What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Uloric (Febuxastat)
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Product Details
Description
Uloric is a prescription medication given to treat hyperuricemia, which is excess uric acid that leads to gout attacks.
Symptoms of gout are located in the joints, particularly the toe, ankle, foot, and knee joints. Symptoms may include stiffness, swelling, pain, and lumps.
Uloric works by decreasing the amount of uric acid circulating in the bloodstream, which reduces the formation of uric acid crystals in the joints. Uloric belongs to the class of medications Xanthine Oxidase Inhibitors.
Fact Table
Formula
C16H16N2O3S
License
US FDA
Bioavailability
49%
Legal status
US: RX Only
Chemical Name
Febuxastat
Elimination half-life
5 to 8 hours
Dosage (Strength)
40mg, 80mg
Pregnancy
No known risks
Brands
Uloric and Adenuric
Protein binding
99% %
PubChem CID
134018
MedlinePlus
a609020
ChEBI
31596
ATC code
M04AA03
DrugBank
DB04854
KEGG
D01206
Routes of administration
By mouth (tablets)
Directions
The starting dose of Uloric is 40 mg by mouth once daily. Your prescriber may increase the dose to 80 mg after two weeks if the response to medication is inadequate. It can be increased one more time if needed to 120 mg once daily.
Your dosage may need to be adjusted if you have kidney problems.
Ingredients
The active ingredient in Uloric is Febuxostat, which is also the name for Uloric generic.
Interactions
Uloric has drug-drug interactions with the following medications:
- Azathioprine
- Didanosine
- Mercaptopurine
- Methotrexate
- Pegloticase
- Theophylline
Cautions
Patients with established cardiovascular disease should not use Uloric unless directed by their physician. Cardiovascular disease is associated with a higher rate of cardiovascular death compared to other agents used to treat gout.
When starting Uloric, gout flares may initially increase. Additional gout medications may be used to help prevent this.
Tell your doctor if you have a history of heart or liver problems before starting Uloric.
Side Effects
Common Uloric side effects may include:
- Acute gout attack
- Arthralgia
- Hepatic insufficiency
- Increased liver enzymes
- Nausea
- Skin rash
References
Uloric [package insert]. Deerfield, IL: Takeda; 2017.
Frequently Asked Questions about Uloric (Febuxastat)
What is Uloric (Febuxastat)?
Uloric is a brand name medication that contains the active ingredient Febuxastat. It is used to treat a condition known as hyperuricemia in adults with gout.
How does Uloric work?
Uloric works by reducing the production of uric acid in the body. It inhibits the enzyme responsible for producing uric acid, thereby lowering uric acid levels in the blood.
What is Uloric used for?
Uloric is primarily used to manage gout by lowering elevated uric acid levels. It can help prevent gout attacks and reduce the risk of gout-related complications.
Can Uloric be used to treat acute gout attacks?
No, Uloric is not meant for the treatment of acute gout attacks. It is a long-term medication used to prevent gout attacks and manage hyperuricemia. Acute attacks are usually treated with other medications like nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine.
How should I take Uloric?
Uloric is typically taken once daily, with or without food. Your healthcare provider will prescribe the appropriate dose for you based on your medical condition and uric acid levels.
Are there any common side effects of Uloric?
Common side effects of Uloric may include nausea, joint pain, rash, liver function abnormalities, and increased levels of liver enzymes. It's important to report any side effects to your healthcare provider.
Can I take Uloric if I have kidney problems?
Uloric may be used in individuals with kidney problems, but the dose may need to be adjusted based on your kidney function. Your healthcare provider will determine if it's safe and appropriate for you.
Is Uloric safe for use during pregnancy or breastfeeding?
Uloric is generally not recommended during pregnancy or breastfeeding. It's important to discuss your pregnancy plans with your healthcare provider, as they can provide guidance on the potential risks and benefits.
How long does it take for Uloric to start working?
Uloric may start to lower uric acid levels within a few weeks of starting treatment. However, the full effects on preventing gout attacks may take several months. Regular monitoring by your healthcare provider is important.
Can I drink alcohol while taking Uloric?
It's generally advisable to limit alcohol consumption while taking Uloric, as alcohol can increase uric acid levels and trigger gout attacks. Consult with your healthcare provider for specific guidance regarding alcohol use.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11357
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