Brenzys (Etanercept)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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Prescription Required

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    Brenzys is a prescription drug used for the treatment of various inflammatory conditions. Common indications include rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.

    Brenzys is a soluble form of the p75 tumor necrosis factor (TNF) receptor administered via injection. Once in the bloodstream, it binds TNF alpha and TNF beta, causing biological TNF to become inactive. By inactivating TNF, Brenzys decreases the inflammatory response.


    The usual dosage is 25-50 mg injected under the skin once or twice weekly. The length of therapy depends on the condition being treated.

    Take Brenzys exactly as instructed by your doctor.


    The active ingredient in Brenzys is etanercept.


    Common drug-drug interactions with this medication may include

    • Abatacept
    • Adenovirus Vaccine
    • Anakinra
    • Anifrolumab-fnia
    • Bacillus of Calmette and Guerin Vaccine, Live
    • Baricitinib
    • Cholera Vaccine, Live
    • Cyclophosphamide
    • Dengue Tetravalent Vaccine, Live
    • Infliximab
    • Influenza Virus Vaccine, Live
    • Measles Virus Vaccine, Live
    • Mumps Virus Vaccine, Live
    • Poliovirus Vaccine, Live
    • Rilonacept
    • Rotavirus Vaccine, Live
    • Rubella Virus Vaccine, Live
    • Smallpox Vaccine
    • Typhoid Vaccine, Live
    • Varicella Virus Vaccine, Live
    • Vedolizumab
    • Yellow Fever Vaccine
    • Zoster Vaccine, Live


    Your doctor should test for tuberculosis (TB) before starting treatment.

    All age-appropriate vaccinations should be completed before starting this drug.

    Tell your doctor if you have a history of liver, kidney, heart, or neurologic disease before starting this drug.

    Taking Brenzys can decrease the immune response and significantly increase the risk of infection.

    Side Effects

    Common side effects may include

    • Aplastic anemia
    • Autoimmune hepatitis
    • Cancer
    • Congestive heart failure
    • Demyelinating disease of the central nervous system
    • Erythema multiforme
    • Hepatosplenic T-cell lymphoma
    • Hypersensitivity reaction
    • Infectious disease
    • Injection site disorder
    • Leukemia
    • Malignant lymphoma
    • Melanoma
    • Multiple sclerosis
    • Necrotizing fasciitis
    • Optic neuritis
    • Pancytopenia
    • Peripheral demyelinating neuropathy
    • Primary cutaneous vasculitis
    • Reactivation of hepatitis B viral hepatitis
    • Seizure
    • Skin cancer
    • Squamous cell carcinoma of skin
    • Stevens-Johnson syndrome
    • Toxic epidermal necrolysis
    • Transverse myelitis, acute
    • Tuberculosis
    • Upper respiratory infection


    Brenzys [package insert]. Kirkland, QC, Canada: Merck; August 2016.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14434

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