Description
Austedo (deutetrabenazine) is a prescription medicine approved to help manage involuntary movements associated with Huntington’s disease and tardive dyskinesia. By regulating dopamine activity in the brain, Austedo reduces the severity of uncontrolled body movements, allowing patients to improve daily functioning and quality of life. Austedo uses include the treatment of both conditions with proven clinical benefits and a safety profile supported by ongoing research.
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Fact Table
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Formula
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C19H21D6NO3
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License
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US DailyMed
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Bioavailability
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less than 10%
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Legal status
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Prescription Required
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Chemical Name
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Deutetrabenazine
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Elimination half-life
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9–10 hours
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Dosage (Strength)
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6mg, 9mg, 12mg
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Pregnancy
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Consult a doctor - safety in human pregnancy is unknown
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Brands
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Austedo
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Protein binding
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60–65% bound to plasma proteins
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PubChem CID
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73437646
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MedlinePlus
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a617022
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ChEBI
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Unknown
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ATC code
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N07XX16
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DrugBank
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DB12161
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KEGG
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D10701
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Routes of administration
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Oral (by mouth)
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Directions
Austedo dosing must be tailored to each patient’s needs and medical history. Treatment typically begins with a low dose that is gradually adjusted by a healthcare provider. The tablets should be taken with food to improve absorption. It is important to follow your doctor’s exact instructions, as doses may vary depending on whether the medication is prescribed for Huntington’s chorea or tardive dyskinesia. Do not alter your dose or stop taking Austedo without consulting your physician.
Ingredients
The active ingredient in Austedo is deutetrabenazine. Each tablet also contains inactive ingredients such as lactose monohydrate, microcrystalline cellulose, magnesium stearate, and film-coating materials that support stability and absorption. These components work together to ensure the medicine is effective and well tolerated.
Interactions
Austedo can interact with certain medications, including monoamine oxidase inhibitors (MAOIs), reserpine, strong CYP2D6 inhibitors, and alcohol. Patients should provide their healthcare provider with a full list of prescriptions, over-the-counter drugs, and supplements to minimize the risk of interactions. Combining Austedo with other medicines that affect serotonin or dopamine levels may increase the chance of side effects.
Cautions
Before starting Austedo, patients should inform their doctor of any history of depression, suicidal thoughts, liver disease, or heart rhythm problems. This medication may not be suitable for individuals with untreated depression or suicidal risk. Regular monitoring is recommended during treatment. Because Austedo may cause drowsiness, patients should avoid driving or operating machinery until they understand how the medication affects them. Pregnant or breastfeeding women should consult their physician before use.
Side Effects
Like all prescription medicines, Austedo side effects can occur. Common side effects include sleepiness, diarrhea, dry mouth, and fatigue. Some patients may also experience restlessness or changes in mood. Serious side effects, such as worsening depression or suicidal thoughts, are rare but require immediate medical attention. Discuss any side effects with your doctor to determine the best course of action.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 15439
Prescription Required
