Description
Aptiom is a prescription drug for the treatment of partial-onset seizures. Partial-onset seizures are abnormal electrical activity where the signals are not transmitted correctly in the brain. As opposed to other types of seizures, partial-onset only occurs in one part of the brain. Typically a person does not lose consciousness with this type of seizure.
Fact Table |
Formula |
C17H16N2O3 |
License |
EU EMA, AU |
Bioavailability |
High bioavailability and reaches peak serum concentration 1-4 hours after a given dose |
Legal status |
RX Only |
Chemical Name |
Eslicarbazepine Acetate |
Elimination half-life |
10-20 hours |
Dosage (Strength) |
200mg (30 tablets), 400mg (30 tablets), 600mg (60 tablets) |
Pregnancy |
Consult a doctor |
Brands |
Aptiom |
Protein binding |
~30% |
PubChem CID |
179344 |
MedlinePlus |
- |
ChEBI |
87016 |
ATC code |
N03AF04 |
DrugBank |
DB09119 |
KEGG |
D09612 |
Routes of administration |
Oral |
Directions
The starting dosage is 400 mg by mouth once daily. This may be increased to 800 mg once daily after one week or 1200 mg once daily after two weeks.
Ingredients
The active ingredient in Aptiom is eslicarbazepine acetate.
Interactions
Common drug-drug interactions may include:
- Abemaciclib
- Antihepaciviral Combination Products
- Asunaprevir
- Avacopan
- Avanafil
- Avapritinib
- Axitinib
- Bedaquiline
- Bosutinib
- Capmatinib
- Cariprazine
- Cobimetinib
- Daridorexant
- Dasabuvir
- Deflazacort
- DOXOrubicin
- Elbasvir and Grazoprevir
- Encorafenib
- Entrectinib
- Fedratinib
- Fexinidazole
- Finerenone
- Flibanserin
- Ibrexafungerp
- Infigratinib
- Ivabradine
- Lemborexant
- Lonafarnib
- Lumateperone
- Lurbinectedin
- Mavacamten
- Mobocertinib
- Neratinib
- Nisoldipine
- Olaparib
- Olutasidenib
- Orelabrutinib
- Oxcarbazepine
- Pacritinib
- Pemigatinib
- Pimavanserin
- Pretomanid
- Ranolazine
- Rimegepant
- Selpercatinib
- Selumetinib
- Simeprevir
- Sonidegib
- Tazemetostat
- Ulipristal
- Velpatasvir
- Venetoclax
- Voclosporin
- Vonoprazan
- Vorapaxar
- Voxilaprevir
- Zanubrutinib
Cautions
Tell your doctor if you have suicidal thoughts while starting this drug.
Tell your doctor if you experience any skin reactions while starting this medication.
Ask your doctor or pharmacist for a full list of precautions.
Side Effects
The most common side effects may include the following:
- Abdominal pain
- Abnormal gait
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Ataxia
- Blurred vision
- Cognitive dysfunction
- Constipation
- Cough
- Decreased hematocrit
- Decreased hemoglobin
- Decreased T3 level
- Decreased T4
- Decreased visual acuity
- Depression
- Diarrhea
- Diplopia
- Dizziness
- DRESS syndrome
- Drowsiness
- Dysarthria
- Equilibrium disturbance
- Falling
- Fatigue
- Gastritis
- Headache
- Hypercholesterolemia
- Hypertension
- Hypochloremia
- Hyponatremia
- Increased creatine phosphokinase
- Increased LDL cholesterol
- Increased serum bilirubin
- Increased serum transaminases
- Increased serum triglycerides
- Insomnia
- Leukopenia
- Megaloblastic anemia
- Memory impairment
- Nausea
- Nystagmus
- Pancytopenia
- Peripheral edema
- Prolongation P-R interval on ECG
- Severe dermatological reaction
- SIADH
- Skin rash
- Stevens-Johnson syndrome
- Thrombocytopenia
- Toxic epidermal necrolysis
- Tremor
- Urinary tract infection
- Vertigo
- Vomiting
- Weakness
References
Aptiom [package insert]. Marlborough, MA: Sunovion Pharmaceuticals Inc.; 2013.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13260