Description
ACULAR LS (ketorolac tromethamine) is an ophthalmic medication used after different types of eye surgery.
ACULAR LS belongs to the medication class non-steroidal anti-inflammatory (NSAID). NSAIDs like ACULAR LS reduce pain, inflammation, swelling, and redness where they are applied. Ketorolac works by blocking the enzymes cyclooxygenase 1 and cyclooxygenase 2. Blocking these enzymes prevents cells of the immune system from activating.
ACULAR LS is used after the following surgeries: cataract extraction, corneal refractive surgery, and cataract surgery. It can also be used to treat ocular itching that occurs with seasonal allergies.
Directions
Instill one drop to the affected eye(s) four times daily or as directed by your doctor. Sometimes ACULAR LS is applied only twice daily.
Do not touch the tip of the dropper directly onto the eye. Contact with the eye can cause contamination by viruses or bacteria, which can lead to eye infections.
Remove contact lenses before applying and wait at least 10 minutes before putting them back in.
Ingredients
The active ingredient in ACULAR LS is ketorolac tromethamine 0.4%.
The name for ACULAR LS generic is also ketorolac tromethamine.
Interactions
Since eye medications are not absorbed into the bloodstream, they do not have drug interactions with most other medications.
However, when using other eye drops, separate their administration by at least five minutes.
Fact Table |
Formula |
C15H13NO3 |
License |
AU, EU EMA, US FDA |
Bioavailability |
80-100% (oral) 100% IV/IM |
Legal status |
RX Only |
Chemical Name |
Ketorolac |
Elimination half-life |
3.5 h to 9.2 h, Young adults;4.7 h to 8.6 h, Elderly (mean age 72) |
Dosage (Strength) |
LS 0.4% (5mL) |
Pregnancy |
Consult a doctor |
Brands |
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik |
Protein binding |
99% |
PubChem CID |
3826 |
MedlinePlus |
a693001 |
ChEBI |
6129 |
ATC code |
M01AB15, S01BC05 |
DrugBank |
DB00465 |
KEGG |
D08104 |
Routes of administration |
By mouth, under the tongue, intramuscular, intravenous, eye drops, nasal spray |
Cautions
Long-term use can lead to adverse effects on the cornea, including erosion, perforation, ulceration, and keratitis. Do not use this medication for longer than instructed by your doctor.
Tell your doctor if you have a known allergy to NSAIDs.
Side Effects
The most common side effects that can happen while using ACULAR LS include
- Allergic reactions
- Conjunctival hyperemia
- Corneal edema
- Corneal infiltrates
- Headache
- Irritation
- Ocular edema
- Ocular inflammation
- Ocular pain
- Transient stinging and burning
References
Acular LS [package insert].Palo Alto, CA: Allergan; 2003.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 9283