Prescription Required
October 13, 2022 by Alice K. (Texas, United States)
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Medically Reviewed
Please be aware that all information shared here at Canada Pharmacy has been medically reviewed and fact-checked for accuracy. These verifications are made by board-certified medical professionals who have the authority required to state that information related to medical conditions, symptoms, procedures and tests, and standard treatment protocols is valid and truthful. This is based on current guidelines and consensuses shared amongst medical professionals, and in representation of the latest research.
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zoloft (Sertraline)
Also Known as Lustral, Daxid
Strength
Qty
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Related Products & Conditions
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Product Details
Description
Zoloft is a prescription medication used to treat the following conditions:
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Post-traumatic stress disorder (PTSD)
- Social anxiety disorder (SAD)
- Premenstrual dysphoric disorder (PMDD)
The Zoloft generic is sertraline.Zoloft belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs).
Zoloft is available in oral tablets of 25 mg, 50 mg, and 100 mg strengths. It also comes in an oral solution containing 20 mg of sertraline per 1 milliliter.
Fact Table
Formula
C17H17Cl2N
License
US FDA
Bioavailability
44%
Legal status
US: RX Only
Chemical Name
Sertraline
Elimination half-life
23–26 hours (66 hours in less-active metabolite, norsertraline)
Dosage (Strength)
25mg (100 tablets), 50mg (28 or 84 tablets), 100mg (84 tablets)
Pregnancy
Consult a doctor
Brands
Zoloft
Protein binding
98.5%
PubChem CID
68617
MedlinePlus
a697048
ChEBI
9123
ATC code
N06AB06
DrugBank
DB01104
KEGG
D02360
Routes of administration
Topical
Directions
Take Zoloft as prescribed by your doctor. If you have any questions or concerns, talk to your doctor or pharmacist.
The dosage of Zoloft depends on age and the condition being treated:
Adults
- MDD, OCD: The recommended starting dose is 50 mg by mouth per day. Patients may take up to 200 mg per day for maintenance therapy.
- PD, PTSD, SAD: The recommended starting dose is 25 mg by mouth per day. Patients may take up to 200 mg per day for maintenance therapy.
- PMDD continuous dosing: The recommended starting dose is 50 mg by mouth per day. Patients may take up to 150 mg by mouth per day for maintenance therapy.
- PMDD intermittent dosing: The recommended starting dose is 50 mg by mouth per day during the luteal phase. Patients may take up to 100 mg per day during the luteal phase.
Pediatrics
- OCD in pediatric patients between the ages of 6 and 12: The recommended starting dose is 25 mg by mouth per day. Patients may take up to 200 mg per day for maintenance therapy.
- OCD in pediatric patients between the ages of 13 and 17: The recommended starting dose is 50 mg by mouth per day. Patients may take up to 200 mg per day for maintenance therapy.
Ingredients
The active ingredient in Zoloft is sertraline.
Zoloft tablets also contain inactive ingredients including dibasic calcium phosphate dihydrate, D and C Yellow #10 aluminum lake (in 25 mg tablet), FD and C Blue #1 aluminum lake (in 25 mg tablet), FD and C Red #40 aluminum lake (in 25 mg tablet), FD and C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide.
Zoloft oral solution contains inactive ingredients including glycerin, alcohol (12%), menthol, and butylated hydroxytoluene (BHT). The dispenser is made of dry natural rubber.
Contraindications
Some patients should not take Zoloft, including those who take monoamine oxidase inhibitors (MAOIs) or have taken an MAOI within the past 14 days. Patients who take pimozide or are allergic to sertraline or its excipients should also avoid the medication.
Patients should avoid the oral solution if they are taking disulfiram.
Cautions
Zoloft (sertraline) contains an FDA Boxed Warning regarding an increased risk of suicidal thoughts and behaviors. Patients and their friends, family, or caregivers should monitor the patient for signs of suicidal thoughts and behaviors.
- Before you begin treatment with Zoloft, tell your doctor about:
- All the medications you take, including prescription and nonprescription medications, herbals, and supplements.
- Your allergies.
- Your health history and current medical problems.
- Your pregnancy or breastfeeding status.
- The risk of serotonin syndrome is increased when taking SSRIs alone or with other medications that can cause serotonin syndrome such as triptans and serotonin norepinephrine reuptake inhibitors (SNRIs). Ask your doctor if you are unsure whether or not you take any of these medications.
- The risk of bleeding is increased when taking Zoloft with medications that can lead to bleeding such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen or ibuprofen, and warfarin.
- Zoloft may cause a mixed/manic episode in patients with bipolar disorder.
- Patients who have seizures should use caution when taking Zoloft.
- Patients who have untreated narrow angles should not take Zoloft as angle-closure glaucoma can occur.
- Patients who are at risk for QTc prolongation should use Zoloft with caution.
- Zoloft may cause sexual dysfunction including ejaculation problems, decreased desire for sex, and erectile dysfunction.
Side Effects
Common Zoloft side effects include nausea, diarrhea, tremor, indigestion, decreased appetite, excessive sweating, ejaculation failure, and decreased desire for sex; however, these are not all the side effects that can occur with Zoloft use. If you experience bothersome or persistent side effects, contact your doctor right away.
Reference:
Zoloft (sertraline hydrochloride). New York, NY: Roerig; 2021.
Popular Questions
Zoloft, also known by its generic name sertraline, is an antidepressant that belongs to the selective serotonin reuptake inhibitor (SSRI) class. It works by increasing the levels of serotonin in the brain, which can help improve mood, reduce anxiety, and alleviate symptoms of depression. It is commonly prescribed for conditions such as depression, anxiety disorders, and obsessive-compulsive disorder (OCD).
In the US, Zoloft is available by prescription only (RX Only). This ensures that the medication is used under medical supervision, which is important for patient safety.
The elimination half-life of Zoloft is between 23–26 hours, and 66 hours for its less-active metabolite, norsertraline. This information is crucial for understanding how long the drug stays in the body, impacting dosing schedules and the timing of side effects.
The PubChem CID for Zoloft is 68617. This identifier is useful for researchers looking up detailed chemical information in scientific databases.
The KEGG ID for Zoloft is D02360. KEGG provides comprehensive data on the biological functions and interactions of drugs.
The oral solution of Zoloft contains 20 mg of sertraline per 1 milliliter. This form provides flexibility for patients who have difficulty swallowing tablets.
Zoloft tablets contain inactive ingredients such as dibasic calcium phosphate dihydrate, various FD&C color lakes, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide. These ingredients help in the formulation and stability of the tablets.
Sertraline, an SSRI antidepressant, can cause several side effects including nausea, insomnia, sexual dysfunction, and dry mouth. In some cases, it may also lead to increased anxiety, weight gain, and rare but serious side effects like serotonin syndrome or increased suicidal thoughts, especially in young adults and adolescents.
Sertraline is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class, commonly prescribed to treat depression, anxiety disorders, and PTSD. It was first approved by the FDA in 1991 and is known for its relatively favorable side effect profile compared to older antidepressants. Additionally, sertraline is also used off-label for conditions like premature xxxx and social anxiety disorder.
View allThe MedlinePlus reference number for Zoloft is a697048. This reference provides access to detailed consumer health information about the drug.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1925
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Product Reviews
5Out of 5.0
Overall Rating100%of customers that
buy this product give
it a 4 or 5-Star rating.September 12, 2022 by Jean B. (South Carolina, United States)“The ordering process went smoothly. Delivery was a bit longer than expected, but would order from here again. Customer service and follow up was great.”October 17, 2019 by John B. (PA, United States)“The generic version works just as well as the brand name.”July 15, 2019 by John B. (PA, United States)“The value & service in Canada far exceeds the same in the US”April 11, 2019 by Mari L. (GA, United States)“Great deal!”March 14, 2019 by A. G. (VA, United States)“I hate having too take this medication but at least I can find it here while not having insurance.”November 16, 2018 by Judith Q. (PR, United States)“Good”September 27, 2018 by Mari L. (GA, United States)“Very happy with my purchase! 1/10th the cost I pay in the US.”
