What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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    Chloroquine malaria treatment is a medication approved to prevent and treat malaria infection. It can also be prescribed to treat extraintestinal amebiasis.

    Chloroquine is an anti-infective agent that works by binding to DNA and RNA polymerase in parasites. By blocking these proteins, chloroquine interferes with normal parasite metabolism. It also concentrates within the acid vesicles of parasites, causing a pH shift that impairs their growth.


    The dosage of chloroquine depends on what is being treated. Take chloroquine exactly as prescribed by your doctor.

    The usual doses are:

    • Prevention of malaria: One Chloroquine 500 mg tablet by mouth once weekly, 1-2 prior to traveling to an area endemic with malaria. Continue weekly dosages for four weeks after leaving the area.
    • Treatment of extraintestinal amebiasis: Two 500 mg (1000 mg total) on days 1-2, followed by 500 mg once daily for 2-3 weeks
    • Treatment of malaria: Two 500 mg (1000 mg total) by mouth on day 1, then 500 mg 6, 24, and 48 hours after the first dose.

    Chloroquine is available in Chloroquine 250 mg and Chloroquine 500 mg.


    The active ingredient in Chloroquine is chloroquine phosphate.


    Significant drug-drug interactions exist with chloroquine. Tell your doctor about any medications you are taking, including:

    • Ampicillin
    • Antacids
    • Cholera vaccine
    • Dapsone
    • Domperidone
    • Kaolin
    • Lanthanum
    • Mefloquine
    • QT-prolonging agents
    • Rabies vaccine
    • Remdesivir


    Tell your doctor if you have a history of kidney, liver, or heart disease.

    Chloroquine can cause severe hypoglycemia (low blood sugar).

    Chloroquine has many precautions. Speak with your doctor before starting this medication.

    Side Effects

    Common side effects may include:

    • Abdominal cramps
    • Blurred vision
    • Changes in hair color
    • Changes in mood
    • Confusion
    • Darkening of skin
    • Depression
    • Diarrhea
    • Easy bruising
    • Hair loss
    • Headache
    • Hearing changes
    • Liver disease
    • Muscle fatigue
    • Nausea
    • Paling of lips or skin
    • Shortness of breath
    • Signs of severe infection
    • Sun sensitivity
    • Swelling
    • Tiredness
    • Unwanted movements
    • Vomiting
    • Weakness
    • Worsening of skin conditions


    Drug [package insert]. Eatontown, NJ: Westward; 2009.

    Frequently Asked Questions about Chloroquine

    What is Chloroquine, and what is it used for?

    Chloroquine is a medication that has been used to treat and prevent malaria for many years. It is also sometimes used to treat certain autoimmune diseases like rheumatoid arthritis and lupus.

    How does Chloroquine work against malaria?

    Chloroquine works by interfering with the growth and reproduction of the malaria parasites in the red blood cells. It prevents the parasites from breaking down hemoglobin, which is essential for their survival.

    Is Chloroquine still effective against malaria?

    Chloroquine resistance has become a significant problem in many parts of the world. It may not be effective in regions where malaria parasites have developed resistance to the drug. It is essential to consult with a healthcare provider or travel medicine specialist for up-to-date malaria prevention recommendations.

    Can Chloroquine be used to prevent COVID-19?

    While Chloroquine and its derivative, hydroxychloroquine, were initially considered as potential treatments for COVID-19, their effectiveness in preventing or treating the disease has not been conclusively proven. These drugs should only be used for COVID-19 under the guidance of a healthcare professional in specific situations.

    What are the common side effects of Chloroquine?

    Common side effects of Chloroquine may include stomach upset, nausea, vomiting, diarrhea, headache, dizziness, and skin itching. More severe side effects are rare but can include heart rhythm disturbances and vision problems.

    Is Chloroquine safe for long-term use in autoimmune diseases?

    Chloroquine can be used for long-term treatment of autoimmune diseases like rheumatoid arthritis and lupus under the supervision of a healthcare provider. Regular monitoring is essential to check for any potential side effects.

    Are there any drug interactions with Chloroquine?

    Chloroquine can interact with other medications, including certain antibiotics, antacids, and drugs that affect heart rhythm. It's crucial to inform your healthcare provider about all the medications you are taking to avoid potential interactions.

    Can Chloroquine be used during pregnancy and breastfeeding?

    The use of Chloroquine during pregnancy and breastfeeding should be discussed with a healthcare provider. In some cases, it may be considered if the potential benefits outweigh the risks.

    Is Chloroquine available over-the-counter, or do I need a prescription?

    In many countries, Chloroquine is available only with a prescription due to the need for proper dosing and monitoring, especially when used for malaria prevention or treatment of autoimmune diseases.

    Can Chloroquine be used as a standalone treatment for autoimmune diseases?

    Chloroquine is often used in combination with other medications to manage autoimmune diseases effectively. Your healthcare provider will determine the best treatment plan for your specific condition.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13283

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