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Nocdurna (Desmopressin)
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Product Details
Description
Nocdurna (desmopressin acetate) is available only by prescription to treat nighttime urination caused by nocturnal polyuria in adults who wake up at least two times at night to urinate.
Nocdurna comes in 27.7 mcg and 55.3 mcg tablets that are to be placed underneath the tongue to dissolve.
Fact Table
Formula
C46H64N14O12S2
License
US FDA
Bioavailability
Variable; 0.08–0.16% (by mouth)
Legal status
Rx-only
Chemical Name
Desmopressin
Elimination half-life
1.5–2.5 hours
Dosage (Strength)
25mcg, 50mcg
Pregnancy
Consult Doctor
Brands
Nocdurna
Protein binding
50%
PubChem CID
5311065
MedlinePlus
a608010
ChEBI
4450
ATC code
H01BA02
DrugBank
DB00035
KEGG
D00291
Routes of administration
Sublingually as tablets
Directions
Take Nocdurna as prescribed by your doctor. Tell your doctor or pharmacist about any questions or concerns you may have.
Dosing in women: Place one 27.7 mcg tablet underneath the tongue once daily without water. Take one hour before bedtime.
Dosing in men: Place one 55.3 mcg tablet underneath the tongue once daily without water. Take one hour before bedtime.
Ingredients
The active ingredient in Nocdurna is desmopressin acetate. Inactive ingredients include gelatin, NF (fish source), mannitol, and anhydrous citric acid.
Contraindications
Do not take Nocdurna if you:
- Have low sodium levels or a history of low sodium levels
- Have excess thirst
- Are taking loop diuretics or systemic or inhaled glucocorticoids
- Have kidney problems
- Have syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Have an illness that can cause fluid or electrolyte disturbances
- Have heart failure
- Have uncontrolled high blood pressure
Cautions
Nocdurna has the following FDA Boxed Warnings:
- Nocdurna can cause low sodium levels that can be severe and life-threatening
- Nocdurna should not be used in patients who are at risk for severe low sodium levels, including patients with excessive fluid intake, illnesses that can cause fluid or electrolyte disturbances, and in those taking loop diuretics or systemic or inhaled glucocorticoids
- Blood sodium levels should be normal before starting or resuming Nocdurna. Blood sodium should be measured within 1 week and approximately 1 month after starting therapy and periodically during treatment. Patients who are 65 years old and older and patients who are at increased risk for low sodium levels should receive more frequent monitoring.
- Nocdurna may need to be stopped temporarily or permanently in patients who develop low sodium levels.
- Before you start taking Nocdurna, inform your doctor of:
- All the medications you take
- Your allergies
- Your current health conditions and past medical history
- Your pregnancy or breastfeeding status
- Patients are recommended to limit their fluid intake from 1 hour before, or until 8 hours, after taking Nocdurna.
- Patients who are at risk of increased intracranial pressure or who have a history of urinary retention are not recommended to take Nocdurna.
Side Effects
Common Nocdurna side effects include dry mouth, low blood sodium levels, and dizziness. However, these are not all the side effects that can occur with Nocdurna treatment. Call your doctor right away if you have side effects that bother you or won’t go away.
With a valid prescription from your doctor, you can buy Nocdurna online at a competitive price at Canada Pharmacy.
Reference:
- Nocdurna. Ewing, NJ: Antares Pharma Inc.; 2020.
Popular Questions
The active ingredient is desmopressin acetate, which helps manage nighttime urination due to nocturnal polyuria by reducing urine production during sleep, providing comfort and better sleep quality for the user.
The inactive ingredients include gelatin (from a fish source), mannitol, and anhydrous citric acid. These components help in the formulation and stability of the tablet, ensuring it dissolves effectively under the tongue.
The medication should be taken sublingually, meaning the tablet is placed under the tongue to dissolve, which allows for faster absorption into the bloodstream compared to swallowing, offering quicker relief from symptoms.
The medication is available in 27.7 mcg and 55.3 mcg tablets, providing options based on the specific needs and prescription requirements of the user, ensuring effective treatment.
The chemical formula is C46H64N14O12S2, which represents the complex structure of desmopressin acetate, crucial for its function in regulating urine production.
The medication is Rx-only, meaning it is available only with a prescription, ensuring proper medical oversight and usage for safety and effectiveness.
The bioavailability is variable, ranging from 0.08% to 0.16% by mouth, indicating the proportion of the drug that enters circulation and can have an active effect, emphasizing the importance of the sublingual route for higher effectiveness.
The elimination half-life is between 1.5 to 2.5 hours, which influences the dosing schedule and helps maintain optimal levels of the drug in the system for continuous therapeutic effect.
The protein binding is 50%, which affects the distribution and duration of action of the drug in the body, playing a role in its therapeutic efficacy.
View allWomen should place one 27.7 mcg tablet under the tongue once daily, one hour before bedtime without water, providing a regimen that aligns with the body's natural sleep cycle for optimal effect.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13861
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