What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Deplin (Levomefolate Calcium)


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Generic Equivalent - Deplin (Levomefolate Calcium)

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  • Product Details


    Deplin is a prescription medical food that is used to increase folate levels in the treatment of Major Depressive Disorder (MDD) or hyperhomocysteinemia in patients with schizophrenia. Deplin is the brand name for folate, which is usually made in the body but can be deficient in some conditions.

    Folate is responsible for helping to create DNA, RNA, and other essential molecules in the body. Deplin replaces folate that cannot be absorbed from the diet alone.

    Fact Table




    US FDA



    Legal status

    US: OTC

    Chemical Name

    Levomefolate Calcium

    Elimination half-life

    3 hour

    Dosage (Strength)

    7.5mg, 15mg


    Consult Doctor



    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    For depression, the usual dose is one Deplin 15 mg capsule or one to two 7.5 mg capsules once daily in addition to standard antidepressant therapy.

    For schizophrenia, the dosage is also 7.5-15 mg by mouth once daily.

    Only use Deplin under the supervision of a physician or other healthcare professional. Deplin is a medical food that should only be used by people who cannot obtain the nutrient with normal diet modifications.

    Store Deplin at room temperature, protected from heat, light, and moisture.


    The active ingredient in Deplin generic is L-methylfolate.


    Deplin can interact with many other substances, including:

    • Alcohol
    • Capecitabine
    • Carbamazepine
    • Cholestyramine
    • Cigarettes
    • Colestipol
    • Cycloserine
    • Ibuprofen
    • Indomethacin
    • Isotretinoin
    • Lamotrigine
    • Methotrexate
    • Methylprednisolone
    • Naproxen
    • Oral contraceptives
    • Pancreatic enzymes
    • Pentamidine
    • Phenobarbital
    • Phenytoin
    • Primidone
    • Pyrimethamine
    • Sulfasalazine
    • Sulindac
    • Triamterene
    • Trimethoprim
    • Valproic acid


    Deplin is not interchangeable with folic acid supplementation.

    Do not take this medication if you have a known hypersensitivity to Deplin or any of the inactive ingredients. 

    Side Effects

    No significant Deplin side effects have been reported with Deplin except for allergic (hypersensitive reactions).


    Deplin. Covington, LA: Pamlab; 2009.

    Frequently Asked Questions about Deplin

    What is Deplin?

    Deplin is a prescription medication that contains a form of folate, a type of B-vitamin. It is used as an adjunctive treatment for certain types of depression and mood disorders.

    How does Deplin work?

    Deplin works by providing the body with L-methylfolate, the active form of folate. Some people with depression have a deficiency in L-methylfolate, and Deplin helps to correct this deficiency. It may enhance the effectiveness of other antidepressant medications.

    Who can benefit from Deplin?

    Deplin is typically prescribed for individuals who have been diagnosed with major depressive disorder (MDD) or other mood disorders, especially when there is evidence of folate deficiency. It is often used in conjunction with other antidepressant medications.

    Is Deplin a standalone treatment for depression?

    No, Deplin is not meant to be used as a standalone treatment for depression. It is intended to be used as an adjunctive therapy alongside traditional antidepressant medications, not as a replacement.

    How is Deplin taken?

    Deplin is usually taken once daily as a dietary supplement. The dosage may vary depending on your specific condition, so follow your healthcare provider's instructions carefully.

    Are there any side effects associated with Deplin?

    Deplin is generally well-tolerated. However, some people may experience mild side effects, such as nausea, upset stomach, or headache. If you experience any unusual or severe side effects, consult your healthcare provider.

    Can Deplin be taken with other medications?

    Deplin is often prescribed alongside other antidepressant medications. However, it's essential to inform your healthcare provider about all the medications and supplements you are taking to ensure there are no potential interactions.

    How long does it take to see results with Deplin?

    The time it takes to see improvements in your mood can vary from person to person. Some individuals may notice positive changes within a few weeks, while others may take longer. Be patient and continue taking Deplin as prescribed.

    Can I take Deplin without a prescription?

    No, Deplin is a prescription medication, and you should only take it under the guidance of a qualified healthcare provider who has evaluated your specific condition and determined it to be an appropriate treatment option.

    Are there any dietary restrictions when taking Deplin?

    While there are no specific dietary restrictions associated with Deplin, maintaining a balanced diet and a healthy lifestyle can complement the treatment's effectiveness.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10252

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