Actemra (Tocilizumab)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details


    Actemra (tocilizumab) is a medication used to treat rheumatoid arthritis, giant cell arteritis, systemic sclerosis-associated interstitial lung disease, polyarticular juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, cytokine release syndrome, and COVID-19.

    Actemra is available as a subcutaneous injection and an intravenous (IV) infusion.

    Fact Table




    US DailyMed, US FDA, EU EMA


    Tocilizumab is administered by injection and does not have a specific bioavailability value since it acts systemically

    Legal status


    Chemical Name


    Elimination half-life

    8–14 days during steady state (dependent on concentration)

    Dosage (Strength)

    Typically ranging from 162 mg to 324 mg


    Consult Doctor


    Actemra is the primary brand name for tocilizumab

    Protein binding

    Tocilizumab does not significantly bind to plasma proteins

    PubChem CID

    Not available




    The ChEBI (Chemical Entities of Biological Interest) entry for tocilizumab is not available as it is a protein-based drug

    ATC code






    Routes of administration

    Actemra is administered by intravenous infusion or subcutaneous injection


    Use Actemra exactly as your doctor has directed. If you have any questions or concerns, talk to your doctor or pharmacist.

    Actemra Dosing:

    Your dose will depend on the condition being treated and your weight. Your doctor will also determine whether you should receive subcutaneous injections or an IV infusion.

    Your doctor will advise you on how to use Actemra, how much you should use, and how often you should use it.


    The active ingredient in Actemra is tocilizumab.

    Inactive ingredients in the subcutaneous injection include L-arginine hydrochloride, L-histidine, L-histidine hydrochloride monohydrate, L-methionine, polysorbate 80, and water for Injection.

    Inactive ingredients in the IV formulation includedisodium phosphate dodecahydrate/sodium dihydrogen phosphate dihydrate buffered solution, polysorbate 80, sucrose, and water for Injection.


    Actemra should not be administered to patients who are allergic to the medication.


    Actemra has the following FDA Boxed Warnings:

    • Serious infections that can lead to hospitalization or cause death, including tuberculosis (TB), bacterial, invasive fungal, viral, and other opportunistic infections, have occurred in patients who received Actemra.
    • If a serious infection occurs, Actemra should be stopped until the infection is managed.
    • Testing for latent TB should be conducted except in patients with COVID-19. TB treatment should be initiated before starting Actemra if the test result is positive.
    • All patients should be monitored for TB during treatment, regardless of a negative latent TB test.
    • Before you begin treatment with Actemra, tell your doctor:
      • About all medications you take, including prescription and nonprescription medications
      • About your allergies
      • About your current health conditions and past medical history
      • If you are pregnant or breastfeeding
    • Gastrointestinal perforation can occur with Actemra treatment. Patients who are at increased risk should use Actemra with caution.
    • Actemra can cause liver damage. Patients should seek medical care right away if they develop fatigue, weight loss, abdominal pain, dark urine, or yellowing of the skin or whites of the eyes.
    • Because Actemra can cause changes in neutrophil count, platelet count, lipid count, and liver function tests, monitoring of these labs is recommended.
    • Actemra can cause hypersensitivity reactions, including anaphylaxis and even death.
    • Live vaccines should not be administered to patients receiving Actemra.

    Side Effects

    The most common Actemra side effects include upper respiratory tract infections, nasopharyngitis, headache, high blood pressure, increased liver function tests, and injection site reactions.

    You can buy Actemra online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.


    Actemra. South San Francisco, CA: Genentech Inc.; 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 12266

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