What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Synthroid (Levothyroxine)
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Product Details
Description
Synthroid (Levothyroxine) is a medication used to treat hypothyroidism. Hypothyroidism occurs when there is too little thyroid hormone in the body, which can cause a variety of symptoms that impact mood, weight, and body temperature.
The body may have too little thyroid for several reasons, including problems with the thyroid gland itself, problems with the pituitary gland -- which send functional signals to the thyroid gland, differences in genetics (congenital), or acquisition with age.
Synthroid is a synthetic version of the thyroid hormone T4. The generic name is levothyroxine. Synthroid replaces T4 and is converted to active thyroid hormone, T3, in the body.
Directions
Synthroid dosages can range from 12.5 to 200 micrograms daily. Some people may require doses above this range.
Synthroid should be taken on an empty stomach, at least 30 minutes before a meal. Synthroid can be taken with water. Take Synthroid in the same manner each day, since food can timing can change how much is absorbed and impact the treatment.
Ingredients
The active ingredient in Synthroid is levothyroxine sodium.
Fact Table
Formula
C15H11I4NO4
License
EU EMA
Bioavailability
40-80%
Legal status
RX Only
Chemical Name
Levothyroxine
Elimination half-life
7 days in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days
Dosage (Strength)
0.025mg, 0.050mg, 0.075mg, 0.88mg, 0.100mg, 0.112mg, 0.125mg, 0.137mg, 0.150mg, 0.175mg, 0.200mg, 0.300mg (90 tablets)
Pregnancy
Consult a doctor
Brands
Synthroid, Levoxyl, Unithroid, Levothroid
Protein binding
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PubChem CID
5819
MedlinePlus
a682461
ChEBI
18332
ATC code
H03AA01
DrugBank
DB00451
KEGG
D08125
Routes of administration
By mouth
Cautions
Use Synthroid with caution in older adults with underlying cardiovascular disease.
Synthroid requires regular lab monitoring to be effective. Following recommendations from your doctor regarding dose changes and lab monitoring.
Synthroid and other replacement thyroid hormone medications may impact blood glucose control in diabetic patients.
Excess thyroid hormone can decrease bone mineral density, so the lowest effective dose should be used.
Side Effects
If you experience adverse reactions while taking Synthroid, it may be a sign that the dose is too high or too low. Speak with your doctor about any side effects. Common side effects of Synthroid medication include:
- Abdominal cramps
- Anxiety
- Arrhythmias
- Diarrhea
- Dyspnea
- Emotional lability
- Excessive sweating
- Fatigue
- Fever
- Flushing
- Hair loss
- Headache
- Heart failure
- Heat intolerance
- Increased appetite
- Increased pulse and blood pressure
- Insomnia
- Irritability
- Menstrual irregularities
- Nervousness
- Palpitations
- Tachycardia
- Weight loss
References
- Synthroid [package insert]. North Chicago, IL: AbbVie, 2018.
- Jonklaas J, Bianco AC, Bauer AJ, et al. “Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement.” Thyroid. 2014;24(12):1670-1751. doi:10.1089/thy.2014.0028
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1602
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