Bambevi (Bevacizumab)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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Prescription Required

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    Your oncologist may prescribe Bambevi for the treatment of various types of cancers, including metastatic colorectal cancer (mCRC), metastatic lung cancer, recurrent platinum-resistant ovarian cancer, or recurrent glioblastoma. It is a non-chemotherapy drug that belongs to the class of medications called biologics.1

    Bambeviu is a monoclonal IgG1 antibody that binds to vascular endothelial growth factor (VEGF). VEGF is a protein on the surface of endothelial cells that increases the growth of new blood vessels. By binding to VEGF, Bambevi prevents the growth of new blood vessels that would supply tumors with oxygenated blood.


    The Bambevi dosage is individualized based on the type of cancer and patient characteristics. Take it exactly as directed by your doctor.


    The active ingredient in Bambevi is bevacizumab.


    Common drug-drug interactions may include:

    • Alendronate
    • Bacillus Calmette-Guérin (BCG)
    • Belimumab
    • Carboplatin
    • Clozapine
    • Cyclophosphamide
    • Dipyrone
    • Doxorubicin
    • Etidronate
    • Ibandronate
    • Ifosfamide
    • Risedronate
    • Sorafenib
    • Sunitinib
    • Zoledronic acid


    Use caution if you have a history of cardiovascular disease, gastrointestinal disease, kidney problems, or respiratory disease.

    There are many potential precautions with Bambevi. Ask your doctor for a full list that applies to you.

    Side Effects

    The most common side effects are:

    • Abdominal pain
    • Allergic reactions
    • Bleeding
    • Blood clots
    • Bronchitis
    • Bruising
    • Changes in moods
    • Changes in the sense of taste
    • Chest pain
    • Chills
    • Coughing
    • Diarrhea
    • Difficulty in sleeping
    • Excessive tearing
    • Fever
    • Headache
    • High blood pressure
    • Hoarseness
    • Infections
    • Joint pain
    • Loss of appetite
    • Lung infection
    • Mouth infection
    • Muscle pain
    • Nausea
    • Necrotizing fasciitis
    • Nephrotic syndrome
    • Nose infection
    • Pain
    • Pelvic pain
    • Protein in the urine
    • Rectal bleeding
    • Runny nose
    • Scaling skin or changes in skin color
    • Seizures
    • Shortness of breath
    • Sinus infection
    • Skin infection
    • Sores in the mouth
    • Stroke
    • Swelling and numbness of the hand and feet
    • Swelling of the hand and feet
    • Throat infection
    • Tingling sensation or numbness in toes and fingers
    • Tiredness
    • Trachea
    • Urine infection
    • Vision loss
    • Vomiting
    • Weight loss


    Bambevi [package insert]. Toronto, Ontario: Apotex; September 2021.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14433

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