What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Vastarel MR (Trimetazidine)

Also Known as Vastarel MR

Sezzle
Brand

Vastarel MR (Trimetazidine)

Prescription Required

Strength
Qty
35mg

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  • Product Details

    Description

    Your doctor may prescribe Vastarel MR to manage angina, a condition where not enough oxygen gets to cardiac muscle, causing chest pain.

    Vastarel MR works by improving myocardial glucose utilization and inhibiting fatty acid oxidation. This mechanism optimizes cellular energy metabolism, safeguarding the heart against ischemia and inadequate blood supply.

    Fact Table

    Formula

    C14H22N2O3

    License

    EMA

    Bioavailability

    ~90%

    Legal status

    Prescription only (?)

    Chemical Name

    1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

    Elimination half-life

    6 hours

    Dosage (Strength)

    35 mg modified-release tablets

    Pregnancy

    Not recommended

    Brands

    Vastarel MR

    Protein binding

    16%

    PubChem CID

    5546

    MedlinePlus

    a682992

    ChEBI

    CHEBI: 322963

    ATC code

    C01EB15

    DrugBank

    DB09270

    KEGG

    D08691

    Routes of administration

    Oral

    Directions

    The recommended dosage for Vastarel MR is 35 mg orally twice daily, to be taken with meals.

    Ingredients

    The active ingredient in Vastarel MR is trimetazidine.

    Interactions

    Drug-drug interactions for Vastarel MR are not well known. Based on how this drug works, it is likely to interact with antipsychotics, antihypertensives, and medications for angina. Example include:

    Amlodipine

    Aripiprazole

    Atenolol

    Clozapine

    Diltiazem

    Haloperidol

    Hydrochlorothiazide

    Isosorbide dinitrate

    Isosorbide mononitrate

    Lisinopril

    Losartan

    Metoprolol

    Nitroglycerin

    Olanzapine

    Quetiapine

    Ranolazine

    Risperidone

    Valsartan

    Verapamil

    Ziprasidone

    Cautions

    Although Vastarel MR is not approved for use in the United States, it has approval in some other countries.

    The European Medicines Agency (EMA) advises against its use for tinnitus, vertigo, or vision disturbances.

    Caution is warranted when prescribing Vastarel MR to individuals with movement disorders such as Parkinson's disease, parkinsonian symptoms, tremors, restless legs syndrome (RLS), and other related conditions.

    Side Effects

    Abdominal pain

    Constipation

    Diarrhea

    Difficulty sleeping

    Dizziness

    Drowsiness

    Extrapyramidal symptoms (unusual movements, including trembling and shaking of the hands and fingers, twisting movements of the body, shuffling walk, and stiffness of the arms and legs), usually reversible after treatment discontinuation

    Extra heartbeats

    Fainting

    Fall

    Fast or irregular heartbeats (palpitations)

    Faster heartbeat

    Feeling of weakness

    Feeling sick (nausea)

    Flushing

    Headache

    Hives

    Indigestion

    Itching

    Leukopenia

    Lightheadedness

    Liver disease

    Low blood pressure

    Malaise (generally feeling unwell)

    Rash

    Red skin rash with blistering

    Swelling of the face, lips, mouth, tongue, or throat, which may cause difficulty in swallowing or breathing

    Thrombocytopenia

    Vertigo

    Vomiting

    References

    Vastarel MR [package insert]. Giddy, France: Les Laboratories; February 2021.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 12271

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