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The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Xeomin (IncobotulinumtoxinA)
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Product Details
Description
Xeomin (incobotulinumtoxinA) is an injectable medication used to treat or improve:
- Chronic sialorrhea in patients who are least 2 years old
- Upper limb spasticity in adults
- Upper limb spasticity (except spasticity caused by cerebral palsy) in pediatric patients who are between 2 and 17 years old
- Cervical dystonia in adults
- Blepharospasm in adults
- The appearance of moderate to severe frown lines between the eyebrows with corrugator and/or procerus muscle activity in adults
Xeomin may be given intramuscularly or by intraglandular route.
Fact Table
Formula
C6760H10447N1743O2010S32
License
US FDA, EMA
Bioavailability
Local effect only (no systemic bioavailability)
Legal status
Prescription only (Rx)
Chemical Name
IncobotulinumtoxinA
Elimination half-life
Estimated 18-24 hours
Dosage (Strength)
50 units, 100 units per vial (injection)
Pregnancy
Consult a doctor
Brands
Xeomin
Protein binding
N/A (acts locally at neuromuscular junctions)
PubChem CID
117048383
MedlinePlus
a611011
ChEBI
CHEBI:133087
ATC code
M03AX01
DrugBank
DB00083
KEGG
D00959
Routes of administration
Intramuscular, intradermal injection
Directions
Xeomin may be given intramuscularly or intraglandular by a healthcare professional.
If you have any questions or concerns, talk to your or your child’s healthcare provider.
Ingredients
The active ingredient in Xeomin is incobotulinumtoxinA.
Inactive ingredients include human albumin and sucrose.
Contraindications
Patients who have an infection at the injection sites or who are allergic to botulinum neurotoxin type A or to any of the excipients in Xeomin should not receive it.
Cautions
- Xeomin contains the following FDA Boxed Warning:
- Xeomin’s effects, as well as all botulinum toxin product’s effects, can spread from the injection site to produce symptoms that are consistent with botulinum toxin effects. These symptoms may occur hours to weeks after receiving the injection. Trouble swallowing and breathing can be life threatening; death can also occur. Children treated for spasticity seem to be at greatest risk; however, adults may also experience symptoms, especially those with underlying conditions that would make them more susceptible to these symptoms.
- Before you or your child begins receiving Xeomin injections, talk to the healthcare provider about:
- All the prescription and over-the-counter medications you or your child takes
- Your or your child’s allergies
- Your or your child’s current health problems and past medical history
- Your or your child’s pregnancy or breastfeeding status
- Xeomin contains the following warnings and precautions:
- Trouble breathing, speaking, or swallowing
- Corneal exposure and ulceration
- Risk of ptosis, or drooping of the upper eyelid
- Xeomin’s potency units are not interchangeable with other botulinum toxin products
Side Effects
- Xeomin contains the following FDA Boxed Warning:
- Xeomin’s effects, as well as all botulinum toxin product’s effects, can spread from the injection site to produce symptoms that are consistent with botulinum toxin effects. These symptoms may occur hours to weeks after receiving the injection. Trouble swallowing and breathing can be life threatening; death can also occur. Children treated for spasticity seem to be at greatest risk; however, adults may also experience symptoms, especially those with underlying conditions that would make them more susceptible to these symptoms.
- Before you or your child begins receiving Xeomin injections, talk to the healthcare provider about:
- All the prescription and over-the-counter medications you or your child takes
- Your or your child’s allergies
- Your or your child’s current health problems and past medical history
- Your or your child’s pregnancy or breastfeeding status
- Xeomin contains the following warnings and precautions:
- Trouble breathing, speaking, or swallowing
- Corneal exposure and ulceration
- Risk of ptosis, or drooping of the upper eyelid
- Xeomin’s potency units are not interchangeable with other botulinum toxin products
Side Effects
The most common Xeomin side effects in patients receiving the injections for treating or improving:
- Chronic sialorrhea in adults: tooth extraction, dry mouth, diarrhea, and high blood pressure
- Chronic sialorrhea in pediatric patients: bronchitis, headache, nausea, and vomiting
- Upper limb spasticity in adults: seizure, nasopharyngitis, dry mouth, and upper respiratory tract infection
- Upper limb spasticity in pediatric patients: bronchitis and nasopharyngitis
- Cervical dystonia: trouble swallowing, neck pain, muscle weakness, pain at the injection site, musculoskeletal pain
- Blepharospasm: eyelid drooping, dry eye, vision problems, and dry mouth
- Frown lines between the eyebrows: headache
Immediately notify the health care provider of any side effects that bother you or your child or they persist.
Ask your or your child’s healthcare provider about Xeomin.
Reference
Xeomin. Raleigh, NC and Franksville, WI: Merz Pharmaceuticals, LLC and Merz North America, Inc.; 2023.
Popular Questions
The active ingredient in the injection is incobotulinumtoxinA, which is a form of Botulinum toxin type A. This component works by blocking nerve activity in the muscles, causing a temporary reduction in muscle activity, which can be beneficial for treating specific medical conditions.
Before receiving the injection, inform your doctor if you have conditions such as ALS, myasthenia gravis, Lambert-Eaton syndrome, breathing disorders, trouble swallowing, facial muscle weakness, seizures, bleeding problems, heart disease, diabetes, or if you have had or will have surgery. This information helps the healthcare provider assess risks and customize the treatment plan to avoid complications.
Yes, Xeomin needs to be reconstituted before use. It comes in a powdered form and must be mixed with a specific amount of sterile, preservative-free saline to prepare it for injection. This process is necessary to ensure the correct dosage and effectiveness of the treatment. For further consultation, you can contact us at our toll-free number, 1-800-891-0844, or chat with us online. We are available 24 hours a day, 7 days a week.
The active ingredient in the injection is incobotulinumtoxinA, which is a form of Botulinum toxin type A. This component works by blocking nerve activity in the muscles, causing a temporary reduction in muscle activity, which can be beneficial for treating specific medical conditions.
The injection is used to treat cervical dystonia, which causes abnormal head position and neck pain, and blepharospasm, an abnormal contraction or twitch of the eyelid, in adults who have previously been treated with onabotulinumtoxinA (Botox). These treatments can improve quality of life by reducing painful symptoms and involuntary muscle contractions.
The injection should be administered only by a trained medical professional. This ensures the safety and effectiveness of the treatment by minimizing the risk of side effects and ensuring proper dosage and technique.
Yes, the effects of the injection can spread to areas beyond the injection site, which can cause serious life-threatening side effects. This is important to consider as it underscores the need for administration by a qualified healthcare provider and careful monitoring after the injection.
The effects of the injection are temporary, with symptoms potentially returning completely within 3 months after an injection. This temporary effect is valuable for managing symptoms without committing to permanent changes, allowing adjustments in treatment as needed.
If you experience side effects such as a hoarse voice, drooping eyelids, vision problems, severe muscle weakness, loss of bladder control, or trouble breathing, talking, or swallowing, you should call your doctor immediately. Recognizing these symptoms and seeking prompt medical attention can prevent further complications and ensure your safety.
View allIndividuals who are allergic to botulinum toxin, or have an infection, swelling, or muscle weakness in the area where the injection will be administered, should avoid receiving the injection. This is crucial for preventing adverse reactions and ensuring the treatment's safety.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11676
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