What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Alecensa (Alectinib)
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Product Details
Description
What is Aldactazide?
- Aldactazide (Spironolactone/Hydrochlorothiazide) is a combination medication used to treat high blood pressure, congestive heart failure, and cirrhosis of the liver.
How does it work?
- The medications contained in Aldactazide are diuretics that work in a complementary way. Spironolactone blocks the activity of aldosterone in your kidneys to increase your urine output. Hydrochlorothiazide promotes the excretion of sodium and water by preventing your kidneys from re-absorbing them.
How is it supplied?
- You can buy Aldactazide online at Canada Pharmacy in brand or generic form.
- Brand name Aldactazide
- 25mg/25mg tablets
- Generic Spironolactone/Hydrochlorothiazide
- 25mg/25mg tablets
- 50mg/50mg tablets
- Brand name Aldactazide
How should I store it?
- Store your Aldactazide at room temperature and keep it out of reach of children.
Fact Table
Formula
C30H34N4O2
License
US: FDA
Bioavailability
37%
Legal status
Rx Only
Chemical Name
Alectinib
Elimination half-life
33 hours
Dosage (Strength)
150 mg
Pregnancy
Not yet classified
Brands
Alecensa
Protein binding
greater than 99%
PubChem CID
49806720
MedlinePlus
a616007
ChEBI
90936
ATC code
L01XE36
DrugBank
DB11363
KEGG
D10542
Routes of administration
By mouth
Directions
Should I take Alecensa with food?
- You should take your dose with a meal or snack.
Are there any special instructions?
- Do not open your Alecensa capsules. You should swallow them whole.
- If you miss a dose or vomit after taking a capsule, skip it, and continue with your next scheduled dose.
What is the usual dose?
- Take 600mg by mouth twice daily.
- Your doctor could reduce your dose if you experience adverse effects.
Ingredients
What is the active ingredient in Alecensa?
- The active ingredient is alectinib hydrochloride.
What are the inactive ingredients?
- See the package insert for a full list of inactive ingredients.
Cautions
Who should avoid taking Alecensa?
- Do not use Alecensa if you have a known allergy to any of the ingredients.
- Alecensa should not be used in pregnancy.
- Female patients should avoid pregnancy during treatment and for one week after discontinuation. Visit our birth control page for more information.
- Male patients should use contraception during therapy and for three months after discontinuation.
What are the risks?
- Tell your doctor if you experience any of the following adverse effects. They could reduce your dose, interrupt your therapy, or discontinue your treatment.
- Symptomatic bradycardia
- Slowed heart rate (less than 60 beats per minute)
- Low blood pressure
- Chest discomfort
- Lightheadedness
- Shortness of breath
- Muscle pains
- Difficulty breathing
- Cough
- Fever
- Symptomatic bradycardia
- Alecensa treatment can cause an increase in liver enzymes. Your doctor should periodically monitor your liver.
- Alecensa treatment can cause your kidney function to decrease. Your doctor should monitor your kidney function.
Side Effects
What are the common Alecensa side effects?
- Edema
- Constipation
- Low-grade anemia
- Low-grade lymphocytopenia
- Liver enzyme elevation
- Hyperbilirubinemia
- Muscle pain
- Difficulty breathing
- Fatigue
What are the serious Alecensa side effects?
- Bradyarrhythmia (see irregular heartbeat page)
- Endocarditis
- Intestinal perforation
- High-grade anemia
- Bleeding
- High-grade lymphocytopenia
- Increased creatinine kinase
- Kidney impairment
- Interstitial lung disease
- Pneumonia
- Pneumonitis
- Pulmonary embolism
References:
- DailyMed - ALECENSA- alectinib hydrochloride capsule. (2019). Retrieved April 07, 2020
- Alecensa. (n.d.). Retrieved April 07, 2020, from
- Corte, C. M., Viscardi, G., Liello, R. D., Fasano, M., Martinelli, E., Troiani, T., . . . Morgillo, F. (2018). Role and targeting of anaplastic lymphoma kinase in cancer. Molecular Cancer, 17(1). doi:10.1186/s12943-018-0776-2
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13263
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