What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Combigan (Brimonidine / Timolol)


Combigan (Brimonidine / Timolol)

Prescription Required

0.2%-0.5% 5ml

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

Generic Equivalent - Combigan (Brimonidine / Timolol)

Prescription Required

0.2%/0.5% 5ml

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details


    Glaucoma Treatment

    Buy Combigan Eye Drop

    Combigan (Brimonidine/Timolol)

    Combigan is a combination of 2 drugs used to treat high-pressure symptoms of the eye, namely glaucoma (open-angle type) and some other eye diseases like ocular hypertension. Lowering the pressure in the eye helps prevent blindness in these conditions. Combigan eye drops are used when single-ingredient drugs are unable to treat glaucoma.

    The 2 drugs in Cambigan are brimonidine and timolol. Brimonidine is an alpha agonist. It acts by decreasing the amount of fluid formed in the eye along with improving the fluid drainage from within the eye. Timolol belongs to the group of beta blockers. It decreases the amount of fluid formed within the eye. The effect of both drugs results in lowering the intra ocular pressure and giving relief to the patient.

    Combigan eye drops are not recommended for children under 2 years of age due to increased risk of side effects.

    You can buy Combigan eye drops for glaucoma treatment from Canada Pharmacy and have it delivered to you.

    Fact Table


    Brimonidine: C11H10BrN5
    Timolol: C13H24N4O3S


    FDA approved


    Brimonidine: Topically in the eye, not systemically quantified
    Timolol: 60-80% (ocularly applied)

    Legal status

    Prescription only

    Chemical Name

    Brimonidine / Timolol

    Elimination half-life

    Brimonidine: 2-3 hours
    Timolol: 4 hours

    Dosage (Strength)

    Brimonidine 0.2% / Timolol 0.5%, Ophthalmic solution

    Pregnancy advice

    Category C (Risk not ruled out)



    Protein binding

    Brimonidine: 29%
    Timolol: 60%

    PubChem CID

    Brimonidine: 2435
    Timolol: 33624




    Brimonidine: CHEBI:3170
    Timolol: CHEBI:9599

    ATC code



    Brimonidine: DB00484
    Timolol: DB00373


    Brimonidine: D07540
    Timolol: D00603

    Routes of administration

    Topical (ocular)


    Before using Combigan eye drops, read the patient's leaflet provided by the pharmacist. The usual dose is 1 drop in the eye pouch every 12 hours or as directed by your physician. To administer the eye drop, with clean washed hands, tilt your head back. Pull down the lower eyelid and squeeze out a drop in the lower pouch. Close your eyes for 2-3 minutes, looking down, without blinking or squinting. Gently press on the inner angle of the eye to distribute the drug evenly. Repeat with the other eye.


    Active ingredients are:

    • Brimonidine 0.2%
    • Timolol 0.5%


    Before starting treatment with Combigan, if following conditions are present, consult your doctor.

    • Asthma or COPD
    • Serious heart problem like AV block
    • Congestive heart failure
    • Coronary artery disease
    • Stroke or blood clot
    • High or low blood pressure
    • Depression
    • Diabetes
    • Any allergies
    • Thyroid disorder
    • History of glaucoma

    Side Effects

    Following side effects can be associated with Combigan and may require the consultation of the doctor.

    • Slow or uneven heart rate
    • Palpitations
    • Shallow breathing, faintness
    • Severe swelling, redness or discomfort in or around the eye
    • Eye pain
    • Increased watering of the eye
    • Numbness or tingling in the hands or feet
    • Drowsiness, tiredness
    • Mild stinging or burning in eyes
    • Allergic reaction

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9597

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