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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Auvelity (Dextromethorphan/Buproprion)

Brand

Auvelity (Dextromethorphan/Buproprion)

Prescription Required

Strength
Qty
45mg / 105mg

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  • Product Details

    Description

    Auvelity (dextromethorphan/bupropion) is a prescription oral medication approved for the treatment of major depressive disorder in adults. It is the first and only fast-acting oral NMDA receptor antagonist combined with bupropion to help restore chemical balance in the brain. Patients using Auvelity may notice improvements in mood, energy, and focus, making it an important option for those who need effective relief from depression. Auvelity medication is designed to work differently than standard antidepressants, giving patients and doctors a new choice in managing symptoms.

    Fact Table

    Formula

    C18H25NO (Dextromethorphan), C13H18ClNO (Bupropion)

    License

    US FDA (2022)

    Bioavailability

    Dextromethorphan: 11%; Bupropion: Unknown

    Legal status

    Prescription only (Rx)

    Chemical Name

    Dextromethorphan and Bupropion

    Elimination half-life

    Dextromethorphan: 2–4 hours; Bupropion: 21 hours (parent), 29–37 hours (active metabolite)

    Dosage (Strength)

    45 mg dextromethorphan / 105 mg bupropion ER tablet

    Pregnancy

    Consult a doctor; Bupropion is Pregnancy Category C

    Brands

    Auvelity

    Protein binding

    Dextromethorphan: Unknown; Bupropion: 84%

    PubChem CID

    Dextromethorphan: 5360696; Bupropion: 444

    MedlinePlus

    a622019

    ChEBI

    Dextromethorphan: 4470; Bupropion: 3219

    ATC code

    N06AX62

    DrugBank

    Dextromethorphan: DB00514; Bupropion: DB01156

    KEGG

    Dextromethorphan: D07710; Bupropion: D07541

    Routes of administration

    Oral

    Directions

    The recommended starting dose is one tablet taken by mouth once daily in the morning for three days, then increased to one tablet twice daily. Tablets should be swallowed whole and not cut, crushed, or chewed. Auvelity should be taken exactly as prescribed by your healthcare provider, and doses should not be missed or doubled. Do not stop taking Auvelity suddenly without medical guidance, as this can affect treatment outcomes.

    Ingredients

    Each Auvelity tablet contains two active ingredients: dextromethorphan hydrobromide and bupropion hydrochloride. The formulation also includes inactive components such as excipients, stabilizers, and coating materials to ensure effectiveness, stability, and safe absorption.

    Interactions

    Auvelity can interact with monoamine oxidase inhibitors (MAOIs), other antidepressants, antipsychotics, strong CYP2D6 inhibitors, alcohol, and drugs that lower seizure threshold. Combining Auvelity with certain medications that influence serotonin or dopamine may increase the risk of adverse reactions. Patients should provide their healthcare provider with a complete list of prescriptions, over-the-counter products, and supplements before beginning treatment.

    Cautions

    Auvelity is not suitable for everyone. Patients with a history of seizures, eating disorders, bipolar disorder, or those who have recently stopped alcohol or sedatives should discuss risks with their doctor. It may cause dizziness, insomnia, or increases in blood pressure. Patients should avoid operating heavy machinery until they know how the medication affects them. Auvelity cost may vary depending on prescription coverage, but Canada Pharmacy provides safe and affordable access. Pregnant and breastfeeding women should consult a healthcare provider before starting this medication.

    Side Effects

    Common Auvelity side effects include dizziness, dry mouth, constipation, sleep disturbances, fatigue, and increased sweating. Less common but more serious side effects may involve high blood pressure, mood changes, or an increased risk of suicidal thoughts in young adults. Patients should report any concerning or severe side effects to their healthcare provider promptly.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 15441

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