
How does Jentadueto work?
Linagliptin works by increasing the release of insulin in response to high blood sugar levels and by reducing the production of glucose by the liver. Metformin helps improve insulin sensitivity and reduces the absorption of glucose from the digestive tract.
When is Jentadueto prescribed?
Jentadueto is typically prescribed for individuals with type 2 diabetes when diet and exercise alone are not sufficient to control blood sugar levels. It is often used in combination with a healthy lifestyle and other diabetes medications.
What are the common side effects of Jentadueto?
Common side effects of Jentadueto may include nausea, diarrhea, abdominal pain, headache, and cold-like symptoms. These side effects are usually mild and temporary. However, it's essential to report any unusual or severe side effects to your healthcare provider.
How is Jentadueto taken?
Jentadueto is typically taken by mouth, usually with meals. The dosing regimen will depend on your healthcare provider's instructions and the specific strength of the medication prescribed.
Are there any special precautions or considerations when taking Jentadueto?
It is important to inform your healthcare provider about any other medications, supplements, or medical conditions you have, as they can affect the safety and effectiveness of Jentadueto. Your healthcare provider may also monitor your kidney function regularly.
Can Jentadueto interact with other medications?
Yes, Jentadueto can interact with other medications, so it's crucial to inform your healthcare provider about all the medications you are taking. They can help determine if there are any potential interactions and adjust your treatment accordingly.
How long do I need to take Jentadueto?
The duration of Jentadueto treatment will depend on your individual response and the recommendations of your healthcare provider. It is often used as a long-term medication to help manage type 2 diabetes.
Can I drink alcohol while taking Jentadueto?
It is generally advisable to limit alcohol consumption while taking Jentadueto, as alcohol can affect blood sugar levels and interact with the medication. Consult your healthcare provider for specific guidance on alcohol consumption.
What should I do in case of an overdose or severe side effects?
If you suspect an overdose or experience severe side effects such as difficulty breathing, severe allergic reactions, or unusual symptoms, seek immediate medical attention or contact your healthcare provider.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12935
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