Description
Brisdelle (paroxetine) is a drug used to treat moderate to severe hot flashes in women with menopause.
Fact Table |
Formula |
C19H20FNO3 |
License |
US FDA, US DailyMed |
Bioavailability |
about 50% |
Legal status |
Rx-Only |
Chemical Name |
Paroxetine |
Elimination half-life |
21 hours |
Dosage (Strength) |
7.5mg |
Pregnancy |
not recommended |
Brands |
Brisdelle |
Protein binding |
93–95% |
PubChem CID |
43815 |
MedlinePlus |
a698032 |
ChEBI |
7936 |
ATC code |
N06AB05 |
DrugBank |
DB00715 |
KEGG |
D02362 |
Routes of administration |
By mouth |
Directions
Brisdelle is available in 7.5 mg capsules.
The recommended dose is 7.5 mg by mouth once daily at bedtime.
Ingredients
The active ingredient in Brisdelle is paroxetine.
Contraindications
Do not take Brisdelle with monoamine oxidase inhibitors or within 14 days of using a monoamine oxidase inhibitor.
Do not take Brisdelle with thioridazine.
Do not take Brisdelle with pimozide.
Do not take Brisdelle if you are allergic to paroxetine or any other ingredient in Brisdelle.
Do not take Brisdelle if you are pregnant.
Cautions
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS
See full prescribing information for complete boxed warning.
- Potential for increased risk of suicidal thinking and behavior
- Monitor for worsening and emergence of suicidal thoughts and behaviors
|
- Before you start taking Brisdelle, tell your doctor:
- About any allergies you have
- About any medications you take, including prescription, over-the-counter, vitamins, and herbal supplements
- About any medical conditions you have
- If you are pregnant or plan to become pregnant
- If you are currently breastfeeding or plan to breastfeed
- Brisdelle can increase the risk of suicidal thinking and behavior. Tell your doctor right away if you experience suicidal thoughts, ideations, or behavioral changes.
- Brisdelle may increase your risk for serotonin syndrome. Seek medical care right away if you experience agitation, restlessness, trouble sleeping, confusion, fast heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle twitching or rigidity, excessive sweating, diarrhea, headache, shivering, or goosebumps.
- Brisdelle can reduce the effects of Tamoxifen.
- Your risk for bleeding increases when taking Brisdelle and non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, or other drugs that increase the risk of bleeding. Watch for signs of bleeding such as nosebleeds, bleeding from your gums, or the presence of blood in your stools.
- Tell your doctor if you have vision problems such as glaucoma.
- Tell your doctor if you have seizures or a condition that can cause seizures.
- Brisdelle can cause low sodium levels in the blood. Seek medical care right away if you experience confusion, nausea, vomiting, energy loss, drowsiness, mood changes, restlessness, muscle weakness, muscle spasms or cramps, or seizures.
- Brisdelle can increase your risk for bone fractures.
- Brisdelle can cause mania or hypomania.
- Brisdelle can cause feelings of restlessness.
- Brisdelle can cause problems with sex.
- Do not drive or operate machinery until you know how Brisdelle affects you.
Side Effects
The most common side effects associated with Brisdelle include headache, fatigue, nausea, and vomiting. Contact your doctor right away if you develop side effects that worsen or won't go away.
References:
- Brisdelle Prescribing Information. Roswell, GA: Sebela Pharmaceuticals, Inc.; 2021.
- Serotonin syndrome. Mayo Clinic. January 22, 2022. Accessed February 4, 2022.
- Hyponatremia. Mayo Clinic. May 23, 2020. Accessed February 4, 2022.
About Dr. Savannah Muncy (Page Author)
Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13596