What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Buccastem (Prochlorperazine)


Buccastem (Prochlorperazine)

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  • Product Details


    BUCCASTEM (prochlorperazine) is a medication prescribed to treat nausea and vomiting associated with migraine. While the generic drug prochlorperazine is available in the United States, this particular formulation is not.

    BUCCASTEM works by blocking dopamine receptors in the brain. Dopamine receptors are involved in regulating several processes in the body, including nausea and vomiting.


    Place 1-2 tablet(s) in the mouth between the lip and gums twice daily for up to two days. Use BUCCASTEM as directed by your physician.

    After placing the tablet, it will soften and stick to the gums. Do not move the tablet around in the mouth as this will cause it to dissolve too quickly. The tablet should dissolve over one to two hours.

    Take BUCCASTEM after meals.


    The active ingredient in BUCCASTEM is prochlorperazine.

    BUCCASTEM 3 mg is equivalent to 1.85 mg of prochlorperazine base.


    BUCCASTEM has drug interactions with the following types of medications:

    • Anticholinergic medications
    • Anticoagulants
    • Antiseizure medications
    • Blood pressure medications
    • Levodopa
    • Lithium 
    • Sedatives

    Tell your doctor if you use any medications in these classes before you start using BUCCASTEM.


    BUCCASTEM may increase your sensitivity to sunlight.

    Use this medication with caution if you have a history of blood clots.

    Use with caution if you are older or at risk of falls, since BUCCASTEM can cause a drop in blood pressure that increases the chances of a fall.

    Side Effects

    The most common BUCCASTEM side effects may include:

    • Agitation
    • Altered taste
    • Changes in blood sugar
    • Convulsions or tremor
    • Dizziness
    • Drowsiness
    • Dry mouth
    • Insomnia
    • Low blood pressure
    • Nausea
    • Numbness of the mouth
    • Restlessness or anxiety
    • Sensitivity to the sun
    • Skin reactions
    • Upper respiratory infection
    • Vomiting


    1. Buccastem [package insert].Hereford, UK: Alliance Pharmaceuticals; 2020

    Fact Table




    AU, US FDA



    Legal status

    RX Only

    Chemical Name


    Elimination half-life

    4-8 hours, differs with the method of administration

    Dosage (Strength)

    3mg (50 tablets)


    Consult a doctor


    Buccastem, Compazine, Compro

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth, rectal, intramuscular (IM), intravenous (IV)

    Frequently Asked Questions about Buccastem

    What is Buccastem?

    Buccastem is a brand name for the medication prochlorperazine. It is primarily used to treat nausea and vomiting, as well as symptoms of schizophrenia and anxiety.

    How does Buccastem work?

    Prochlorperazine, the active ingredient in Buccastem, belongs to a group of medicines called phenothiazines. It works by blocking certain chemical receptors in the brain, particularly dopamine receptors, which helps to reduce symptoms like nausea and vomiting.

    How should I take Buccastem?

    Always take Buccastem as prescribed by your doctor. The tablets are usually placed under the upper lip or inside the cheek, allowing them to dissolve slowly. Do not swallow the tablets whole.

    What are the potential side effects of Buccastem?

    Common side effects include drowsiness, dry mouth, blurred vision, and constipation. Less common side effects can include low blood pressure, skin reactions, and movement disorders. Always consult your doctor if you experience any unusual or severe side effects.

    Can I drink alcohol while taking Buccastem?

    It's advisable to avoid alcohol while taking Buccastem as it can increase the risk of side effects, especially drowsiness.

    Can I take Buccastem during pregnancy?

    Always consult your doctor before taking any medication during pregnancy. Buccastem should only be taken during pregnancy if the benefits outweigh the risks.

    Can I drive or operate machinery after taking Buccastem?

    Buccastem can cause drowsiness and blurred vision. If you experience these side effects, avoid driving or operating heavy machinery.

    How should I store Buccastem?

    Store Buccastem in a cool, dry place, away from direct sunlight and out of reach of children.

    Can I take Buccastem with other medications?

    Some medications can interact with Buccastem. Always inform your doctor of all medications you are taking, including over-the-counter drugs and supplements.

    What should I do if I miss a dose?

    If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13270

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