What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Complera (Emtricitabine / Rilpivirine / Tenofovir Disoproxil Fumarate)


Complera (Emtricitabine / Rilpivirine / Tenofovir Disoproxil Fumarate)

Prescription Required

200mg / 25mg / 300mg

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  • Product Details


    Complera is three drugs in one: two nucleoside analog HIV-1 reverse transcriptase inhibitors, emtricitabine and tenofovir disoproxil fumarate, and one non-nucleoside reverse transcriptase inhibitor, rilpivirine, for the treatment of HIV-1 infection in patients who weigh 35 kg or more. 

    Complera may not be right for everyone, so talk to your doctor about which treatment option is best for you.

    Complera is available in an oral tablet containing 200 mg of emtricitabine, 25 mg of rilpivirine, and 300 mg of tenofovir disoproxil fumarate.


    Carefully read and follow the instructions that come with your prescription. Take Complera as your doctor has prescribed. Any questions or concerns should be addressed with your doctor or pharmacist.

    The recommended dose in adult and pediatric patients who weigh 35 kg or more is one tablet by mouth once daily. Take with food. 

    Fact Table


    Emtricitabine: C8H10FN3O3S Rilpivirine: C22H18N6O Tenofovir Disoproxil Fumarate: C19H30N5O10P


    Approved by the FDA and EMA for the treatment of HIV


    Emtricitabine: 93% Rilpivirine: 33% (under fasting conditions) Tenofovir Disoproxil Fumarate: 25% (boosted to 39% with a high-fat meal)

    Legal status


    Chemical Name

    Emtricitabine / Rilpivirine / Tenofovir Disoproxil Fumarate

    Elimination half-life

    Emtricitabine: 10 hours Rilpivirine: 45 hours Tenofovir Disoproxil Fumarate: 14-17 hours

    Dosage (Strength)

    200mg / 25mg / 300mg


    Consult doctor



    Protein binding

    Emtricitabine: 4% Rilpivirine: 99.7% Tenofovir Disoproxil Fumarate: 0.7% to 7.2%

    PubChem CID

    Emtricitabine: 60877 Rilpivirine: 6451161 Tenofovir Disoproxil Fumarate: 5481350




    Emtricitabine: 31552 Rilpivirine: 59527 Tenofovir Disoproxil Fumarate: 63625

    ATC code



    Emtricitabine: DB00879 Rilpivirine: DB08864 Tenofovir Disoproxil Fumarate: DB00300


    Emtricitabine: D01199 Rilpivirine: D09727 Tenofovir Disoproxil Fumarate: D01982

    Routes of administration



    Two nucleoside analog HIV-1 reverse transcriptase inhibitors, emtricitabine and tenofovir disoproxil fumarate, and one non-nucleoside reverse transcriptase inhibitor, rilpivirine, are contained in each Complera tablet.


    Complera should not be given with medications that can decrease its response to HIV-1 or cause the virus to be resistant to Complera. These medications include carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine, dexamethasone, St. John's wort, dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole. Ask your doctor if you are unsure whether or not you take any of these medications.


    Complera contains a FDA Boxed Warning regarding severe worsening of hepatitis B virus (HBV) in patients with HIV-1 and HBV who stopped taking medications containing emtricitabine and/or tenofovir disoproxil fumarate.

    • Before you start treatment with Complera, you should discuss the following with your doctor:
      • About all the medications you take, including prescription and over-the-counter
      • Your allergies
      • Your medical history and health problems
      • Your pregnancy or breastfeeding status
    • Allergic reactions, including fever, rash, blisters, and swelling, can occur with the use of Complera.
    • Complera can cause liver problems in patients. The risk is greater in patients who have hepatitis B or C or elevated liver enzymes.
    • Complera can cause depression and other mood changes.
    • Kidney problems can occur with the use of Complera and should not be given to patients with moderate or severe kidney problems. 
    • Bone mineral density can be decreased by Complera. 
    • Taking Complera with medications that can prolong the QTc interval can increase the risk of Torsade de Pointes, a serious abnormal heart rhythm.
    • Lactic acidosis and liver enlargement with extra fat in the liver that can be fatal may occur with the use of Complera.
    • Immune system problems can occur with the use of Complera.

    Side Effects

    Complera side effects include depression, headache, trouble sleeping, abnormal dreams, dizziness, nausea, and rash. However, these are not all the side effects that can occur.

    Call your doctor immediately if you have side effects that are concerning or won't go away.


    1. Complera (emtricitabine, rilpivirine, tenofovir disoproxil fumarate) tablets, for oral use. Foster City, CA: Gilead Sciences, Inc.; 2019.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 12932

  • Product Reviews


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