Prescription Required
March 11, 2021 by Robin T. (North Carolina, United States)
“I couldn’t afford to use this medication without Canada Pharmacy pricing”
Medically Reviewed
Please be aware that all information shared here at Canada Pharmacy has been medically reviewed and fact-checked for accuracy. These verifications are made by board-certified medical professionals who have the authority required to state that information related to medical conditions, symptoms, procedures and tests, and standard treatment protocols is valid and truthful. This is based on current guidelines and consensuses shared amongst medical professionals, and in representation of the latest research.
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Premarin Cream (Conjugated Estrogens)
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Product Details
Description
PREMARIN cream (conjugated estrogens) is a medication prescribed to treat atrophic vaginitis (thinning, drying, and inflammation of the vaginal walls) and kraurosis vulvae (shrinkage of the skin of the vagina and vulva). PREMARIN cream may also be prescribed to treat dyspareunia (pain or difficulty during intercourse).
After menopause, the levels of circulating estrogen decreases. Additionally, different types of estrogens are present than pre-menopause. PREMARIN works by increasing levels of the levels of certain estrogens and decreasing circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Increasing levels of estrogen help to maintain secondary sexual characteristics.
Directions
When treating atrophic vaginitis or kraurosis vulvae, the typical dosage of PREMARIN is 0.5 g once daily intravaginally for 7 days on and 21 days off. Use the included applicator to measure the appropriate dose.
When treating dyspareunia, the typical dose is 0.5 g twice weekly.
Ingredients
The active ingredients in PREMARIN cream are conjugated estrogens - sodium estrone sulfate, sodium equilin sulfate, 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin.
The inactive ingredients include benzyl alcohol, cetyl alcohol, cetyl esters wax, glycerin, glyceryl monostearate, mineral oil, methyl stearate, and white wax.
Fact Table
Formula
C22H19N3O4
License
US FDA
Bioavailability
Varies
Legal status
US: RX Only
Chemical Name
Conjugated Estrogens
Elimination half-life
Estrone: 26.7 hours, Estrone (BA): 14.8 hours, Equilin: 11.4 hours
Dosage (Strength)
0.625mg/g x 14 grams (1/3 tubes), 0.625mg/g x 30 grams (1 tube)
Pregnancy
Consult a doctor
Brands
Premarin Cream
Protein binding
High
PubChem CID
656613
MedlinePlus
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ChEBI
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ATC code
G03CA57
DrugBank
DB00286
KEGG
D04070
Routes of administration
Topical
Cautions
Estrogens have been shown to increase the risk of stroke and deep vein thrombosis (DVT) in postmenopausal women. The increased risk has been shown with daily oral estrogen supplements, and the risk is probably lower for topical formulations.
Daily oral estrogens have also been shown to increase the risk of myocardial infarction (heart attack), invasive breast cancer, pulmonary emboli, and uterine cancer. This risk is probably not as great for topical formulations.
Due to the increased risk of the above-listed health conditions, PREMARIN cream should be used for the shortest amount of time at the lowest possible dose.
Speak to your doctor for a full list of cautions before using PREMARIN cream.
Side Effects
The most common side effects of PREMARIN cream include:
- Abdominal pain
- Back pain
- Mastalgia
- Pain
- Vaginitis
- Vasodilation
- Weakness
Speak with your doctor for a full list of possible side effects. Systemic side effects may also occur.Premarin Cream (Conjugated Estrogens) Frequently Asked Questions
Click the links below to jump to the section of the FAQ you want to learn more about.
- How does Premarin Cream Work?
- Can Personal Lubricants Be Used in Place of Premarin Cream?
- How Often Should I Apply Premarin Cream?
- How Long Will Tube of Premarin Conjugated Estrogens Cream Last?
- How Long Until I Experience Results from Using Premarin Cream?
- Is Premarin Cream Available in a Generic?
- Is Premarin Cream Suitable for All Women?
- What are Common Premarin Cream Side Effects?
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How does Premarin Cream Work?
Hormonal levels for certain hormones drop as a woman becomes menopausal. Vaginal atrophy and dyspareunia occur because the lack of sufficient levels for one those hormones – estrogen – promotes less natural lubrication of the vaginal walls as the body no longer foresees the possibility of a pregnancy. Vaginal walls become thinner over time too. Premarin provides a mixture of estrogen hormones to replenish those levels and promote better lubrication so that a woman is able to enjoy intimacy with her partner.
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Can Personal Lubricants Be Used in Place of Premarin Cream?
The can be used for temporary relief from painful sex during menopause, but using a prescription menopause treatment medication like Premarin is a better choice for women who find sex painful during menopause. Providing conjugated estrogens provides more long-term dyspareunia relief and treatment for vaginal dryness, something which can continue for women after they’ve finished menopause. Women may also find that their symptoms are more severe periodically.
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How Often Should I Apply Premarin Cream?
The dosage frequency for Premarin Cream will be indicated in your prescription and based on your doctor’s recommendation depending on the severity of these menopause symptoms. Treatment objectives will also determine how often to apply Premarin:
For dyspareunia or painful sex treatment:
Apply 2x per week or in a cyclic regimen of 21 days of therapy with 0.5mg dose followed by 7 days off therapy and not applying the cream until the next week begins to start the 28-day cycle again. This will be explained in your prescription
For vaginal atrophy treatment (VVA):
Apply in a cyclic regimen of 21 days of therapy (starting at 0.5mg dose with dosage adjustments made on level of effectiveness and response according to doctor and prescription) followed by 7 days off therapy and not applying the cream until the next week begins to start the 28-day cycle again. This will be explained in your prescription.
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How Long Will Tube of Premarin Conjugated Estrogens Cream Last?
As with all medicated creams, dosage strength and frequency of application will determine how long one tube of the medication will last for the user. Using standard Premarin cream dosage and treatment regimen most women will find one tube of Premarin Cream lasts them around 6 months. You can discuss this with your dispensing pharmacist if you would like to know more.
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How Long Until I Experience Results from Using Premarin Cream?
Most women will begin to see results from using Premarin Cream and less vaginal dryness or pain during sex at around the 12 week (3 month) point from beginning treatment. It is important to take your medication exactly as directed and consistently in order to have these expectations.
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Is Premarin Cream Available in a Generic?
Premarin Cream is not available in a generic equivalent at this time, but a generic conjugated estrogens cream may be available in the future. You can order Premarin Cream online from Canada Pharmacy and pay less for branded Premarin and likely pay significantly less than you would at your local pharmacy.
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Is Premarin Cream Suitable for All Women?
No, it is not. Women who have a history of unusual vaginal bleeding, cancer, heart attack or stroke, or blood clots will not be suitable for using Premarin cream. Women who have or at risk of gallbladder disease or who are taking thyroid medication may also not be suitable for this medication. All of this will be determined based on your doctor’s professional opinion.
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What are Common Premarin Cream Side Effects?
Common Premarin Cream side effects include headache, pelvic or breast pain, vaginitis or vaginal bleeding. Most women only have mild side effects if any when using Premarin for menopause symptoms relief.
References
- Premarin [package insert].Philadelphia, PA: Wyeth Pharmaceuticals Inc, 2008.
Popular Questions
The most common side effects of PREMARIN (conjugated estrogens) include headaches, breast pain or tenderness, irregular xxxx bleeding or spotting, and stomach or abdominal cramps. Other side effects can include nausea, vomiting, and bloating. It's important to discuss any side effects with a healthcare provider.
The bioavailability of Premarin Cream varies. Bioavailability refers to the degree and rate at which the active ingredients are absorbed into the bloodstream, which is essential for the effectiveness of the medication.
The dosage strength of Premarin Cream is 0.625mg/g. This specific concentration is effective in treating symptoms of menopause like atrophic vaginitis and dyspareunia.
One tube of Premarin Cream contains 30 grams. This quantity is sufficient for a prescribed treatment period, ensuring you have enough medication for your therapy.
PREMARIN estrogen cream is used to treat symptoms of menopause such as xxxx dryness, itching, and burning. It works by replacing estrogen, a hormone that the body stops producing in sufficient quantities during menopause, thereby alleviating these discomforts. For further consultation, you can contact us at our toll-free number, 1-800-891-0844, or chat with us online. We are available 24 hours a day, 7 days a week.
The width of the Premarin Cream tube is not specified in the provided details, but it's designed to be user-friendly for comfortable application. This helps in easy storage and handling.
The length of the Premarin Cream tube is not specified in the provided details, but it's typically long enough to ensure precise dosing. This is valuable for accurate and effective treatment.
The depth of the Premarin Cream tube is not specified in the provided details, but it's designed to be compact and easy to squeeze. This makes the application process straightforward and efficient.
The active ingredients in Premarin Cream are conjugated estrogens, including sodium estrone sulfate, sodium equilin sulfate, 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. These components work together to alleviate menopausal symptoms by replenishing estrogen levels.
View allThe inactive ingredients include benzyl alcohol, cetyl alcohol, cetyl esters wax, glycerin, glyceryl monostearate, mineral oil, methyl stearate, and white wax. These ingredients help in maintaining the cream's consistency and stability, ensuring effective application and absorption.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1734
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Product Reviews
4.6Out of 5.0
Overall Rating93%of customers that
buy this product give
it a 4 or 5-Star rating.February 19, 2020 by Andrea L. (Idaho, United States)“Best price anywhere. Easy process.
Don’t bother trying anywhere else.”February 10, 2020 by Mary L. (South Carolina, United States)“Good option to buying estradiol”January 14, 2020 by Altha S. (Missouri, United States)“I could not afford this cream in the States. I order it from Canada pharmacy and it is a safe and effective prescription. I could not be happier.”January 9, 2020 by Barbara A. (Florida, United States)“Very satisfied”December 21, 2019 by Nama (MT, United States)“*”September 8, 2019 by Shirley S. (MI, United States)“Good value”September 3, 2019 by BARBARA A. (FL, United States)“I HAVE USED THIS PRODUCT FOR MANY YEARS AND WOULD HIGHLY RECOMMEND IT.”July 12, 2019 by Nancy B. (OR, United States)“Not only good medication, but excellent cost and delivery sooner then 3-5 weeks.”June 7, 2019 by Altha S. (MO, United States)“The Premarin cream I use from Canada pharmacy is an outstanding product at over half the price where I live in the U S. Easy to order and arrived in about 8 days. I order other medications from Canada Pharmacy as well with the same quality results. I will continue to use Canada Pharmacy for medications I could not afford here and I’m grateful to Canada Pharmacy for their quality service staff.”
