What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Brilinta (Ticagrelor)
Also Known as Brilique
Prescription Required
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Product Details
Description
Brilinta (ticagrelor) is available by prescription only to decrease the risk of the following conditions:
- cardiovascular death, heart attack, and stroke in patients with acute coronary syndrome (ACS) or a history of a heart attack.
- stent thrombosis, or occlusion, in ACS patients.
- a first heart attack or stroke in patients who have coronary artery disease (CAD) and are at high risk of these events.
- stroke in patients who have acute ischemic stroke or high-risk transient ischemic attack (TIA).
Brilinta is available in 60 mg and 90 mg oral tablets.
Fact Table
Formula
C23H28F2N6O4S
License
FDA approved
Bioavailability
36% (Ticagrelor), 88% (active metabolite)
Legal status
Prescription drug
Chemical Name
Ticagrelor
Elimination half-life
7 hours (Ticagrelor), 8.5 hours (active metabolite)
Dosage (Strength)
Tablets; 60 mg, 90 mg
Pregnancy advice
Consult a doctor - Category C (US)
Brands
Brilinta, Possia
Protein binding
>99.7%
PubChem CID
9871419
MedlinePlus
a611050
ChEBI
68558
ATC code
B01AC24
DrugBank
DB08816
KEGG
D09017
Routes of administration
Oral
Directions
Follow your doctor's instructions on how to take Brilinta. Tell your doctor or pharmacist about any questions or concerns you may have.
Brilinta dosing depends on the condition being treated and is recommended to be taken with aspirin. Consult with your doctor about how much Brilinta and aspirin is right for you.
Ingredients
The active ingredient in Brilinta is ticagrelor.
Inactive ingredients in the 60 mg tablets include mannitol, dibasic calcium phosphate, sodium starch glycolate, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, polyethylene glycol 400, ferric oxide black, and ferric oxide red.
Inactive ingredients in the 90 mg tablets include mannitol, dibasic calcium phosphate, sodium starch glycolate, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, talc, polyethylene glycol 400, and ferric oxide yellow.
Contraindications
Patients who have had bleeding in the brain, active bleeding, or an allergy to ticagrelor or to any of its excipients should not take the medication.
Cautions
Brilinta has an FDA Boxed Warning regarding the risk of significant and potentially fatal bleeding. Brilinta should not be administered to patients with active pathological bleeding or a history of bleeding in the brain. In addition, Brilinta should not be administered to patients undergoing urgent coronary artery bypass graft surgery (CABG). If bleeding occurs, it is recommended to be managed without stopping Brilinta, if possible; stopping Brilinta can increase the risk of cardiovascular events.
Brilinta also has an FDA Boxed Warning against taking 100 mg or more of aspirin with Brilinta, as doing so can decrease Brilinta's effects.
- Before you begin treatment with Brilinta, talk to your doctor about:
- All the prescription and over-the-counter medications you take, including herbals, vitamins, and supplements.
- Your allergies.
- Your current health problems and past medical history.
- If you are pregnant or breastfeeding.
- Shortness of breath may occur with the use of Brilinta.
- Patients should not stop taking Brilinta unless their doctor has instructed them to do so.
- Abnormal slow heart rhythms can occur with the use of Brilinta.
- Patients with severe liver problems should not take Brilinta.
- Central sleep apnea can occur with the use of Brilinta.
- Brilinta can interfere with certain laboratory tests.
Side Effects
Common Brilinta medication side effects include bleeding and shortness of breath; however, these are not all the side effects that can occur. Contact your doctor right away if you have side effects that are bothersome or persistent.
Reference:
Brilinta (ticagrelor). Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12817
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