What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Credelio Plus (Lotilaner+Milbemycin Oxime)


Credelio Plus (Lotilaner+Milbemycin Oxime)

Prescription Required

56.25 / 2.11mg Dogs
112.5 / 4.11mg Dogs
225 / 8.44mg Dogs
450 / 16.88mg Dogs
900 / 33.75mg Dogs

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  • Product Details


    Credelio Plus (lotilaner and milbemycin oxime) is a medication prescribed by a licensed veterinarian to treat ticks and fleas PLUS worms (gastrointestinal and lung) PLUS prevent heartworm disease in dogs.


    Credelio Plus is available in five different chewable tablet strengths. The dose depends on your dog's weight. Discuss appropriate dosing and scheduling with your vet. Follow your vet's instructions on how to properly administer Credelio Plus to your dog. 

    Credelio Plus should be given with or after your dog's meal. 

    Credelio Plus should not be used in humans. Keep the medication away from children and other pets.


    Lotilaner and milbemycin oxime are the active ingredients contained in Credelio Plus.


    • Before Credelio Plus is administered to your dog, tell your vet about your dog's:
      • Medications
      • Allergies
      • Medical history and health problems
      • Pregnancy or nursing status
    • Lotilaner, an isoxazoline, has been associated with neurological adverse reactions such as tremors, balance and coordination problems, and seizures. Seizures can occur in dogs that don't have a history of seizures. Caution should be used, especially in dogs with a history of seizures or neurological problems.

    Side Effects

    Credelio Plus can cause weight loss, diarrhea, vomiting, muscle tremors, lack of energy, itching, and behavioral changes. Call your vet right away if your dog develops side effects that worry you or won't go away. 


    1. Credelio Plus. European Medicines Agency; 2021.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13569

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