Description
Clomicalm (clomipramine hydrochloride) is a tricyclic antidepressant formulated for veterinary use in dogs, primarily indicated for the treatment of separation anxiety in conjunction with a behavior modification program. It is also sometimes used off-label for compulsive disorders and noise phobias. Clomicalm acts by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, helping to stabilize mood and reduce anxiety-related behaviors. It is approved for use in dogs older than 6 months and weighing more than 2.5 kg.
Directions
Clomicalm is administered orally, typically at a starting dose of 1 to 2 mg/kg twice daily, or as prescribed by a veterinarian. The tablets can be given with or without food. It is important to maintain consistency in dosing time and duration. Behavioral improvement is generally observed within the first few weeks of treatment, although optimal results require concurrent behavioral therapy. Do not discontinue abruptly; tapering may be needed to avoid withdrawal symptoms.
Ingredients
Each Clomicalm tablet contains:
- Clomipramine hydrochloride
- Available strengths include:
- 5 mg, 20 mg, 40 mg, and 80 mg tablets
Inactive ingredients may include lactose, starch, and other excipients to aid in tablet formulation and stability.
Contraindications
Clomicalm is contraindicated in dogs with:
- Known hypersensitivity to clomipramine or other tricyclic antidepressants
- Cardiac arrhythmias or existing heart disease
- Concurrent use of monoamine oxidase inhibitors (MAOIs), such as selegiline or amitraz
- History of seizures or seizure disorders
Cautions
Caution should be exercised in dogs with liver or kidney impairment, glaucoma, urinary retention, or gastrointestinal disorders. Periodic veterinary evaluation is recommended during long-term use. Clomicalm may lower the seizure threshold; use with care in predisposed breeds. Avoid combining with other serotonergic medications unless under veterinary supervision, due to the risk of serotonin syndrome. Safety in pregnant or lactating dogs has not been established.
Side Effects
Reported side effects may include:
- Vomiting or reduced appetite
- Constipation or dry mouth
- Rarely, tremors or seizures
- Behavioral disinhibition or paradoxical agitation
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 9670
Prescription Required
