What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate)

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Brand

Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate)

Prescription Required

Strength
Qty
100mg / 300mg / 300mg

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  • Product Details

    Description

    Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate) is a three-drug combination. It's indication is for the treatment of HIV-1 infection in adults and pediatric patients who weigh 77 pounds (35 kilograms) or more:

    • With no previous treatment for HIV-1 OR
    • To replace their current HIV-1 medications if they meet certain requirements per their doctor

    Fact Table

    Formula

    C17H11ClF3N5O3

    License

    US DailyMed

    Bioavailability

    64%, 86%, 25%

    Legal status

    Rx-Only

    Chemical Name

    Doravirine, lamivudine, and tenofovir disoproxil fumarate

    Elimination half-life

    15 hrs

    Dosage (Strength)

    100mg/300mg/300mg

    Pregnancy

    Consult Doctor

    Brands

    Delstrigo

    Protein binding

    Around 75%

    PubChem CID

    -

    MedlinePlus

    a618049

    ChEBI

    -

    ATC code

    J05AR24

    DrugBank

    -

    KEGG

    D11396

    Routes of administration

    By mouth

    Directions

    Delstrigo is available as a tablet (100 mg doravirine/300 mg lamivudine/300 mg tenofovir disoproxil fumarate). 

    The recommended dose is one tablet by mouth once daily with or without food.

    Your dose may be adjusted if you take rifabutin.

    Ingredients

    The active ingredients in Delstrigo are: doravine (a non-nucleoside reverse transcriptase inhibitor), lamivudine (a nucleoside analogue reverse transcriptase inhibitor), and tenofovir disoproxil fumarate (a nucleoside analogue reverse transcriptase inhibitor). 

    Contraindications

    Do not take Delstrigo if you are allergic to doravine, lamivudine, tenofovir disoproxil fumarate, or any of the other ingredients in Delstrigo.

    Avoid taking Delstrigo if you take:

    • Carbamazepine
    • Oxcarbazepine
    • Phenobarbital
    • Phenytoin
    • Enzalutamide
    • Rifampin
    • Rifapentine
    • Mitotane
    • St. John's wort

    Cautions

    WARNING: POSTTREATMENT ACUTE EXACERBATION OF HEPATITIS B

    See full prescribing information for complete boxed warning.

    Severe acute exacerbations of hepatitis B (HBV) have been reported in patients coinfected with HIV-1 and HBV who have discontinued lamivudine or tenofovir disoproxil fumarate (TDF), two of the components of DELSTRIGO. Closely monitor hepatic function in these patients. If appropriate, initiation of anti-hepatitis B therapy may be warranted.

    • Before you start taking Delstrigo, tell your doctor:
      • About any medications you take, including prescription, over-the-counter, vitamins, and herbal supplements.
      • About all your health conditions, including hepatitis B infection, kidney problems, or bone problems
      • If you are pregnant or plan to become pregnant
      • If you are breastfeeding or plan to breastfeed
    • Delstrigo can cause immune system changes such as fighting off infections that have been dormant in your body. Contact your doctor right away if you develop new symptoms while being treated with Delstrigo. 

    Side Effects

    Delstrigo can cause side effects. The most common include unusual dreams, dizziness, and nausea. 

    Tell your doctor if you develop side effects that bother you or won't go away.

    References:

    1. Delstrigo Prescribing Information. Whitehouse Station, NJ: Merck & Co., Inc.; 2022.
    2. Delstrigo Patient Information. Whitehouse Station, NJ: Merck & Co., Inc.; 2022.


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13598

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