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What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Natacyn (Natamycin) Opthalmic Suspension
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Generic Equivalent - Natacyn (Natamycin) Opthalmic Suspension
Prescription Required
Strength
Qty
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Related Products & Conditions
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Product Details
Description
Natacyn® (natamycin ophthalmic suspension) 5% is a sterile medication used topically in the eye to treat fungal infections. Each milliliter contains 50 mg of natamycin, an antifungal agent effective against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. The suspension also includes benzalkonium chloride 0.02% as a preservative, with sodium hydroxide and/or hydrochloric acid to adjust the pH, and purified water as inactive ingredients. Natamycin functions by binding to sterols in the fungal cell membrane, altering its permeability and leading to the depletion of essential cellular components, thereby exerting a fungicidal effect.
Fact Table
Formula
C33H47NO13
License
US FDA
Bioavailability
Minimal (topical ophthalmic use)
Legal status
Rx-only (prescription)
Chemical Name
Natamycin
Elimination half-life
Not systemically absorbed
Dosage (Strength)
5% (50 mg/mL) ophthalmic suspension
Pregnancy
Category C – Consult a doctor
Brands
Natacyn
Protein binding
Not applicable (topical)
PubChem CID
5284447
MedlinePlus
a607058
ChEBI
7515
ATC code
S01AA30
DrugBank
DB00826
KEGG
D08226
Routes of administration
Topical (ophthalmic)
Directions
Shake the bottle well before use. For fungal keratitis, instill one drop of Natacyn into the conjunctival sac of the affected eye at hourly or two-hourly intervals. After the initial 3 to 4 days, the frequency can typically be reduced to one drop 6 to 8 times daily. Treatment should continue for 14 to 21 days or until the infection resolves. In cases of fungal blepharitis and conjunctivitis, an initial dosage of 4 to 6 daily applications may suffice. Always follow the specific instructions provided by your healthcare provider.
Ingredients
Active ingredient:
- Natamycin 5% (50 mg/mL)
Inactive ingredients:
- Benzalkonium chloride 0.02% (preservative)
- Sodium hydroxide and/or hydrochloric acid (to adjust pH)
- Purified water
Contraindications
Natacyn is contraindicated in individuals with a known hypersensitivity to natamycin or any of the components of the formulation.
Cautions
Topical Use Only: Natacyn is intended for topical ophthalmic use and should not be injected.Contact Lens Wearers: Patients exhibiting signs and symptoms of fungal eye infections should refrain from wearing contact lenses during treatment.
Pregnancy and Nursing: Natacyn should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administering to nursing mothers, as it is unknown whether natamycin is excreted in human milk.
Pediatric Use: The safety and effectiveness of Natacyn in pediatric patients have not been established.
General Precautions: If there is no improvement in keratitis after 7 to 10 days of treatment, re-evaluation is necessary to determine if the infection is caused by a non-susceptible organism.
Side Effects
The following adverse reactions have been reported during post-marketing use of Natacyn:
- Common: Eye irritation or discomfort.
- Serious: Allergic reactions, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.
If you experience any of these side effects, contact your healthcare provider promptly.
Popular Questions
The active ingredient, natamycin, is present at a concentration of 5% (50 mg/mL) in the suspension. This concentration is specifically designed to effectively treat fungal infections in the eye, providing a targeted antifungal action.
The inactive ingredients include benzalkonium chloride 0.02% as a preservative, sodium hydroxide and/or hydrochloric acid to adjust pH, and purified water. These components help maintain the stability and safety of the suspension, ensuring its efficacy during treatment.
The product is administered topically as an ophthalmic suspension, meaning it is applied directly to the eye. This method allows the medication to directly target fungal infections, ensuring effective treatment at the site of infection.
The bioavailability is minimal since it is used topically for ophthalmic purposes. This ensures that the medication works locally in the eye without significant systemic absorption, reducing the risk of systemic side effects.
Common side effects include eye irritation or discomfort. Awareness of these potential side effects allows users to monitor their symptoms and seek guidance from their healthcare provider if needed.
Serious side effects can include allergic reactions such as rash, itching/swelling, severe dizziness, and trouble breathing. Recognizing these symptoms is crucial for seeking immediate medical attention to prevent complications.
Contact lens wearers should refrain from using their lenses while exhibiting signs and symptoms of fungal eye infections during treatment. This precaution helps prevent further irritation or exacerbation of the infection.
For fungal keratitis, one drop should be instilled into the conjunctival sac of the affected eye at hourly or two-hourly intervals initially. After 3 to 4 days, the frequency can usually be reduced to one drop 6 to 8 times daily. This regimen ensures that the infection is effectively managed and resolved.
Related products include Diflucan (Fluconazole), Ertaczo (Sertaconazole Nitrate), Jublia (Efinaconazole), and Noxafil (Posaconazole). These products may also be useful in treating fungal infections, depending on the specific type and location of the infection.
View allThe ATC code is S01AA30. This classification helps healthcare providers identify and categorize the medication based on its therapeutic use, ensuring appropriate prescription practices.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9739
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