What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tradjenta (Linagliptin)
Also Known as Trajenta
Prescription Required
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Product Details
Description
Tradjenta is classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used with diet and exercise to lower blood sugar levels in adults with type 2 diabetes.
The generic name for Tradjenta is Linagliptin.
Fact Table
Formula
C25H26N8O2
License
US FDA, EU EMA, US DailyMed
Bioavailability
~30%
Legal status
Rx-Only
Chemical Name
Linagliptin
Elimination half-life
~24 hours
Dosage (Strength)
5mg
Pregnancy
Not recommended
Brands
Tradjenta
Protein binding
75–99%
PubChem CID
10096344
MedlinePlus
a611036
ChEBI
68610
ATC code
A10BH05
DrugBank
DB08882
KEGG
D09566
Routes of administration
By mouth
Directions
Tradjenta is available as a 5 mg oral tablet. The dose of Tradjenta is 5 mg by mouth once daily with or without food.
Ingredients
The active ingredient in Tradjenta is Linagliptin, a DPP-4 inhibitor.
Contraindications
Talk to your doctor about your allergies. Do not take Tradjenta if you are allergic to linagliptin or any of the other ingredients contained in Tradjenta. Reactions such as anaphylaxis, angioedema, bronchial hyperreactivity, exfoliative skin, or urticaria have been reported.
Warnings and Precautions
- Tradjenta may interact with some medications. Before you start Tradjenta, be sure to tell your doctor about any prescription and over-the-counter medications, vitamins, and supplements you take.
- Tradjenta may cause pancreatitis. You should seek medical attention if you experience stomach pain that won't go away.
- Heart failure has been reported with other DPP-4 inhibitors. The benefits and risks should be considered if you are at risk for heart failure.
- Tradjenta can cause low blood sugar levels, especially if taken with other medications that can lower blood sugar. Monitor symptoms of low blood sugar such as sweating, nervousness, shakiness, hunger, confusion, irritability, and/or rapid heart beat. Be sure to treat low blood sugar as your doctor has instructed.
- Some people have reported joint pain while taking DPP-4 inhibitors like Tradjenta. Tell your doctor if you develop joint pain.
- A skin reaction called bullous pemphigoid may occur in patients who take DPP-4 inhibitors such as Tradjenta. Contact your doctor immediately if you develop blisters.
- Tell your doctor if you are pregnant or plan to become pregnant.
- Tell your doctor if you are breastfeeding or plan to breastfeed.
Side Effects
Tell your doctor if you experience severe side effects or side effects that are bothersome or won't go away. The most common side effects of Tradjenta (linagliptin) are:
- Cough
- Diarrhea
- Stuffy or runny nose
- Sore throat
References:
- TRADJENTA Prescribing Information. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2020.
- Tradjenta (linagliptin). Accessed November 18, 2021. https://www.tradjenta.com.
Frequently Asked Questions about Tradjenta (Linagliptin)
What is Tradjenta (Linagliptin) used for?
Tradjenta is used to treat high blood sugar levels caused by type 2 diabetes. It works by increasing insulin levels and reducing the amount of sugar released into the blood.
What should I discuss with my care team before taking Tradjenta?
Inform your care team if you have diabetic ketoacidosis, type 1 diabetes, unusual or allergic reactions to linagliptin or other substances, or if you are pregnant, planning to become pregnant, or breastfeeding.
How should I take Tradjenta?
Take Tradjenta by mouth with water, following the prescription label. It can be taken with or without food, and at the same time each day. Do not stop taking it without your care team's advice.
What if I miss a dose of Tradjenta?
If you miss a dose, take it as soon as you can. If it's almost time for your next dose, skip the missed dose and return to your regular schedule. Do not take double doses.
Are there any medications or substances that interact with Tradjenta?
Yes, interactions can occur with alcohol, certain medications for seizures, Rifabutin, Rifampin, St. John's Wort, Sulfonylureas, and more. Always inform your healthcare provider of all medications and supplements you are taking.
What should I monitor while using Tradjenta?
Regularly visit your care team for progress checks, monitor your blood sugar levels, and be aware of the symptoms of both low and high blood sugar. Carry a quick-source of sugar for low blood sugar emergencies and wear a medical ID bracelet for safety.
What are the possible side effects of taking Tradjenta?
Possible side effects include allergic reactions, heart failure symptoms, pancreatitis, skin issues, joint pain, and more. Some side effects like cough, diarrhea, runny nose, or sore throat may not require medical attention unless persistent.
How should Tradjenta be stored?
Store it at room temperature between 15 and 30 degrees C, away from heat, moisture, and light. Keep it out of reach of children and dispose of unused medication properly.
What are the dosing guidelines for Tradjenta?
The dosage varies and should be as prescribed by your doctor. The average dose for adults is 5 milligrams (mg) once a day. The dose for children must be determined by a doctor.
Are there any special instructions or precautions I should follow?
Follow your doctor’s instructions, especially regarding meal plans and exercise. Discuss alcohol use, other medications, and travel plans with your healthcare team. Be prepared for emergencies related to diabetes.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12498
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