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Clavulin

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Clavulin is a combination antibiotic containing amoxicillin (a penicillin-type antibiotic) and clavulanic acid (a beta-lactamase inhibitor). This formulation broadens the antibacterial spectrum of amoxicillin by inhibiting beta-lactamase enzymes produced by resistant bacteria. Clavulin is indicated for the treatment of various infections caused by susceptible strains of bacteria, including infections of the respiratory tract, urinary tract, skin and soft tissue, and otitis media. It is available in multiple formulations, including tablets, chewable tablets, and oral suspension.

    Fact Table

    Formula

    C16H19N3O5S (Amoxicillin), C8H9NO5 (Clavulanic acid)

    License

    US FDA, EMA, Health Canada

    Bioavailability

    ~95% (Amoxicillin), ~60% (Clavulanic acid)

    Legal status

    Rx-only

    Chemical Name

    Amoxicillin and Clavulanate potassium

    Elimination half-life

    Amoxicillin: ~1.3 hours, Clavulanic acid: ~1 hour

    Dosage (Strength)

    250/125 mg, 500/125 mg, 875/125 mg tablets; 400/57 mg per 5 mL suspension

    Pregnancy

    Generally considered safe (Pregnancy Category B)

    Brands

    Clavulin, Augmentin, Co-amoxiclav

    Protein binding

    Amoxicillin: 17–20%, Clavulanic acid: ~25%

    PubChem CID

    33613 (Amoxicillin), 5280980 (Clavulanic acid)

    MedlinePlus

    a685024

    ChEBI

    2955 (Amoxicillin), 3826 (Clavulanic acid)

    ATC code

    J01CR02

    DrugBank

    DB01060 (Amoxicillin), DB00766 (Clavulanic acid)

    KEGG

    D08341

    Routes of administration

    Oral, Intravenous

    Directions

    Clavulin should be taken orally, typically every 8 or 12 hours depending on the formulation and severity of infection. It should be taken at the start of a meal to enhance absorption and reduce gastrointestinal discomfort. The dosage and duration depend on the patient’s age, weight, renal function, and the type and severity of infection. Prescribers should follow local antimicrobial guidelines when determining treatment duration. Tablets should not be split unless scored and approved for that use.

    Ingredients

    Active Ingredients:

    • Amoxicillin (as amoxicillin trihydrate)
    • Clavulanic acid (as potassium clavulanate)

    Inactive Ingredients vary by formulation but may include:

    • Colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, and flavoring agents (for suspensions and chewables).

    Contraindications

    Clavulin is contraindicated in patients with:

    • A history of hypersensitivity to beta-lactam antibiotics (e.g., penicillins, cephalosporins)
    • A previous history of cholestatic jaundice or hepatic dysfunction associated with clavulanate-containing products

    Cautions

    Use with caution in patients with hepatic impairment, renal dysfunction, or a history of antibiotic-associated colitis. Periodic monitoring of liver, renal, and hematologic function is advised during prolonged therapy. Dosage adjustments may be required in patients with moderate to severe renal impairment. Clavulin should not be used for viral infections. Prolonged use may result in fungal or bacterial superinfection, including Clostridioides difficile-associated diarrhea.

    Side Effects

    Common side effects may include:

    • Diarrhea
    • Nausea
    • Vomiting
    • Skin rash
    • Vaginal yeast infection

    Less common but potentially serious side effects include:

    • Hepatic dysfunction (including hepatitis and cholestatic jaundice)
    • Hypersensitivity reactions (e.g., anaphylaxis, angioedema)
    • Stevens-Johnson syndrome
    • Blood disorders (e.g., thrombocytopenia, anemia)

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 2206

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