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What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Compazine (Prochlorperazine)
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Strength
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Product Details
Description
Compazine is a medication commonly prescribed to treat nausea and vomiting but can also be used for migraine treatment. Compazine was initially used as an antipsychotic agent but is no longer used for this purpose.
Compazine works by blocking dopamine receptors in the brain responsible for feelings of nausea. Compazine blocks the release of hormones that cause nausea and vomiting.
Fact Table
Formula
C20H24ClN3S
License
US FDA
Bioavailability
Unknown, but presumed substantial
Legal status
Rx-only
Chemical Name
Prochlorperazine
Elimination half-life
4–8 hours
Dosage (Strength)
5mg
Pregnancy
Consult Doctor
Brands
Compazine, Stemetil
Protein binding
91–99%
PubChem CID
4917
MedlinePlus
a682116
ChEBI
8435
ATC code
N05AB04
DrugBank
DB00433
KEGG
D00493
Routes of administration
By mouth
Directions
Compazine is available in 5 mg and 10 mg tablets.
The normal dose of Compazine is 5 to 10 mg by mouth every 3 to 4 hours as needed for nausea and vomiting.
The maximum dose of Compazine in one day is 40 mg.
Take Compazine with food or water as tolerated.
Ingredients
The active ingredient in Compazine is prochlorperazine, which is also the name of the Compazine generic.
Interactions
Common drug-drug interactions with Compazine include:
- Aclidinium
- Azelastine
- Bromperidol
- Buprenorphine
- Cabergoline
- Clozapine
- Dofetilide
- Dopamine agonists
- Flunitrazepam
- Glycopyrrolate
- Iohexol
- Ipratropium
- Metoclopramide
- Opioid agonists
- Orphenadrine
- Oxybate salt products
- Potassium chloride
- Pramlintide
- Saquinavir
- Suvorexant
- Thalidomide
- Tiotropium
- Umeclidinium
- Zolpidem
Cautions
Older adults with dementia-related psychosis should not use Compazine because antipsychotic medications have been shown to increase death risk when used for this purpose.
Use caution if you have a history of heart disease.
Compazine should not be used for the long-term treatment of nausea and vomiting.
Compazine can cause dizziness or drowsiness. Do not drive until you know how it will affect you.
Side Effects
Common adverse reactions to Compazine may include:
- Agranulocytosis
- Amenorrhea
- Blurred vision
- Dizziness
- Drowsiness
- Extrapyramidal reactions
- Hypotension
- Leukopenia
- Neuroleptic malignant syndrome (NMS)
- Skin reactions
References
Compazine [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2004.
Frequently Asked Questions about Compazine
What is Compazine?
Compazine is a brand name for the medication prochlorperazine. It belongs to a class of drugs known as antipsychotics and is primarily used to treat nausea and vomiting associated with various conditions, including chemotherapy, surgery, and certain mental health disorders.
How does Compazine work?
Compazine works by blocking the action of dopamine in the brain. This helps alleviate nausea and vomiting by affecting the areas of the brain responsible for these symptoms.
What are the common uses of Compazine?
Compazine is commonly used to manage nausea and vomiting caused by chemotherapy, radiation therapy, surgery, and various gastrointestinal disorders. It can also be prescribed to manage certain mental health conditions like schizophrenia and anxiety.
Is Compazine safe for everyone?
Compazine may not be safe for everyone, and its use should be discussed with a healthcare professional. It may have contraindications or interact with other medications, and certain medical conditions may require caution when using Compazine.
What are the potential side effects of Compazine?
Common side effects of Compazine can include drowsiness, dizziness, dry mouth, constipation, and blurred vision. In some cases, it may lead to more serious side effects like muscle stiffness, tremors, or changes in mental/mood.
Can Compazine be taken with other medications?
Compazine can interact with various medications, including other antipsychotic drugs, certain antibiotics, and medications that affect the heart's rhythm. It's important to inform your healthcare provider of all the medications you are taking to avoid potential interactions.
Can Compazine be used during pregnancy or while breastfeeding?
Pregnant or breastfeeding individuals should consult their healthcare provider before using Compazine. The safety of Compazine during pregnancy and breastfeeding is not well-established, and its use should be carefully considered based on individual circumstances.
Is Compazine addictive?
Compazine is not considered addictive in the same way some other medications or substances are. However, it should be used as prescribed by a healthcare professional to avoid potential misuse.
How is Compazine typically administered?
Compazine is available in various forms, including oral tablets, suppositories, and injections. The method of administration and dosage will depend on the specific condition being treated and the healthcare provider's recommendations.
Can Compazine be used in children?
Compazine is not typically recommended for use in children without careful consideration and supervision by a healthcare provider. Pediatric dosages and safety should be discussed with a pediatrician.
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IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2691
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