What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Contrave (Bupropion/Naltrexone)

Also Known as Mysimba


Contrave (Bupropion/Naltrexone)

Prescription Required

8mg / 90mg

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  • Product Details


    Contrave is used with diet and exercise to help manage weight in adults who are:

    • Obese or
    • Overweight and have a weight-related comorbidity such as diabetes, high blood pressure, or high cholesterol

    Contrave is a combination of two medications: naltrexone, an opioid antagonist, and bupropion, an antidepressant. Contrave is available in an extended-release oral tablet containing 8 mg of naltrexone hydrochloride (HCl) and 90 mg of bupropion HCl.


    Take Contrave exactly as your doctor has prescribed. Your dose may be increased every week for four weeks, up to a maximum of 2 tablets by mouth twice daily.

    If you have any questions or concerns about your prescription, talk to your doctor or pharmacist.


    Each extended-release tablet contains 8 mg of naltrexone hydrochloride (HCl) and 90 mg of bupropion HCl. The inactive ingredients include microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, L-cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, lactose monohydrate, colloidal silicon dioxide, Opadry II Blue, and FD and C Blue #2 aluminum lake.


    Do not take Contrave medication if you:

    • Have uncontrolled high blood pressure
    • Have seizure disorders
    • Have anorexia nervosa or bulimia
    • Are undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic medications
    • Are taking other medications that contain bupropion
    • Are taking opioids chronically
    • Are taking monoamine oxidase inhibitors (MAOIs)
    • Have an allergy to naltrexone, bupropion, or any of the other ingredients in Contrave

    Fact Table







    Legal status

    RX Only

    Chemical Name


    Elimination half-life

    5 hours

    Dosage (Strength)

    8mg or 90mg (112 tablets)


    Consult a doctor



    Protein binding

    Naltrexone 21%, Bupropion 84%

    PubChem CID






    ATC code






    Routes of administration

    By mouth


    • Contrave has a FDA Boxed Warning regarding an increased risk of suicidal thoughts or behavior. Patients who are taking Contrave should be monitored for suicidal thoughts or behaviors.
    • Before you start treatment with Contrave, it's important that you tell your doctor about:
      • All the medications you take
      • Your allergies
      • Your health history and current health problems
      • Your pregnancy or breastfeeding status
    • While quitting smoking, neuropsychiatric adverse events such as mood changes, psychosis, hallucinations, paranoia, agitation, and anxiety can occur in patients taking Contrave. If any of these effects occur, patients should contact their doctor right away.
    • The risk of seizures may be reduced with adherence to the dosing schedule and avoiding a high-fat meal when taking Contrave.
    • Heart rate and blood pressure can increase with the use of Contrave.
    • Liver damage can occur with the use of Contrave.
    • Glaucoma can occur with the use of Contrave.
    • Low blood sugar may occur with the use of antidiabetic medications and weight loss that can occur with Contrave.

    Side Effects

    The most common Contrave side effects include nausea, constipation, headache, vomiting, dizziness, sleep problems, dry mouth, and diarrhea. However, these are not all the side effects that can occur. Call your doctor right away if you develop bothersome or persistent side effects.


    Contrave. Brentwood, TN: Currax™ Pharmaceuticals, LLC; 2021.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13241

  • Product Reviews


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