What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Bosulif (Bosutinib)
Prescription Required
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Product Details
Description
Your oncologist may prescribe Bosulif if you have chronic, accelerated, or blast-phase Philadelphia-chromosome-positive chronic myelogenous leukemia (CML).
It works by inhibiting the Bcr-Abl kinase that promotes cancerous growth in CML. It also inhibits several other kinases like Scr, Lyn, and Hck, which promote growth in myeloid cell lines.
Fact Table
Formula
C26H29Cl2N5O3
License
US FDA, EMA
Bioavailability
34% (fasted state)
Legal status
Prescription only (?)
Chemical Name
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate
Elimination half-life
22-27 hours
Dosage (Strength)
100 mg, 400 mg, 500 mg tablets
Pregnancy
Not recommended
Brands
Bosulif
Protein binding
94-96%
PubChem CID
5328940
MedlinePlus
a613016
ChEBI
71723
ATC code
L01XE14
DrugBank
DB06616
KEGG
D08874
Routes of administration
Oral
Directions
The starting dosage of Bosulif is 500 mg daily. The usual maintenance dose is 200-600 mg once daily.
Ingredients
The active ingredient in Bosulif is bosutinib.
Interactions
Common drug-drug interactions may include:
- Adagrasib
- Adenovirus Vaccine
- Amprenavir
- Aprepitant
- Asciminib
- Atazanavir
- Avacopan
- Bacillus of Calmette and Guerin Vaccine, Live
- Belzutifan
- Boceprevir
- Carbamazepine
- Ceritinib
- Cholera Vaccine, Live
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clofazimine
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Daridorexant
- Darunavir
- Dengue Tetravalent Vaccine, Live
- Dexlansoprazole
- Diltiazem
- Dronedarone
- Duvelisib
- Enzalutamide
- Erythromycin
- Esomeprazole
- Fedratinib
- Fexinidazole
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosnetupitant
- Fosphenytoin
- Idelalisib
- Imatinib
- Indinavir
- Influenza Virus Vaccine, Live
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lanreotide
- Lansoprazole
- Larotrectinib
- Lefamulin
- Lenacapavir
- Letermovir
- Levoketoconazole
- Lonafarnib
- Lorlatinib
- Lumacaftor
- Mavacamten
- Measles Virus Vaccine, Live
- Mifepristone
- Mitotane
- Mumps Virus Vaccine, Live
- Nefazodone
- Nelfinavir
- Netupitant
- Nilotinib
- Nirogacestat
- Olutasidenib
- Omaveloxolone
- Omeprazole
- Pacritinib
- Pantoprazole
- Phenobarbital
- Phenytoin
- Pirtobrutinib
- Poliovirus Vaccine, Live
- Posaconazole
- Primidone
- Rabeprazole
- Repotrectinib
- Ribociclib
- Rifampin
- Rifapentine
- Ritlecitinib
- Ritonavir
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Saquinavir
- Schisandra sphenanthera
- Smallpox Vaccine
- St John's Wort
- Telaprevir
- Telithromycin
- Tocilizumab
- Trofinetide
- Troleandomycin
- Tucatinib
- Typhoid Vaccine, Live
- Varicella Virus Vaccine, Live
- Verapamil
- Vonoprazan
- Voriconazole
- Voxelotor
- Yellow Fever Vaccine
- Zoster Vaccine, Live
Cautions
Pregnant individuals or those planning to become pregnant should avoid taking this medication.
Patients should inform their healthcare providers about any history of chronic infections, gastrointestinal issues, fluid retention, or liver problems.
Side Effects
The most common side effects of this drug may include:
- Abdominal pain
- Abnormal liver function
- Acute renal failure
- ALT/SGPT level raised
- Angina pectoris
- Anaphylactic shock
- Body fluid retention
- Constipation
- Cough
- Decrease in appetite
- Diarrhea
- Edema of face
- Erythema multiforme
- Fatigue
- Febrile neutropenia
- Gastrointestinal hemorrhage
- Headache
- Heart failure
- Myocardial ischemia
- Nausea
- Pancreatitis
- Peripheral edema
- Pericardial effusion
- Pericarditis
- Pleural effusion
- Prolonged QT interval
- Pulmonary edema
- Pulmonary hypertension
- Rash
- Renal impairment
- Respiratory failure
- Respiratory tract infection
- Right bundle branch block
- Sinus tachycardia
- Stevens-Johnson syndrome
- Tachycardia
- Thrombocytopenia
- Vomiting
References
- Bosulif [package insert]. New York, NY: Pfizer; September 2012.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14574
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