What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate)


Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate)

Prescription Required

100mg / 300mg / 300mg

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  • Product Details


    Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate) is a three-drug combination. It's indication is for the treatment of HIV-1 infection in adults and pediatric patients who weigh 77 pounds (35 kilograms) or more:

    • With no previous treatment for HIV-1 OR
    • To replace their current HIV-1 medications if they meet certain requirements per their doctor

    Fact Table




    US DailyMed


    64%, 86%, 25%

    Legal status


    Chemical Name

    Doravirine, lamivudine, and tenofovir disoproxil fumarate

    Elimination half-life

    15 hrs

    Dosage (Strength)



    Consult Doctor



    Protein binding

    Around 75%

    PubChem CID






    ATC code






    Routes of administration

    By mouth


    Delstrigo is available as a tablet (100 mg doravirine/300 mg lamivudine/300 mg tenofovir disoproxil fumarate). 

    The recommended dose is one tablet by mouth once daily with or without food.

    Your dose may be adjusted if you take rifabutin.


    The active ingredients in Delstrigo are: doravine (a non-nucleoside reverse transcriptase inhibitor), lamivudine (a nucleoside analogue reverse transcriptase inhibitor), and tenofovir disoproxil fumarate (a nucleoside analogue reverse transcriptase inhibitor). 


    Do not take Delstrigo if you are allergic to doravine, lamivudine, tenofovir disoproxil fumarate, or any of the other ingredients in Delstrigo.

    Avoid taking Delstrigo if you take:

    • Carbamazepine
    • Oxcarbazepine
    • Phenobarbital
    • Phenytoin
    • Enzalutamide
    • Rifampin
    • Rifapentine
    • Mitotane
    • St. John's wort



    See full prescribing information for complete boxed warning.

    Severe acute exacerbations of hepatitis B (HBV) have been reported in patients coinfected with HIV-1 and HBV who have discontinued lamivudine or tenofovir disoproxil fumarate (TDF), two of the components of DELSTRIGO. Closely monitor hepatic function in these patients. If appropriate, initiation of anti-hepatitis B therapy may be warranted.

    • Before you start taking Delstrigo, tell your doctor:
      • About any medications you take, including prescription, over-the-counter, vitamins, and herbal supplements.
      • About all your health conditions, including hepatitis B infection, kidney problems, or bone problems
      • If you are pregnant or plan to become pregnant
      • If you are breastfeeding or plan to breastfeed
    • Delstrigo can cause immune system changes such as fighting off infections that have been dormant in your body. Contact your doctor right away if you develop new symptoms while being treated with Delstrigo. 

    Side Effects

    Delstrigo can cause side effects. The most common include unusual dreams, dizziness, and nausea. 

    Tell your doctor if you develop side effects that bother you or won't go away.


    1. Delstrigo Prescribing Information. Whitehouse Station, NJ: Merck & Co., Inc.; 2022.
    2. Delstrigo Patient Information. Whitehouse Station, NJ: Merck & Co., Inc.; 2022.

    Frequently Asked Questions about Delstrigo (Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate)

    What is Delstrigo?

    Delstrigo is a complete, one-pill HIV medication for adults. It combines three antiretroviral drugs: doravirine, lamivudine, and tenofovir disoproxil fumarate, to help control the HIV-1 virus.

    Who can take Delstrigo?

    Delstrigo is primarily for adults with HIV-1 who haven't taken HIV medications before or who can safely switch from their current regimen under their doctor's guidance.

    How is Delstrigo taken?

    Take one Delstrigo tablet with or without food, once daily. Don't split, crush, or chew the tablets.

    How does Delstrigo work?

    The three drugs in Delstrigo target different stages of the HIV virus lifecycle, preventing it from multiplying and ultimately helping lower the viral load.

    How effective is Delstrigo?

    In studies, Delstrigo effectively suppressed the HIV virus in most patients, achieving undetectable viral loads.

    Are there any side effects?

    Common side effects include headache, nausea, fatigue, and diarrhea. More serious side effects are rare but possible. Consult your doctor if you experience any bothersome side effects.

    Can I take Delstrigo with other medications?

    Tell your doctor about all your medications, including supplements and over-the-counter drugs, as some may interact with Delstrigo.

    Does Delstrigo cure HIV?

    No, Delstrigo doesn't cure HIV, but it can effectively manage the virus and help people with HIV live long and healthy lives.

    Is Delstrigo available over-the-counter?

    No, Delstrigo is a prescription medication only available through your healthcare provider.

    What should I do if I miss a dose?

    Take the missed dose as soon as possible, but skip it if it's near time for your next dose. Don't take two doses at once.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13598

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