What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Merional (Menotrophin)
Prescription Required
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Product Details
Description
Merional is a medication used to treat adult women with infertility issues who have not responded to treatment with clomiphene citrate. It is used to stimulate the development of follicles in patients who are receiving assisted reproductive technologies (ART) like in-vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and zygote intrafallopian transfer (ZIFT). It may also be given along with human Chorionic Gonadotropin (hCG) to stimulate the production of sperm in men with congenital or acquired hypogonadotropic hypogonadism.
Merional comes in a powder and solvent solution for injection.
Fact Table
Formula
C1014H1609N287O294S27
License
US DailyMed
Bioavailability
High Bioavailability
Legal status
Rx-only
Chemical Name
Menotropin
Elimination half-life
24 hours
Dosage (Strength)
75 IU, 76 IU, 77 IU
Pregnancy
Should not be used
Brands
Merional
Protein binding
Does not typically bind extensively to plasma protein
PubChem CID
16132296
MedlinePlus
a601002
ChEBI
6887
ATC code
G03GA02
DrugBank
DB00032
KEGG
Not Available
Routes of administration
Subcutaneous injection
Directions
Merional should be used as directed by your doctor. If you have any questions or concerns related to its use, contact your doctor or pharmacy.
Your doctor will provide more detailed information on Merional treatment.
Ingredients
The active ingredient in Merional is menotrophin BP (Human menopausal gonadotropin, HMG), purified from human urine.
Contraindications
Merional should not be administered to patients who are allergic to menotrophin or to any of the other ingredients in the medication or in patients who have hypothalamic or pituitary gland tumors.
In addition, Merional should not be administered to women with ovarian enlargement or a cyst not caused by polycystic ovarian disease, gynecological bleeding of an unknown cause, or ovarian, uterine, or mammary cancer.
Merional should not be administered when a patient is unable to achieve an effective response, including:
- In females: primary ovarian failure, malformation of sex organs that are not compatible with pregnancy, or fibroid tumors of the uterus that are not compatible with pregnancy
- In males: primary testicular insufficiency
Cautions
- Before you begin therapy with Merional, discuss the following with your doctor:
- All the medications you take
- Your allergies
- Your past medical history or current health issues
- Your pregnancy status
- Your breastfeeding status
- Ovarian hyperstimulation can occur, resulting in symptoms such as abdominal pain, abdominal swelling, severe ovarian enlargement, weight gain, shortness of breath, low urine output, nausea, vomiting, and diarrhea.
- The risk for multiple pregnancy is increased with Merional therapy.
- Pregnancy wastage by miscarriage or abortion occurs more frequently in patients who undergo stimulation of follicular growth for ovulation induction or ART compared to the normal population.
- Ectopic pregnancy occurs more often in women after receiving IVF.
- Cancers of the ovary and reproductive system have occurred in women who have received multiple infertility treatment regimens.
- Congenital malformations may occur more often after ART compared to spontaneous conceptions.
- The risk for blood clotting disorders may be further increased in women who have risk factors.
Side Effects
Ovarian cysts, injection site reactions, and headache are common Merional injection side effects; however, other side effects may also occur. Contact your doctor right away if you have side effects that bother you or won’t go away.
Looking for a competitive Merional cost? You can buy Merional online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
Reference:
Merional. Italy: IBSA Farmaceutici Italia S.r.1; 2015.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12559
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