What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Capoten (Captopril)
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Product Details
Description
Capoten (captopril) is a medication used to treat high blood pressure, left ventricular dysfunction after a heart attack, and diabetic neuropathy. It's also used with other medications to treat congestive heart failure.
Fact Table
Formula
C9H15NO3S
License
US FDA
Bioavailability
70–75%
Legal status
Rx-Only
Chemical Name
Captopril
Elimination half-life
1.9 hours
Dosage (Strength)
12.5mg, 25mg, 50mg
Pregnancy
Not Recommended
Brands
Capoten
Protein binding
30%
PubChem CID
44093
MedlinePlus
a682823
ChEBI
3380
ATC code
C09AA01
DrugBank
DB14596
KEGG
DB01197
Routes of administration
By mouth
Directions
Carefully read and follow the instructions that come with your Capoten prescription. Ask your doctor or pharmacist any questions you may have.
Capoten is available in 12.5 mg, 25 mg, 50 mg, and 100 mg tablets.
The typical starting dose for high blood pressure is 25 mg by mouth two or three times a day, one hour before meals. The dose may be adjusted based on response to the medication.
The typical starting dose for heart failure is 25 mg by mouth three times a day. The dose may be adjusted based on blood pressure, salt/volume status, and response to the medication.
The typical starting dose for left ventricular dysfunction after a heart attack is a single 6.25 mg dose by mouth, then 12.5 mg by mouth three times a day. The dosage should be increased to the recommended maintenance dose of 50 mg by mouth three times a day as tolerated.
The recommended dose for diabetic neuropathy is 25 mg by mouth three times a day. The dose may be adjusted in patients with kidney problems.
Ingredients
The active ingredient in Capoten is captopril, an angiotensin I-converting enzyme (ACE) inhibitor. Inactive ingredients include microcrystalline cellulose, corn starch, lactose, and stearic acid.
Contraindications
Do not take Capoten if you are allergic to captopril or other ACE-inhibitors or to any of the other ingredients contained in Capoten.
Cautions
WARNING: FETAL TOXICITY
When pregnancy is detected, discontinue Capoten as soon as possible.
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
- Before you start treatment with Capoten, talk to your doctor about all the medications you take, your allergies, your medical history, your health conditions, and your pregnancy or breastfeeding status.
- Capoten can cause angioedema (swelling under the skin) of the extremities, face, lips, mucous membranes, tongue, glottis, or larynx which can be life threatening. Seek emergency care right away if you experience any of these effects.
- Capoten can cause intestinal angioedema, which causes stomach pain with or without nausea or vomiting.
- Capoten can cause anaphylactoid reactions in patients undergoing desensitizing treatment with hymenoptera venom or with exposure to membranes.
- Capoten can cause low neutrophil count, a type of white blood cell, which can lead to infections.
- Capoten can cause kidney impairment in some patients.
- Capoten can cause proteinuria, the presence of protein in the urine, particularly in patients with previous kidney disease or those who received more than 150 mg a day of Capoten.
- Capoten can cause low blood pressure. Monitor your blood pressure regularly.
- Capoten can cause liver failure, although it's rare. Seek emergency care right away if you develop yellowing of your skin or whites of your eyes, weakness, abdominal pain, or nausea.
- Capoten can cause increased potassium levels. You may be at risk if you have kidney problems, diabetes, or if you take potassium-sparing diuretics or medications or supplements that contain potassium.
- Capoten can cause a dry cough in some patients.
- Patients with aortic stenosis might be at risk of decreased coronary perfusion when treated with Capoten.
- Low blood pressure may occur during surgery or anesthesia in patients taking Capoten.
Side Effects
Capoten medication side effects include rash, low blood pressure, rapid heart rate, chest pain, heart palpitations, altered taste, angioedema, cough, lack of energy, breast tissue enlargement in males, cardiac arrest, cerebrovascular accident/insufficiency, rhythm abnormalities, fainting, skin reactions, pancreatitis, glossitis, indigestion, anemia, liver problems, low sodium levels, muscle pain or weakness, coordination problems, confusion, depression, nervousness, drowsiness, rhinitis, bronchospasm, eosinophilic pneumonitis, blurred vision, and inability to achieve an erection.
These are not all the side effects that can occur when treated with Capoten. Contact your doctor right away if you have side effects that bother you or won't go away.
Reference:
Capoten (Captopril Tablets, USP). Spring Valley, NY: Par Pharmaceutical Companies, Inc.; 2012.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2443
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