What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Evotaz (Atazanavir / Cobicistat)
Prescription Required
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Product Details
Description
For people with Acquired Immunodeficiency Syndrome (AIDS), the disease is chronic and life-changing. A doctor may prescribe Evotaz to prevent further development of AIDS and progression of symptoms.
AIDS is caused by Human Immunodeficiency Virus (HIV-1), which is currently incurable. However, medications like Evotaz prevent the replication of viral particles, slowing the infection.
Fact Table
Formula
Atazanavir: C38H52N6O7 Cobicistat: C40H53N7O5S2
License
US DailyMed
Bioavailability
60-68%
Legal status
Rx-Only
Chemical Name
Atazanavir / Cobicistat
Elimination half-life
Atazanavir: Approximately 7 hours Cobicistat: Approximately 3-4 hours
Dosage (Strength)
300mg / 150mg
Pregnancy
Consult Doctor
Brands
Evotaz
Protein binding
Atazanavir: Approximately 86% Cobicistat: 97-98%
PubChem CID
Atazanavir: 148192 Cobicistat: 25151513
MedlinePlus
a614043
ChEBI
37924
ATC code
J05AR15
DrugBank
Atazanavir: DB01072 Cobicistat: DB09065
KEGG
Atazanavir: D01276 Cobicistat: D09881
Routes of administration
Oral
Directions
The dosage of Evotaz is one tablet by mouth once daily. Do not change your dosage without speaking to your doctor.
Ingredients
Evotaz has two active ingredients: atazanavir 300 mg and cobicistat 150 mg.
Atazanavir blocks a critical protein in HIV viral particles and prevents it from replicating. Cobicistat "boosts" the amount of atazanavir in the bloodstream by slowing its metabolism.
Interactions
Many drug interactions exist with Evotaz. Do not start any new medications without telling the doctor that prescribed Atazanavir. Common interactions include:
- Alfuzosin
- Alprazopam
- Aprepitant
- Avanafil
- Bosutinib
- Budesonide
- Buprenorphine
- Carbamazepine
- Cisapride
- Conivaptan
- Dapoxetine
- Domperidone
- Dronedarone
- Elbasvir and Grazoprevir
- Eplerenone
- Ergot Derivatives
- Everolimus
- Fluticasone
- Fosaprepitant
- Fusidic Acid
- Ibrutinib
- Irinotecan Products
- Ivabradine
- Lurasidone
- Midazolam
- Ombitasvir, Paritaprevir, and Ritonavir
- Paclitaxel
- Phenobarbital
- Pimozide
- Primidone
- Ranolazine
- Regorafenib
- Repaglinide
- Rifampin
- Ritonavir
- Rivaroxaban
- Salmeterol
- Saquinavir
- Simeprevir
- Simvastatin
- St John's Wort
- Suvorexant
- Tamsulosin
- Ticagrelor
- Triazolam
- Vincristine
Cautions
Evotaz can cause the redistribution of fat tissue. Tell your healthcare provider if you experience this symptom.
Use caution if you have a history of kidney or liver problems.
Use caution if you have a history of bleeding disorders or diabetes.
Side Effects
Tell your doctor and pharmacist if you experience any of the following Evotaz side effects:
- Abnormal dreams
- Decreased neutrophils
- Depression
- Diarrhea
- Dyslipidemia
- Fanconi syndrome
- Fatigue
- Glycosuria
- Headache
- Hematuria
- Increased bilirubin
- Increased creatinine phosphokinase
- Increased gamma-glutamyl transferase
- Increased serum glucose
- Insomnia
- Jaundice
- Nausea
- Renal disease
- Skin rash
- Upper abdominal pain
- Vomiting
References
- Evotaz [package insert]. Princeton, NJ: Bristol-Myers Squibb; 2020.
Frequently Asked Questions about Evotaz (Atazanavir / Cobicistat)
What is Evotaz (Atazanavir / Cobicistat)?
Evotaz is a prescription medication that combines two active ingredients, Atazanavir and Cobicistat. It is used to treat HIV (human immunodeficiency virus) infection in combination with other antiretroviral drugs.
How does Evotaz work to treat HIV?
Evotaz works by inhibiting the replication of the HIV virus in the body. Atazanavir is a protease inhibitor that blocks an enzyme needed by HIV to multiply, while Cobicistat enhances the effectiveness of Atazanavir.
What is the recommended dosage of Evotaz?
The dosage of Evotaz may vary depending on your individual medical condition and other medications you are taking. It is essential to follow your healthcare provider's instructions and take Evotaz as prescribed.
Can I take Evotaz with other medications?
It is crucial to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, supplements, and herbal products. Some medications may interact with Evotaz, and your doctor can determine the safest treatment regimen for you.
Are there any potential side effects of Evotaz?
Like all medications, Evotaz may cause side effects. Common side effects can include nausea, diarrhea, headache, and jaundice (yellowing of the skin or eyes). If you experience severe or unusual side effects, contact your healthcare provider.
Is Evotaz a cure for HIV?
No, Evotaz is not a cure for HIV. It is part of a combination therapy used to manage HIV infection and slow down the progression of the disease. HIV remains a chronic condition, and lifelong treatment is usually required.
Can I drink alcohol while taking Evotaz?
It is generally recommended to limit or avoid alcohol consumption while taking Evotaz, as alcohol can interact with the medication and may increase the risk of side effects or liver problems.
What should I do if I miss a dose of Evotaz?
If you miss a dose of Evotaz, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Is it safe to use Evotaz during pregnancy or while breastfeeding?
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Evotaz with your healthcare provider. They can assess the potential risks and benefits and provide guidance on the best course of action.
How often should I get tested for HIV while taking Evotaz?
Your healthcare provider will determine the appropriate schedule for HIV testing while taking Evotaz. Regular monitoring of your viral load and CD4 cell count is essential to assess the effectiveness of the treatment.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13223
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