A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Compazine (Prochlorperazine)
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Product Details
Description
Compazine is a medication commonly prescribed to treat nausea and vomiting but can also be used for migraine treatment. Compazine was initially used as an antipsychotic agent but is no longer used for this purpose.
Compazine works by blocking dopamine receptors in the brain responsible for feelings of nausea. Compazine blocks the release of hormones that cause nausea and vomiting.
Fact Table
Formula
C20H24ClN3S
License
US FDA
Bioavailability
Unknown, but presumed substantial
Legal status
Rx-only
Chemical Name
Prochlorperazine
Elimination half-life
4–8 hours
Dosage (Strength)
5mg
Pregnancy
Consult Doctor
Brands
Compazine, Stemetil
Protein binding
91–99%
PubChem CID
4917
MedlinePlus
a682116
ChEBI
8435
ATC code
N05AB04
DrugBank
DB00433
KEGG
D00493
Routes of administration
By mouth
Directions
Compazine is available in 5 mg and 10 mg tablets.
The normal dose of Compazine is 5 to 10 mg by mouth every 3 to 4 hours as needed for nausea and vomiting.
The maximum dose of Compazine in one day is 40 mg.
Take Compazine with food or water as tolerated.
Ingredients
The active ingredient in Compazine is prochlorperazine, which is also the name of the Compazine generic.
Interactions
Common drug-drug interactions with Compazine include:
Aclidinium
Azelastine
Bromperidol
Buprenorphine
Cabergoline
Clozapine
Dofetilide
Dopamine agonists
Flunitrazepam
Glycopyrrolate
Iohexol
Ipratropium
Metoclopramide
Opioid agonists
Orphenadrine
Oxybate salt products
Potassium chloride
Pramlintide
Saquinavir
Suvorexant
Thalidomide
Tiotropium
Umeclidinium
Zolpidem
Cautions
Older adults with dementia-related psychosis should not use Compazine because antipsychotic medications have been shown to increase death risk when used for this purpose.
Use caution if you have a history of heart disease.
Compazine should not be used for the long-term treatment of nausea and vomiting.
Compazine can cause dizziness or drowsiness. Do not drive until you know how it will affect you.
Side Effects
Common adverse reactions to Compazine may include:
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 2691
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