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May 16, 2025 by Rosemary K. (Ohio, United States)
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Rexulti (brexpiprazole) is classified as an atypical antipsychotic used as an adjunctive therapy to antidepressants to treat major depressive disorder (MDD) in adults and for the treatment of schizophrenia in adults and pediatric patients who are at least 13 years old.
Rexulti is available in 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg tablets.
| Fact Table | |
| Formula |
C25H27N3O2S |
| License |
US DailyMed, EU EMA, US FDA |
| Bioavailability |
95% |
| Legal status |
Rx-Only |
| Chemical Name |
Brexpiprazole |
| Elimination half-life |
91 hours |
| Dosage (Strength) |
0.25mg - 4mg |
| Pregnancy |
Consult Doctor |
| Brands |
Rexulti |
| Protein binding |
Greater than 99% |
| PubChem CID |
11978813 |
| MedlinePlus |
a615046 |
| ChEBI |
134716 |
| ATC code |
N05AX16 |
| DrugBank |
DB09128 |
| KEGG |
D10309 |
| Routes of administration |
By mouth |
Rexulti is taken by mouth once daily with or without food.
MDD in adults
Starting dose: 0.5 mg/day or 1 mg/day
Recommended dose: 2 mg/day
Max dose: 3 mg/day
Schizophrenia in adults
Starting dose: 1 mg/day
Recommended dose: 2 to 4 mg/day
Max dose: 4 mg/day
Schizophrenia in pediatric patients (13-17 years old)
Starting dose: 0.5 mg/day
Recommended dose: 2 to 4 mg/day
Max dose: 4 mg/day
The active ingredient in Rexulti is Brexpiprazole.
Do not take Rexulti if you are allergic to Brexpiprazole or any of the other ingredients in Rexulti. Discuss your allergies with your doctor.
WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS and SUICIDAL THOUGHTS AND BEHAVIORS
See full prescribing information for complete boxed warning.
Once you are prescribed and buy Rexulti, Rexulti may cause neuroleptic malignant syndrome that can cause death. Seek medical care right away if you develop a high fever, breathing problems, blood pressure changes, changes in heart rate, stiff muscles, confusion, or sweating.
Rexulti can cause uncontrolled movements of your face, tongue, or other parts of the body, even after you stop taking it.
Tell your doctor if you have diabetes. Rexulti can cause high blood sugar. Contact your doctor if you have excessive thirst or hunger, feel sick to your stomach, need to urinate more frequently, feel weak or tired, feel confused, or your breath smells fruity.
Rexulti can cause increased cholesterol and triglycerides.
This medication can cause weight gain. You should monitor your weight while being treated with Rexulti.
Rexulti can cause compulsive urges. Talk to your doctor if you have unusual urges.
Rexulti can cause low white blood cell counts.
Tell your doctor if you have blood pressure problems. Rexulti can cause a sudden drop in your blood pressure upon standing.
This medication can make you feel sleepy or dizzy, cause your blood pressure to drop, or slow your thinking and motor skills that can cause you to fall and develop fractures or other injuries.
Tell your doctor if you have seizures. Rexulti can increase your risk for seizures.
Tell your doctor about any medications you take, including prescription and over-the-counter.
The most common Rexulti side effects include:
These are not all the possible Rexulti side effects, so be sure to tell your doctor right away if you experience bothersome side effects or side effects that persist.
References:
What is Rexulti (Brexpiprazole) used for?
Schizophrenia: Helps manage symptoms like delusions, hallucinations, and disorganized thinking.
Major depressive disorder (MDD): Used in combination with antidepressants to improve mood and decrease depressive symptoms.
How does Rexulti work?
Rexulti belongs to a class of medications called atypical antipsychotics. It works by affecting the activity of dopamine and serotonin, two brain chemicals involved in mood, thought, and behavior.
What is the dosage of Rexulti?
The dosage varies depending on the condition being treated. It typically starts low and is gradually increased until the desired effect is achieved. It's crucial to follow your doctor's specific instructions.
Can I take Rexulti with other medications?
It's crucial to tell your doctor about all the medications and supplements you take, as Rexulti can interact with some of them.
Is Rexulti addictive?
There is no evidence that Rexulti is addictive. However, it's important to take it exactly as prescribed and not stop taking it suddenly without consulting your doctor.
Is Rexulti safe for pregnant or breastfeeding women?
There is limited data on the safety of Rexulti during pregnancy or breastfeeding. Talk to your doctor about the risks and benefits before taking it if you are pregnant or breastfeeding.
How long does it take for Rexulti to work?
It can take several weeks for Rexulti to reach its full effect. Be patient and continue taking your medication as prescribed even if you don't see immediate results.
What should I do if I miss a dose of Rexulti?
If you miss a dose, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
