What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Lopidine Eye Drops (Apraclonidine)


Lopidine Eye Drops (Apraclonidine)

Prescription Required


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  • Product Details


    IOPIDINE (apraclonidine) is a prescription medication for use in the eye. IOPIDINE can be prescribed to treat open-angle glaucoma or to prevent an increase in intraocular pressure after surgery.

    In open-angle glaucoma, the drainage canals in the eye become clogged, which increases the fluid pressure in the eye. If left untreated, glaucoma can lead to damage of the optic nerve and blindness.

    Fact Table




    US FDA



    Legal status


    Chemical Name


    Elimination half-life

    8 hours

    Dosage (Strength)



    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    Topical (ophthalmic solution)


    For open-angle glaucoma, Instill 1 to 2 drops into the affected eye(s) three times daily as directed by the prescriber.

    Do not touch the tip of the applicator to the surface of the eye. Doing so can contaminate the medication, leading to infections of the eye.

    Wait 15 minutes after applying IOPIDINE to insert contact lenses.


    The active ingredient in IOPIDINE is apraclonidine hydrochloride. 

    Inactive ingredients include benzalkonium chloride, hydrochloric acid, purified water, sodium acetate, sodium chloride, and sodium hydroxide.


    IOPIDINE is unlikely to interact with other medications because most of it will not be absorbed into the bloodstream. However, some may enter circulation, and caution should be used if you are taking any of the following:

    • Alcohol
    • Anti-diabetic agents
    • Antihypertensives
    • Barbituates
    • Beta-blockers
    • Digoxin
    • Monoamine Oxidase Inhibitors (MAOIs)
    • Sedatives
    • Tricyclic antidepressants


    Tell your healthcare provider if you have a history of kidney impairment or a history of liver impairment.

    Use caution if you have a history of cardiovascular disease or cerebrovascular disease.

    Side Effects

    The most common apraclonidine side effects may include:

    • Blanching
    • Blurred vision
    • Conjunctivitis
    • Discharge
    • Discomfort
    • Dry eye
    • Dry mouth
    • Eyelid edema
    • Foreign body sensation
    • Hyperemia
    • Pruritus
    • Tearing


    1. Iopidine [package insert].Fort Worth, Texas: Alcon Laboratories; 2016.

    Frequently Asked Questions about Lopidine Eye Drops

    What are Lopidine Eye Drops used for?

    Lopidine Eye Drops are typically used to treat certain eye conditions, such as glaucoma or ocular hypertension, by reducing intraocular pressure.

    How should I use Lopidine Eye Drops?

    Always use Lopidine Eye Drops as prescribed by your doctor. Generally, you should tilt your head back, pull down your lower eyelid, and instill the prescribed number of drops into the affected eye.

    How often should I use the eye drops?

    The frequency of use will depend on your doctor's prescription. Always follow the recommended dosage and schedule.

    What should I do if I miss a dose?

    If you miss a dose, use it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

    Can I wear contact lenses while using Lopidine Eye Drops?

    Some formulations may not be suitable for use with contact lenses. Remove your lenses before applying the drops and wait at least 15 minutes before reinserting them.

    Are there any side effects?

    Some common side effects include redness, itching, dryness, or a temporary burning sensation in the eyes. If you experience severe or persistent side effects, contact your doctor immediately.

    Can I use Lopidine Eye Drops with other medications?

    Inform your doctor about all medications you are currently taking, including other eye drops, to ensure there are no interactions.

    Is it safe to use Lopidine Eye Drops during pregnancy or while breastfeeding?

    Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using Lopidine Eye Drops.

    How should I store Lopidine Eye Drops?

    Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13269

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